Craving on the move: targeting smoking memories with a novel 3MDR–smoking cessation protocol
IntroductionImproved effectiveness and treatment adherence is needed in smoking cessation (SC) therapies. Another important challenge is to disrupt maladaptive drug-related memories. To achieve these goals, we developed a novel treatment strategy on the basis of motion-assisted memory desensitizatio...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1398027/full |
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| author | Annel P. Koomen Anne Marije Kaag Kees A. M. Jongenelen Rianne Wouters Hein J. F. van Marle Hein J. F. van Marle Hein J. F. van Marle Hein J. F. van Marle Odile A. van den Heuvel Odile A. van den Heuvel Odile A. van den Heuvel Ysbrand D. van der Werf Ysbrand D. van der Werf Taco J. De Vries Taco J. De Vries |
| author_facet | Annel P. Koomen Anne Marije Kaag Kees A. M. Jongenelen Rianne Wouters Hein J. F. van Marle Hein J. F. van Marle Hein J. F. van Marle Hein J. F. van Marle Odile A. van den Heuvel Odile A. van den Heuvel Odile A. van den Heuvel Ysbrand D. van der Werf Ysbrand D. van der Werf Taco J. De Vries Taco J. De Vries |
| author_sort | Annel P. Koomen |
| collection | DOAJ |
| description | IntroductionImproved effectiveness and treatment adherence is needed in smoking cessation (SC) therapies. Another important challenge is to disrupt maladaptive drug-related memories. To achieve these goals, we developed a novel treatment strategy on the basis of motion-assisted memory desensitization and reprocessing (3MDR).MethodsIn this study, the added effect of a distractor task following memory recall during a newly designed 3-day SC version of 3MDR (3MDR-SC) protocol on reducing smoking cue–elicited craving was investigated in abstinent chronic smokers. Chronic smokers were randomly allocated to an active 3MDR-SC group (receiving 3MDR-SC with a working memory distractor task) (n = 42) or a control 3MDR-SC group (receiving 3MDR-SC with a non-distracting task) (n = 39). Smoking cue–induced craving and physiological measures were assessed at baseline (T0) and 1 day after the intervention (T4), and smoking behavior was measured at T0 and 2-week (FU1) and 3-month (FU2) follow-up.ResultsSignificant decreases in cue-induced craving from T0 to T4 and daily cigarette use from T0 to FU1 and FU2 were observed but not differ between the two experimental groups. Cue-induced changes in heart-rate variability and skin conductance, which did not differ from T0 to T4, and relapse at FU2 were also not different between groups. Dropout rate during intervention was 2.5%.ConclusionsThe 3-day 3MDR-SC intervention resulted in a reduction in cue-induced craving and smoking behavior and showed very good treatment adherence. There was no added effect of the distractor task on 3MDR-SC efficacy. Further studies, including a treatment as usual control, are needed to confirm 3MDR-SC as an effective SC therapy. |
| format | Article |
| id | doaj-art-2dca395bdeb5490fb6e2b96d6e6baa3d |
| institution | OA Journals |
| issn | 1664-0640 |
| language | English |
| publishDate | 2024-12-01 |
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| spelling | doaj-art-2dca395bdeb5490fb6e2b96d6e6baa3d2025-08-20T02:22:06ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402024-12-011510.3389/fpsyt.2024.13980271398027Craving on the move: targeting smoking memories with a novel 3MDR–smoking cessation protocolAnnel P. Koomen0Anne Marije Kaag1Kees A. M. Jongenelen2Rianne Wouters3Hein J. F. van Marle4Hein J. F. van Marle5Hein J. F. van Marle6Hein J. F. van Marle7Odile A. van den Heuvel8Odile A. van den Heuvel9Odile A. van den Heuvel10Ysbrand D. van der Werf11Ysbrand D. van der Werf12Taco J. De Vries13Taco J. De Vries14Department of Anatomy and Neurosciences, Amsterdam University Medical Center, Amsterdam, NetherlandsDepartment of Clinical Neuro and Developmental Psychology, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsDepartment of Anatomy and Neurosciences, Amsterdam University Medical Center, Amsterdam, NetherlandsDepartment of Anatomy and Neurosciences, Amsterdam University Medical Center, Amsterdam, NetherlandsDepartment