Role of S-palmitoylation in digestive system diseases
Abstract Digestive system diseases, including liver diseases, gastrointestinal cancers, and inflammatory bowel diseases, pose major health challenges worldwide. These conditions are influenced by a range of key metabolic signaling pathways, many of which are regulated by palmitoylation. Palmitoylati...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-07-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-025-02629-z |
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| author | Hanqing Li Qiuxiang Yuan Shuangshuang Wang Tao Yu Xingsi Qi |
| author_facet | Hanqing Li Qiuxiang Yuan Shuangshuang Wang Tao Yu Xingsi Qi |
| author_sort | Hanqing Li |
| collection | DOAJ |
| description | Abstract Digestive system diseases, including liver diseases, gastrointestinal cancers, and inflammatory bowel diseases, pose major health challenges worldwide. These conditions are influenced by a range of key metabolic signaling pathways, many of which are regulated by palmitoylation. Palmitoylation is a type of lipid modification catalyzed by DHHC palmitoyl S-acyltransferases (DHHC-PTAs) and depalmitoylases, which play critical roles in modulating protein localization, stability, and signal transduction. Dysregulation of S-palmitoylation is closely associated with numerous diseases, including these of the digestive system, through multiple key processes such as immune responses, lipid metabolism, and cellular signaling. Decades of investigations have driven the development of a large body of inhibitors targeting zDHHCs and depalmitoylases, such as S-(2-acetamidoethyl) 2-bromohexadecanethioate (MY-D-4), Artemisinin and Lomitapide. This review provides a comprehensive summary of the role of palmitoylation in digestive system diseases, discusses its effect on disease mechanisms. By elucidating the regulatory functions of palmitoylation under these conditions, this review aimed to identify new strategies for the diagnosis and treatment of digestive system disorders. |
| format | Article |
| id | doaj-art-2db7b78010b74d3bb277f2c5a0e75c2e |
| institution | Kabale University |
| issn | 2058-7716 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj-art-2db7b78010b74d3bb277f2c5a0e75c2e2025-08-20T04:01:46ZengNature Publishing GroupCell Death Discovery2058-77162025-07-0111111810.1038/s41420-025-02629-zRole of S-palmitoylation in digestive system diseasesHanqing Li0Qiuxiang Yuan1Shuangshuang Wang2Tao Yu3Xingsi Qi4Department of Gastroenterology, The People’s Hospital of Qingdao ChengyangDepartment of Gastroenterology, The People’s Hospital of Qingdao ChengyangDepartment of Gastroenterology, The People’s Hospital of Qingdao ChengyangInstitute for Translational Medicine, The Affiliated Hospital of Qingdao UniversityDepartment of Gastroenterology, The Affiliated Hospital of Qingdao UniversityAbstract Digestive system diseases, including liver diseases, gastrointestinal cancers, and inflammatory bowel diseases, pose major health challenges worldwide. These conditions are influenced by a range of key metabolic signaling pathways, many of which are regulated by palmitoylation. Palmitoylation is a type of lipid modification catalyzed by DHHC palmitoyl S-acyltransferases (DHHC-PTAs) and depalmitoylases, which play critical roles in modulating protein localization, stability, and signal transduction. Dysregulation of S-palmitoylation is closely associated with numerous diseases, including these of the digestive system, through multiple key processes such as immune responses, lipid metabolism, and cellular signaling. Decades of investigations have driven the development of a large body of inhibitors targeting zDHHCs and depalmitoylases, such as S-(2-acetamidoethyl) 2-bromohexadecanethioate (MY-D-4), Artemisinin and Lomitapide. This review provides a comprehensive summary of the role of palmitoylation in digestive system diseases, discusses its effect on disease mechanisms. By elucidating the regulatory functions of palmitoylation under these conditions, this review aimed to identify new strategies for the diagnosis and treatment of digestive system disorders.https://doi.org/10.1038/s41420-025-02629-z |
| spellingShingle | Hanqing Li Qiuxiang Yuan Shuangshuang Wang Tao Yu Xingsi Qi Role of S-palmitoylation in digestive system diseases Cell Death Discovery |
| title | Role of S-palmitoylation in digestive system diseases |
| title_full | Role of S-palmitoylation in digestive system diseases |
| title_fullStr | Role of S-palmitoylation in digestive system diseases |
| title_full_unstemmed | Role of S-palmitoylation in digestive system diseases |
| title_short | Role of S-palmitoylation in digestive system diseases |
| title_sort | role of s palmitoylation in digestive system diseases |
| url | https://doi.org/10.1038/s41420-025-02629-z |
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