Combination immunotherapy targeting LAG-3, PD-1 and STING suppresses hepatocellular carcinoma as monitored by LAG-3 targeted PET imaging

Combination immunotherapy targeting LAG-3, PD-1 and STING suppresses hepatocellular carcinoma as monitored by LAG-3 targeted PET imaging

Abstract Background The low response rate of anti-PD-1 monoclonal antibodies (mAbs) in hepatocellular carcinoma (HCC) requires the development of combination immunotherapy strategies to improve their efficacy. This study aimed to use LAG-3-targeted PET imaging to monitor the efficacy of anti-PD-1 mA...

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Bibliographic Details
Main Authors: Zhen Quan, Yu Gao, Bo Sun, Yiwan Guo, Ziwei Jin, Na Hao, Dawei Jiang, Chuansheng Zheng, Xin Li, Quan Chen
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Biomarker Research
Subjects:
Programmed cell death protein 1 (PD-1)
Stimulator of interferon genes (STING)
Lymphocyte activation gene 3 (LAG-3)
PET imaging
Combination immunotherapy
Online Access:https://doi.org/10.1186/s40364-025-00820-z
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