Small molecules direct the generation of ameloblast-like cells from human embryonic stem cells

Small molecules direct the generation of ameloblast-like cells from human embryonic stem cells

Abstract Background Ameloblasts present a promising avenue for the investigation of enamel and tooth regeneration. Previous protocols for directing the differentiation of human embryonic stem cells (hESCs) into dental epithelial (DE) cells involving the need for additional cells, conditional medium,...

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Bibliographic Details
Main Authors: Ximei Zhu, YiMeng Zhao, Xiaofan Bai, Qiannan Dong, Chunli Tian, Ruilin Sun, Congjuan Yan, Jianping Ruan, Zhongbo Liu, Jianghong Gao
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Stem Cell Research & Therapy
Subjects:
Human embryonic stem cell
Ameloblasts
Small molecules
Spheroids
Online Access:https://doi.org/10.1186/s13287-025-04294-6
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