Tumor Microenvironment Triggered In Situ Coagulation of Supramolecularly Engineered Platelets for Precise Tumor Embolization
Abstract Although embolization therapy has demonstrated success in impeding tumor growth, concerns persist regarding potential tumor recurrence and inadvertent embolization of non‐target tissues. In this study, drawing inspiration from the natural targeting and coagulation process of platelets in in...
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Wiley
2025-07-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202414879 |
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| author | Junyan Li Ziyi Wang Ruifeng Luo Xingping Quan Hong U Fong Qian Cheng Jianwen Wei Leo Wang Yonghua Zhao Ruibing Wang |
| author_facet | Junyan Li Ziyi Wang Ruifeng Luo Xingping Quan Hong U Fong Qian Cheng Jianwen Wei Leo Wang Yonghua Zhao Ruibing Wang |
| author_sort | Junyan Li |
| collection | DOAJ |
| description | Abstract Although embolization therapy has demonstrated success in impeding tumor growth, concerns persist regarding potential tumor recurrence and inadvertent embolization of non‐target tissues. In this study, drawing inspiration from the natural targeting and coagulation process of platelets in injured blood vessels, platelets are engineered by integrating acid‐sensitive, morphology‐transformable nanoparticles onto their surface through supramolecular conjugation (PLT‐NP). The nanoparticles are constructed through the self‐assembly of a β‐amyloid derived peptide (FFVLK) terminally functionalized with Fmoc, hexahistidine (His6), and a polyethylene glycol (PEG)‐functionalized cyclodextrin (CD). The supramolecularly engineered platelets actively accumulate in the tumor tissue upon inducing a tumor blood vessel injury through tumor resection. In response to the local acidic microenvironment, the nanoparticles undergo a morphological transformation into nanofibers via spontaneous assembly of FFLVK into fibril structures through hydrogen bonding and β‐sheet interactions, to artificially enhance the coagulation and aggregation of platelets, causing occlusion of tumor blood vessels. The supramolecularly engineered platelets efficiently embolize tumor blood vessels in a specific manner, effectively suppressing tumor growth, metastasis, and recurrence, thus offering a promising paradigm for combating cancer. |
| format | Article |
| id | doaj-art-2dce9640e9dd4925aac29304f5a764ff |
| institution | DOAJ |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-2dce9640e9dd4925aac29304f5a764ff2025-08-20T03:04:57ZengWileyAdvanced Science2198-38442025-07-011226n/an/a10.1002/advs.202414879Tumor Microenvironment Triggered In Situ Coagulation of Supramolecularly Engineered Platelets for Precise Tumor EmbolizationJunyan Li0Ziyi Wang1Ruifeng Luo2Xingping Quan3Hong U Fong4Qian Cheng5Jianwen Wei6Leo Wang7Yonghua Zhao8Ruibing Wang9State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau Taipa Macao SAR 999078 ChinaState Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau Taipa Macao SAR 999078 ChinaState Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau Taipa Macao SAR 999078 ChinaState Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau Taipa Macao SAR 999078 ChinaState Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau Taipa Macao SAR 999078 ChinaState Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau Taipa Macao SAR 999078 ChinaState Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau Taipa Macao SAR 999078 ChinaState Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau Taipa Macao SAR 999078 ChinaState Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau Taipa Macao SAR 999078 ChinaState Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau Taipa Macao SAR 999078 ChinaAbstract Although embolization therapy has demonstrated success in impeding tumor growth, concerns persist regarding potential tumor recurrence and inadvertent embolization of non‐target tissues. In this study, drawing inspiration from the natural targeting and coagulation process of platelets in injured blood vessels, platelets are engineered by integrating acid‐sensitive, morphology‐transformable nanoparticles onto their surface through supramolecular conjugation (PLT‐NP). The nanoparticles are constructed through the self‐assembly of a β‐amyloid derived peptide (FFVLK) terminally functionalized with Fmoc, hexahistidine (His6), and a polyethylene glycol (PEG)‐functionalized cyclodextrin (CD). The supramolecularly engineered platelets actively accumulate in the tumor tissue upon inducing a tumor blood vessel injury through tumor resection. In response to the local acidic microenvironment, the nanoparticles undergo a morphological transformation into nanofibers via spontaneous assembly of FFLVK into fibril structures through hydrogen bonding and β‐sheet interactions, to artificially enhance the coagulation and aggregation of platelets, causing occlusion of tumor blood vessels. The supramolecularly engineered platelets efficiently embolize tumor blood vessels in a specific manner, effectively suppressing tumor growth, metastasis, and recurrence, thus offering a promising paradigm for combating cancer.https://doi.org/10.1002/advs.202414879cell carriersembolization therapymorphology transformationplateletssupramolecular |
| spellingShingle | Junyan Li Ziyi Wang Ruifeng Luo Xingping Quan Hong U Fong Qian Cheng Jianwen Wei Leo Wang Yonghua Zhao Ruibing Wang Tumor Microenvironment Triggered In Situ Coagulation of Supramolecularly Engineered Platelets for Precise Tumor Embolization Advanced Science cell carriers embolization therapy morphology transformation platelets supramolecular |
| title | Tumor Microenvironment Triggered In Situ Coagulation of Supramolecularly Engineered Platelets for Precise Tumor Embolization |
| title_full | Tumor Microenvironment Triggered In Situ Coagulation of Supramolecularly Engineered Platelets for Precise Tumor Embolization |
| title_fullStr | Tumor Microenvironment Triggered In Situ Coagulation of Supramolecularly Engineered Platelets for Precise Tumor Embolization |
| title_full_unstemmed | Tumor Microenvironment Triggered In Situ Coagulation of Supramolecularly Engineered Platelets for Precise Tumor Embolization |
| title_short | Tumor Microenvironment Triggered In Situ Coagulation of Supramolecularly Engineered Platelets for Precise Tumor Embolization |
| title_sort | tumor microenvironment triggered in situ coagulation of supramolecularly engineered platelets for precise tumor embolization |
| topic | cell carriers embolization therapy morphology transformation platelets supramolecular |
| url | https://doi.org/10.1002/advs.202414879 |
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