Integrated Metabolomics and Lipidomics Analysis Reveals the Mechanism Behind the Action of Chiglitazar on the Protection Against Sepsis-Induced Acute Lung Injury

Integrated Metabolomics and Lipidomics Analysis Reveals the Mechanism Behind the Action of Chiglitazar on the Protection Against Sepsis-Induced Acute Lung Injury

<b>Background:</b> Sepsis-induced acute lung injury (SALI) is a critical clinical challenge with high mortality. Metabolic dysregulation drives SALI pathogenesis, disrupting lung function and energy metabolism. Despite proven benefits, metabolic restoration is underused in sepsis. This s...

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Bibliographic Details
Main Authors: Liu-Liu Lu, Yu-Li Cao, Zhen-Chen Lu, Han Wu, Shan-Song Hu, Bing-Qing Ye, Jin-Zhi He, Lei Di, Xu-Lin Chen, Zhi-Cheng Liu
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Metabolites
Subjects:
sepsis-induced acute lung injury
metabolic modulation
metabolic disorder
multi-omics
chiglitazar
Online Access:https://www.mdpi.com/2218-1989/15/5/290
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