Diabetic nephropathy: Pathophysiology and potential therapeutic role of plant extracts
Objective: This review aims to explore the molecular mechanisms underlying diabetic nephropathy (DN), with a particular focus on the role of oxidative stress. Additionally, it evaluates the therapeutic potential of plant-based extracts rich in bioactive compounds for the management of diabetes and i...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-12-01
|
| Series: | Endocrine and Metabolic Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666396125000494 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850038683004043264 |
|---|---|
| author | Mehak Naseer Mir Ishfaq Ahmad Malik Rayees Ahmad Naik Sonalika Singh Aabid Rashid Hurra Zahid Ahmad Wani Rakhmat Shah Yaqoob Lone |
| author_facet | Mehak Naseer Mir Ishfaq Ahmad Malik Rayees Ahmad Naik Sonalika Singh Aabid Rashid Hurra Zahid Ahmad Wani Rakhmat Shah Yaqoob Lone |
| author_sort | Mehak Naseer Mir |
| collection | DOAJ |
| description | Objective: This review aims to explore the molecular mechanisms underlying diabetic nephropathy (DN), with a particular focus on the role of oxidative stress. Additionally, it evaluates the therapeutic potential of plant-based extracts rich in bioactive compounds for the management of diabetes and its associated renal complications. Results: Oxidative stress is identified as a key contributor to DN pathogenesis. Several major pathways are involved, including hypoxia-inducible factor-1 (HIF-1), transforming growth factor-beta (TGF-β), mitochondrial dysfunction, renin-angiotensin-aldosterone system (RAAS) activation, and endothelial nitric oxide synthase (eNOS) uncoupling. These mechanisms collectively lead to podocyte injury, tubular damage, extracellular matrix accumulation, disrupted renal hemodynamics, and glomerular hyperfiltration. Plant-derived compounds have shown potential in modulating these pathways, thereby offering renal protective effects. Conclusion: Plant-based remedies enriched with bioactive compounds represent promising adjunct therapies for managing diabetes and its renal complications. Their integration into conventional treatment regimens may provide a holistic approach to glycemic control and reduction of oxidative stress-induced kidney damage. This review underscores the importance of multifaceted therapeutic strategies targeting both metabolic dysregulation and oxidative stress to effectively prevent and manage diabetic nephropathy. |
| format | Article |
| id | doaj-art-2dbcaed046754c90b66cabaed93851a1 |
| institution | DOAJ |
| issn | 2666-3961 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Endocrine and Metabolic Science |
| spelling | doaj-art-2dbcaed046754c90b66cabaed93851a12025-08-20T02:56:32ZengElsevierEndocrine and Metabolic Science2666-39612025-12-011910026310.1016/j.endmts.2025.100263Diabetic nephropathy: Pathophysiology and potential therapeutic role of plant extractsMehak Naseer Mir0Ishfaq Ahmad Malik1Rayees Ahmad Naik2Sonalika Singh3Aabid Rashid Hurra4Zahid Ahmad Wani5Rakhmat Shah6Yaqoob Lone7Nims Institute of Allied medical sciences & technology, Nims University Rajasthan, Jaipur 303121, India; Department of Zoology, Government Women College, M.A road Srinagar, 191001 Jammu and Kashmir, India; Department of Zoology, Government Degree College (Autonomous) Baramulla, J&K 193101, IndiaDepartment of Zoology, Bar. R. D. I. K. and K. D. College, Badnera, Maharashtra 444407, IndiaDepartment of Zoology, Dr. Harisingh Gour Central University, Sagar, Madhya Pradesh 470003, IndiaNims Institute of Allied medical sciences & technology, Nims University Rajasthan, Jaipur 303121, IndiaDepartment of Zoology, Government Women College, M.A road Srinagar, 191001 Jammu and Kashmir, India; Department of Zoology, Shri Venkateshwara University, Gajraula, Uttar Pradesh 244236, IndiaDepartment of Zoology, Government Degree College (Autonomous) Baramulla, J&K 193101, India; Department of Zoology, Shri