of Psychiatry, Amsterdam University Medical Center, Amsterdam, NetherlandsGGZ inGeest Mental Health Care, Amsterdam, NetherlandsMood, Anxiety, Psychosis, Stress and Sleep, Amsterdam Neuroscience, Amsterdam, NetherlandsARQ National Psychotrauma Center, Diemen, NetherlandsDepartment of Anatomy and Neurosciences, Amsterdam University Medical Center, Amsterdam, NetherlandsDepartment of Psychiatry, Amsterdam University Medical Center, Amsterdam, NetherlandsCompulsivity Impulsivity and Attention, Amsterdam Neuroscience, Amsterdam, NetherlandsDepartment of Anatomy and Neurosciences, Amsterdam University Medical Center, Amsterdam, NetherlandsCompulsivity Impulsivity and Attention, Amsterdam Neuroscience, Amsterdam, NetherlandsDepartment of Anatomy and Neurosciences, Amsterdam University Medical Center, Amsterdam, NetherlandsCompulsivity Impulsivity and Attention, Amsterdam Neuroscience, Amsterdam, NetherlandsIntroductionImproved effectiveness and treatment adherence is needed in smoking cessation (SC) therapies. Another important challenge is to disrupt maladaptive drug-related memories. To achieve these goals, we developed a novel treatment strategy on the basis of motion-assisted memory desensitization and reprocessing (3MDR).MethodsIn this study, the added effect of a distractor task following memory recall during a newly designed 3-day SC version of 3MDR (3MDR-SC) protocol on reducing smoking cue–elicited craving was investigated in abstinent chronic smokers. Chronic smokers were randomly allocated to an active 3MDR-SC group (receiving 3MDR-SC with a working memory distractor task) (n = 42) or a control 3MDR-SC group (receiving 3MDR-SC with a non-distracting task) (n = 39). Smoking cue–induced craving and physiological measures were assessed at baseline (T0) and 1 day after the intervention (T4), and smoking behavior was measured at T0 and 2-week (FU1) and 3-month (FU2) follow-up.ResultsSignificant decreases in cue-induced craving from T0 to T4 and daily cigarette use from T0 to FU1 and FU2 were observed but not differ between the two experimental groups. Cue-induced changes in heart-rate variability and skin conductance, which did not differ from T0 to T4, and relapse at FU2 were also not different between groups. Dropout rate during intervention was 2.5%.ConclusionsThe 3-day 3MDR-SC intervention resulted in a reduction in cue-induced craving and smoking behavior and showed very good treatment adherence. There was no added effect of the distractor task on 3MDR-SC efficacy. Further studies, including a treatment as usual control, are needed to confirm 3MDR-SC as an effective SC therapy.https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1398027/fulltobacco use disordersmokingcravingEMDRsmoking cessationcue exposure |
| spellingShingle | Annel P. Koomen Anne Marije Kaag Kees A. M. Jongenelen Rianne Wouters Hein J. F. van Marle Hein J. F. van Marle Hein J. F. van Marle Hein J. F. van Marle Odile A. van den Heuvel Odile A. van den Heuvel Odile A. van den Heuvel Ysbrand D. van der Werf Ysbrand D. van der Werf Taco J. De Vries Taco J. De Vries Craving on the move: targeting smoking memories with a novel 3MDR–smoking cessation protocol Frontiers in Psychiatry tobacco use disorder smoking craving EMDR smoking cessation cue exposure |
| title | Craving on the move: targeting smoking memories with a novel 3MDR–smoking cessation protocol |
| title_full | Craving on the move: targeting smoking memories with a novel 3MDR–smoking cessation protocol |
| title_fullStr | Craving on the move: targeting smoking memories with a novel 3MDR–smoking cessation protocol |
| title_full_unstemmed | Craving on the move: targeting smoking memories with a novel 3MDR–smoking cessation protocol |
| title_short | Craving on the move: targeting smoking memories with a novel 3MDR–smoking cessation protocol |
| title_sort | craving on the move targeting smoking memories with a novel 3mdr smoking cessation protocol |
| topic | tobacco use disorder smoking craving EMDR smoking cessation cue exposure |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1398027/full |
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