Seroprevalence and Seroconversion of Dengue and Implications for Clinical Diagnosis in Amazonian Children
This study aimed to evaluate the prevalence of serum IgG dengue in children in an Amazonian population, to assess the seroconversion rate in 12 months, and to estimate how many seropositive children had a prior clinical diagnosis of dengue. We conducted a population-based study between 2010 and 2011...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2014/703875 |
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| author | Antonio Camargo Martins Thasciany Moraes Pereira Humberto Oliart-Guzmán Breno Matos Delfino Saulo Augusto Silva Mantovani Athos Muniz Braña Fernando Luiz Cunha Castelo Branco José Alcântara Filgueira Júnior Ana Paula Santos Alanderson Alves Ramalho Andréia Silva Guimarães Thiago Santos de Araújo Cristieli Sérgio de Menezes Oliveira Benedito Antônio Lopes da Fonseca Mônica da Silva-Nunes |
| author_facet | Antonio Camargo Martins Thasciany Moraes Pereira Humberto Oliart-Guzmán Breno Matos Delfino Saulo Augusto Silva Mantovani Athos Muniz Braña Fernando Luiz Cunha Castelo Branco José Alcântara Filgueira Júnior Ana Paula Santos Alanderson Alves Ramalho Andréia Silva Guimarães Thiago Santos de Araújo Cristieli Sérgio de Menezes Oliveira Benedito Antônio Lopes da Fonseca Mônica da Silva-Nunes |
| author_sort | Antonio Camargo Martins |
| collection | DOAJ |
| description | This study aimed to evaluate the prevalence of serum IgG dengue in children in an Amazonian population, to assess the seroconversion rate in 12 months, and to estimate how many seropositive children had a prior clinical diagnosis of dengue. We conducted a population-based study between 2010 and 2011, with children aged 6 months to 12 years that were living in the urban area of a small town in the Brazilian Amazon. The prevalence of IgG antibodies against dengue antigens was determined by indirect ELISA technique, and seronegative children were reexamined after 12 months to determine seroconversion rates. Results showed seroprevalence of IgG antibodies against dengue type of 2.9%, with no significant association between age, race, and sex. In seropositive children, only 8.4% had received a clinical diagnosis of dengue, and the ratio of clinically diagnosed cases and subclinical cases was 1 : 11. The seroconversion rate between 2010 and 2011 was 1.4% (CI 3.8% to 35.1%). The seroprevalence of dengue in this pediatric population was low, and the vast majority of cases were not clinically detected, suggesting a difficulty in making the clinical diagnosis in children and a high frequency of asymptomatic infections. |
| format | Article |
| id | doaj-art-2dc10320bb0642c183f2b61e0d2829fa |
| institution | Kabale University |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-2dc10320bb0642c183f2b61e0d2829fa2025-02-03T01:33:05ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982014-01-01201410.1155/2014/703875703875Seroprevalence and Seroconversion of Dengue and Implications for Clinical Diagnosis in Amazonian ChildrenAntonio Camargo Martins0Thasciany Moraes Pereira1Humberto Oliart-Guzmán2Breno Matos Delfino3Saulo Augusto Silva Mantovani4Athos Muniz Braña5Fernando Luiz Cunha Castelo Branco6José Alcântara Filgueira Júnior7Ana Paula Santos8Alanderson Alves Ramalho9Andréia Silva Guimarães10Thiago Santos de Araújo11Cristieli Sérgio de Menezes Oliveira12Benedito Antônio Lopes da Fonseca13Mônica da Silva-Nunes14Centro de Ciências da Saúde e do Desporto, Universidade Federal do Acre, Campus Universitário, BR 364, Bairro Distrito Industrial, 69.919-900 Rio Branco, AC, BrazilCentro de Ciências da Saúde e do Desporto, Universidade Federal do Acre, Campus Universitário, BR 364, Bairro Distrito Industrial, 69.919-900 Rio Branco, AC, BrazilCentro de Ciências da Saúde e do Desporto, Universidade Federal do Acre, Campus Universitário, BR 364, Bairro Distrito Industrial, 69.919-900 Rio Branco, AC, BrazilCentro de Ciências da Saúde e do Desporto, Universidade Federal do Acre, Campus Universitário, BR 364, Bairro Distrito Industrial, 69.919-900 Rio Branco, AC, BrazilCentro de Ciências da Saúde e do Desporto, Universidade Federal do Acre, Campus Universitário, BR 364, Bairro Distrito Industrial, 69.919-900 Rio