Combined Cerebellar and Spinal Cord Deficits Caused by an Underlying Gynecologic Malignancy
Paraneoplastic cerebellar degeneration (PCD) is an uncommon autoimmune disorder targeting antigens within the nervous system and is usually associated with an underlying malignancy. Neurologic symptoms frequently precede the cancer diagnosis, which is most often seen in women with breast or gynecolo...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2020/9021843 |
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| author | Tamer Othman Moshe-Samuel Hendizadeh Ritika Vankina Susan Park Phyllis Kim |
| author_facet | Tamer Othman Moshe-Samuel Hendizadeh Ritika Vankina Susan Park Phyllis Kim |
| author_sort | Tamer Othman |
| collection | DOAJ |
| description | Paraneoplastic cerebellar degeneration (PCD) is an uncommon autoimmune disorder targeting antigens within the nervous system and is usually associated with an underlying malignancy. Neurologic symptoms frequently precede the cancer diagnosis, which is most often seen in women with breast or gynecologic tumors. Anti-Yo-related PCD is the most common PCD syndrome, and one of the best understood. Although cerebellar signs are characteristic of anti-Yo PCD, myelopathy is an unusual presentation of anti-Yo PCD based on published case series and reports. Unfortunately, the prognosis for anti-Yo PCD is often poor, and most patients become bedridden. We report a case highlighting a severe presentation of cerebellar degeneration along with an unusual finding of myelopathy in a patient with a newly diagnosed gynecologic cancer. |
| format | Article |
| id | doaj-art-2dbaa7ba9c964246803406f6b63d3f43 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-2dbaa7ba9c964246803406f6b63d3f432025-02-03T06:46:00ZengWileyCase Reports in Oncological Medicine2090-67062090-67142020-01-01202010.1155/2020/90218439021843Combined Cerebellar and Spinal Cord Deficits Caused by an Underlying Gynecologic MalignancyTamer Othman0Moshe-Samuel Hendizadeh1Ritika Vankina2Susan Park3Phyllis Kim4Department of Internal Medicine, Harbor-UCLA Medical Center, Torrance, CA, USADepartment of Neurology, Harbor-UCLA Medical Center, Torrance, CA, USADivision of Hematology and Medical Oncology, Harbor-UCLA Medical Center, Torrance, CA, USADivision of Gynecology Oncology, Harbor-UCLA Medical Center, Torrance, CA, USADepartment of Hematology and Oncology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA, USAParaneoplastic cerebellar degeneration (PCD) is an uncommon autoimmune disorder targeting antigens within the nervous system and is usually associated with an underlying malignancy. Neurologic symptoms frequently precede the cancer diagnosis, which is most often seen in women with breast or gynecologic tumors. Anti-Yo-related PCD is the most common PCD syndrome, and one of the best understood. Although cerebellar signs are characteristic of anti-Yo PCD, myelopathy is an unusual presentation of anti-Yo PCD based on published case series and reports. Unfortunately, the prognosis for anti-Yo PCD is often poor, and most patients become bedridden. We report a case highlighting a severe presentation of cerebellar degeneration along with an unusual finding of myelopathy in a patient with a newly diagnosed gynecologic cancer.http://dx.doi.org/10.1155/2020/9021843 |
| spellingShingle | Tamer Othman Moshe-Samuel Hendizadeh Ritika Vankina Susan Park Phyllis Kim Combined Cerebellar and Spinal Cord Deficits Caused by an Underlying Gynecologic Malignancy Case Reports in Oncological Medicine |
| title | Combined Cerebellar and Spinal Cord Deficits Caused by an Underlying Gynecologic Malignancy |
| title_full | Combined Cerebellar and Spinal Cord Deficits Caused by an Underlying Gynecologic Malignancy |
| title_fullStr | Combined Cerebellar and Spinal Cord Deficits Caused by an Underlying Gynecologic Malignancy |
| title_full_unstemmed | Combined Cerebellar and Spinal Cord Deficits Caused by an Underlying Gynecologic Malignancy |
| title_short | Combined Cerebellar and Spinal Cord Deficits Caused by an Underlying Gynecologic Malignancy |
| title_sort | combined cerebellar and spinal cord deficits caused by an underlying gynecologic malignancy |
| url | http://dx.doi.org/10.1155/2020/9021843 |
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