Venkateshwara University, Gajraula, Uttar Pradesh 244236, IndiaDepartment of Zoology, Government Degree College (Autonomous) Baramulla, J&K 193101, IndiaDepartment of Zoology, Government Women College, M.A road Srinagar, 191001 Jammu and Kashmir, India; Department of Zoology, Government Degree College (Autonomous) Baramulla, J&K 193101, India; Corresponding author at: Department of Zoology, Government Women College, M.A road Srinagar, 191001 Jammu and Kashmir, India.Objective: This review aims to explore the molecular mechanisms underlying diabetic nephropathy (DN), with a particular focus on the role of oxidative stress. Additionally, it evaluates the therapeutic potential of plant-based extracts rich in bioactive compounds for the management of diabetes and its associated renal complications. Results: Oxidative stress is identified as a key contributor to DN pathogenesis. Several major pathways are involved, including hypoxia-inducible factor-1 (HIF-1), transforming growth factor-beta (TGF-β), mitochondrial dysfunction, renin-angiotensin-aldosterone system (RAAS) activation, and endothelial nitric oxide synthase (eNOS) uncoupling. These mechanisms collectively lead to podocyte injury, tubular damage, extracellular matrix accumulation, disrupted renal hemodynamics, and glomerular hyperfiltration. Plant-derived compounds have shown potential in modulating these pathways, thereby offering renal protective effects. Conclusion: Plant-based remedies enriched with bioactive compounds represent promising adjunct therapies for managing diabetes and its renal complications. Their integration into conventional treatment regimens may provide a holistic approach to glycemic control and reduction of oxidative stress-induced kidney damage. This review underscores the importance of multifaceted therapeutic strategies targeting both metabolic dysregulation and oxidative stress to effectively prevent and manage diabetic nephropathy.http://www.sciencedirect.com/science/article/pii/S2666396125000494DiabetesKidneyNephropathyOxidative stressBioactive compounds |
| spellingShingle | Mehak Naseer Mir Ishfaq Ahmad Malik Rayees Ahmad Naik Sonalika Singh Aabid Rashid Hurra Zahid Ahmad Wani Rakhmat Shah Yaqoob Lone Diabetic nephropathy: Pathophysiology and potential therapeutic role of plant extracts Endocrine and Metabolic Science Diabetes Kidney Nephropathy Oxidative stress Bioactive compounds |
| title | Diabetic nephropathy: Pathophysiology and potential therapeutic role of plant extracts |
| title_full | Diabetic nephropathy: Pathophysiology and potential therapeutic role of plant extracts |
| title_fullStr | Diabetic nephropathy: Pathophysiology and potential therapeutic role of plant extracts |
| title_full_unstemmed | Diabetic nephropathy: Pathophysiology and potential therapeutic role of plant extracts |
| title_short | Diabetic nephropathy: Pathophysiology and potential therapeutic role of plant extracts |
| title_sort | diabetic nephropathy pathophysiology and potential therapeutic role of plant extracts |
| topic | Diabetes Kidney Nephropathy Oxidative stress Bioactive compounds |
| url | http://www.sciencedirect.com/science/article/pii/S2666396125000494 |
| work_keys_str_mv | AT mehaknaseermir diabeticnephropathypathophysiologyandpotentialtherapeuticroleofplantextracts AT ishfaqahmadmalik diabeticnephropathypathophysiologyandpotentialtherapeuticroleofplantextracts AT rayeesahmadnaik diabeticnephropathypathophysiologyandpotentialtherapeuticroleofplantextracts AT sonalikasingh diabeticnephropathypathophysiologyandpotentialtherapeuticroleofplantextracts AT aabidrashidhurra diabeticnephropathypathophysiologyandpotentialtherapeuticroleofplantextracts AT zahidahmadwani diabeticnephropathypathophysiologyandpotentialtherapeuticroleofplantextracts AT rakhmatshah diabeticnephropathypathophysiologyandpotentialtherapeuticroleofplantextracts AT yaqooblone diabeticnephropathypathophysiologyandpotentialtherapeuticroleofplantextracts |