Branco, AC, BrazilCentro de Ciências da Saúde e do Desporto, Universidade Federal do Acre, Campus Universitário, BR 364, Bairro Distrito Industrial, 69.919-900 Rio Branco, AC, BrazilCentro de Ciências da Saúde e do Desporto, Universidade Federal do Acre, Campus Universitário, BR 364, Bairro Distrito Industrial, 69.919-900 Rio Branco, AC, BrazilCentro de Ciências da Saúde e do Desporto, Universidade Federal do Acre, Campus Universitário, BR 364, Bairro Distrito Industrial, 69.919-900 Rio Branco, AC, BrazilCentro de Ciências da Saúde e do Desporto, Universidade Federal do Acre, Campus Universitário, BR 364, Bairro Distrito Industrial, 69.919-900 Rio Branco, AC, BrazilCentro de Ciências da Saúde e do Desporto, Universidade Federal do Acre, Campus Universitário, BR 364, Bairro Distrito Industrial, 69.919-900 Rio Branco, AC, BrazilCentro de Ciências da Saúde e do Desporto, Universidade Federal do Acre, Campus Universitário, BR 364, Bairro Distrito Industrial, 69.919-900 Rio Branco, AC, BrazilCentro de Ciências da Saúde e do Desporto, Universidade Federal do Acre, Campus Universitário, BR 364, Bairro Distrito Industrial, 69.919-900 Rio Branco, AC, BrazilCentro de Ciências da Saúde e do Desporto, Universidade Federal do Acre, Campus Universitário, BR 364, Bairro Distrito Industrial, 69.919-900 Rio Branco, AC, BrazilFaculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14049-900 Ribeirão Preto, SP, BrazilCentro de Ciências da Saúde e do Desporto, Universidade Federal do Acre, Campus Universitário, BR 364, Bairro Distrito Industrial, 69.919-900 Rio Branco, AC, BrazilThis study aimed to evaluate the prevalence of serum IgG dengue in children in an Amazonian population, to assess the seroconversion rate in 12 months, and to estimate how many seropositive children had a prior clinical diagnosis of dengue. We conducted a population-based study between 2010 and 2011, with children aged 6 months to 12 years that were living in the urban area of a small town in the Brazilian Amazon. The prevalence of IgG antibodies against dengue antigens was determined by indirect ELISA technique, and seronegative children were reexamined after 12 months to determine seroconversion rates. Results showed seroprevalence of IgG antibodies against dengue type of 2.9%, with no significant association between age, race, and sex. In seropositive children, only 8.4% had received a clinical diagnosis of dengue, and the ratio of clinically diagnosed cases and subclinical cases was 1 : 11. The seroconversion rate between 2010 and 2011 was 1.4% (CI 3.8% to 35.1%). The seroprevalence of dengue in this pediatric population was low, and the vast majority of cases were not clinically detected, suggesting a difficulty in making the clinical diagnosis in children and a high frequency of asymptomatic infections.http://dx.doi.org/10.1155/2014/703875 |
| spellingShingle | Antonio Camargo Martins Thasciany Moraes Pereira Humberto Oliart-Guzmán Breno Matos Delfino Saulo Augusto Silva Mantovani Athos Muniz Braña Fernando Luiz Cunha Castelo Branco José Alcântara Filgueira Júnior Ana Paula Santos Alanderson Alves Ramalho Andréia Silva Guimarães Thiago Santos de Araújo Cristieli Sérgio de Menezes Oliveira Benedito Antônio Lopes da Fonseca Mônica da Silva-Nunes Seroprevalence and Seroconversion of Dengue and Implications for Clinical Diagnosis in Amazonian Children Interdisciplinary Perspectives on Infectious Diseases |
| title | Seroprevalence and Seroconversion of Dengue and Implications for Clinical Diagnosis in Amazonian Children |
| title_full | Seroprevalence and Seroconversion of Dengue and Implications for Clinical Diagnosis in Amazonian Children |
| title_fullStr | Seroprevalence and Seroconversion of Dengue and Implications for Clinical Diagnosis in Amazonian Children |
| title_full_unstemmed | Seroprevalence and Seroconversion of Dengue and Implications for Clinical Diagnosis in Amazonian Children |
| title_short | Seroprevalence and Seroconversion of Dengue and Implications for Clinical Diagnosis in Amazonian Children |
| title_sort | seroprevalence and seroconversion of dengue and implications for clinical diagnosis in amazonian children |
| url | http://dx.doi.org/10.1155/2014/703875 |
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