Anticancer α-, γ-, and δ-carboline derivatives: structures, mechanisms of action, and SARs
Carboline consists of a pyridine ring fused with an indole skeleton, and it serves as a potential drug scaffold. Depending on the relative position of the pyridine N to the indole N, carbolines can be categorized into α-, β-, γ-, and δ-subfamilies. They have diverse pharmacological activities, such...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | European Journal of Medicinal Chemistry Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772417424000931 |
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| author | Jingliang Cui Wanru Gao Ziwei Liu Shuang Cao Sihui Long |
| author_facet | Jingliang Cui Wanru Gao Ziwei Liu Shuang Cao Sihui Long |
| author_sort | Jingliang Cui |
| collection | DOAJ |
| description | Carboline consists of a pyridine ring fused with an indole skeleton, and it serves as a potential drug scaffold. Depending on the relative position of the pyridine N to the indole N, carbolines can be categorized into α-, β-, γ-, and δ-subfamilies. They have diverse pharmacological activities, such as anticancer, antimalaria, antibacterial, antifungal, anti-Alzheimer's disease, etc. Among them, β-carbolines are the most widely studied and are also well reviewed. Herein, we review the anticancer activity of α-, γ-, and δ-carboline natural products and their synthetic derivatives, as they provide new inroads for cancer therapy. Particularly, we highlight the new derivatives of α-, γ-, and δ-carboline with anticancer activity, and their anticancer mechanisms, as well as structure-activity relationship. Meanwhile, we propose strategies for the development of new α-, γ-, and δ-carboline derivatives for cancer therapy. |
| format | Article |
| id | doaj-art-2dd5d27238e44009b1187db24cf36017 |
| institution | OA Journals |
| issn | 2772-4174 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Medicinal Chemistry Reports |
| spelling | doaj-art-2dd5d27238e44009b1187db24cf360172025-08-20T02:30:42ZengElsevierEuropean Journal of Medicinal Chemistry Reports2772-41742024-12-011210022110.1016/j.ejmcr.2024.100221Anticancer α-, γ-, and δ-carboline derivatives: structures, mechanisms of action, and SARsJingliang Cui0Wanru Gao1Ziwei Liu2Shuang Cao3Sihui Long4Key Laboratory for Green Chemical Process of Ministry of Education, Hubei Key Laboratory of Novel Reactor and Green Chemical Technology, Hubei Engineering Research Center for Advanced Fine Chemicals, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, 206 1st Rd Optics Valley, East Lake New Technology Development District, Wuhan, Hubei, 430205, ChinaKey Laboratory for Green Chemical Process of Ministry of Education, Hubei Key Laboratory of Novel Reactor and Green Chemical Technology, Hubei Engineering Research Center for Advanced Fine Chemicals, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, 206 1st Rd Optics Valley, East Lake New Technology Development District, Wuhan, Hubei, 430205, ChinaKey Laboratory for Green Chemical Process of Ministry of Education, Hubei Key Laboratory of Novel Reactor and Green Chemical Technology, Hubei Engineering Research Center for Advanced Fine Chemicals, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, 206 1st Rd Optics Valley, East Lake New Technology Development District, Wuhan, Hubei, 430205, ChinaCorresponding author.; Key Laboratory for Green Chemical Process of Ministry of Education, Hubei Key Laboratory of Novel Reactor and Green Chemical Technology, Hubei Engineering Research Center for Advanced Fine Chemicals, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, 206 1st Rd Optics Valley, East Lake New Technology Development District, Wuhan, Hubei, 430205, ChinaCorresponding author.; Key Laboratory for Green Chemical Process of Ministry of Education, Hubei Key Laboratory of Novel Reactor and Green Chemical Technology, Hubei Engineering Research Center for Advanced Fine Chemicals, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, 206 1st Rd Optics Valley, East Lake New Technology Development District, Wuhan, Hubei, 430205, ChinaCarboline consists of a pyridine ring fused with an indole skeleton, and it serves as a potential drug scaffold. Depending on the relative position of the pyridine N to the indole N, carbolines can be categorized into α-, β-, γ-, and δ-subfamilies. They have diverse pharmacological activities, such as anticancer, antimalaria, antibacterial, antifungal, anti-Alzheimer's disease, etc. Among them, β-carbolines are the most widely studied and are also well reviewed. Herein, we review the anticancer activity of α-, γ-, and δ-carboline natural products and their synthetic derivatives, as they provide new inroads for cancer therapy. Particularly, we highlight the new derivatives of α-, γ-, and δ-carboline with anticancer activity, and their anticancer mechanisms, as well as structure-activity relationship. Meanwhile, we propose strategies for the development of new α-, γ-, and δ-carboline derivatives for cancer therapy.http://www.sciencedirect.com/science/article/pii/S2772417424000931α-, γ-, δ-carbolineDerivativesAnticancer activitySARMechanismStrategies |
| spellingShingle | Jingliang Cui Wanru Gao Ziwei Liu Shuang Cao Sihui Long Anticancer α-, γ-, and δ-carboline derivatives: structures, mechanisms of action, and SARs European Journal of Medicinal Chemistry Reports α-, γ-, δ-carboline Derivatives Anticancer activity SAR Mechanism Strategies |
| title | Anticancer α-, γ-, and δ-carboline derivatives: structures, mechanisms of action, and SARs |
| title_full | Anticancer α-, γ-, and δ-carboline derivatives: structures, mechanisms of action, and SARs |
| title_fullStr | Anticancer α-, γ-, and δ-carboline derivatives: structures, mechanisms of action, and SARs |
| title_full_unstemmed | Anticancer α-, γ-, and δ-carboline derivatives: structures, mechanisms of action, and SARs |
| title_short | Anticancer α-, γ-, and δ-carboline derivatives: structures, mechanisms of action, and SARs |
| title_sort | anticancer α γ and δ carboline derivatives structures mechanisms of action and sars |
| topic | α-, γ-, δ-carboline Derivatives Anticancer activity SAR Mechanism Strategies |
| url | http://www.sciencedirect.com/science/article/pii/S2772417424000931 |
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