Integrated Metabolomics and Lipidomics Analysis Reveals the Mechanism Behind the Action of Chiglitazar on the Protection Against Sepsis-Induced Acute Lung Injury

Integrated Metabolomics and Lipidomics Analysis Reveals the Mechanism Behind the Action of Chiglitazar on the Protection Against Sepsis-Induced Acute Lung Injury

<b>Background:</b> Sepsis-induced acute lung injury (SALI) is a critical clinical challenge with high mortality. Metabolic dysregulation drives SALI pathogenesis, disrupting lung function and energy metabolism. Despite proven benefits, metabolic restoration is underused in sepsis. This s...

Full description

Saved in:

Bibliographic Details
Main Authors:	Liu-Liu Lu, Yu-Li Cao, Zhen-Chen Lu, Han Wu, Shan-Song Hu, Bing-Qing Ye, Jin-Zhi He, Lei Di, Xu-Lin Chen, Zhi-Cheng Liu
Format:	Article
Language:	English
Published:	MDPI AG 2025-04-01
Series:	Metabolites
Subjects:	sepsis-induced acute lung injury metabolic modulation metabolic disorder multi-omics chiglitazar
Online Access:	https://www.mdpi.com/2218-1989/15/5/290
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Chiglitazar diminishes the warburg effect through PPARγ/mTOR/PKM2 and increases the sensitivity of imatinib in chronic myeloid leukemia
by: Hongpeng Duan, et al.
Published: (2024-12-01)

Chiglitazar ameliorates dehydroepiandrosterone-induced polycystic ovary syndrome in rats
by: Fuzhen Zhao, et al.
Published: (2024-11-01)

Administration of chiglitazar reverses chronic stress-induced depressive-like symptoms in mice via activation of hippocampal PPARα and BDNF
by: Jiu-Jian Zhou, et al.
Published: (2025-04-01)

A murine model of acute and prolonged abdominal sepsis, supported by intensive care, reveals time-dependent metabolic alterations in the heart
by: Bart Jacobs, et al.
Published: (2025-01-01)

Sphingolipid metabolism-related genes as diagnostic markers in pneumonia-induced sepsis: the AUG model
by: Jing Wu, et al.
Published: (2025-05-01)

Circulating metabolic biomarkers predict incident sepsis: a large-scale population study in the UK Biobank
by: Hao Bai, et al.
Published: (2025-08-01)

Metabolomics- and proteomics-based multi-omics integration reveals early metabolite alterations in sepsis-associated acute kidney injury
by: Pengfei Huang, et al.
Published: (2025-02-01)

Organ-targeted biomarkers of sepsis: A systematic review reveals the value of inflammation and lipid metabolic dysregulation
by: Zhixin Xu, et al.
Published: (2025-09-01)

Multi-omics decodes host-specific and environmental microbiome interactions in sepsis
by: Jiamin Lu, et al.
Published: (2025-06-01)

Lipidomics and Transcriptomics Analyses Reveal Dietary Complex Plant Extracts Improve Lipid Composition of Back Fat in Sheep
by: Hui Guo, et al.
Published: (2025-06-01)

Metabolomics and transcriptomics analyses reveal the complex molecular mechanisms by which the hypothalamus regulates sexual development in female goats
by: Qing Li, et al.
Published: (2025-03-01)

New insights into the transcription factor regulatory networks driving peel coloration under hormone induction analyzed by transcriptomics and metabolomics in tangor ‘Murcot’
by: Yang Chen, et al.
Published: (2025-02-01)

Prospects for the Management of Sepsis in an Era of Personalised Medicine
by: Jonathan Cohen
Published: (2019-06-01)

Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?
by: Lise Van Wyngene, et al.
Published: (2018-07-01)

From Biomarker Discovery to Clinical Applications of Metabolomics in Glioblastoma
by: Neja Šamec, et al.
Published: (2025-04-01)

Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis
by: Lise Van Wyngene, et al.
Published: (2020-01-01)

Lipidomics and Transcriptomics Revealed Dietary Complex Plant Extracts Improve Lipid Composition of <i>Longissimus dorsi Muscle</i> in Sheep
by: Hui Guo, et al.
Published: (2025-02-01)

Identifying propionate metabolism-related genes as biomarkers of sepsis development and therapeutic targets
by: Lechen Yang, et al.
Published: (2025-07-01)

WMRCA + : a weighted majority rule-based clustering method for cancer subtype prediction using metabolic gene sets
by: Guojun Liu, et al.
Published: (2025-07-01)

The U-shaped relationship between serum osmolality and the risk of sepsis-associated delirium development: a retrospective study
by: Yipeng Fang, et al.
Published: (2025-06-01)

Microbial fertilizers modulate tobacco growth and development through reshaping soil microbiome and metabolome
by: Xiaoyu Wang, et al.
Published: (2025-07-01)

Integration of Network Pharmacology, Transcriptomics, and Metabolomics Strategies to Uncover the Mechanism of Chaihuang Qingfu Pill in Treating Sepsis-Induced Liver Injury
by: Zhang C, et al.
Published: (2025-06-01)

Neonatal Hyperammonemia Due to Ureaplasma Sepsis
by: Catherine A. Kronfol, et al.
Published: (2025-03-01)

Unveiling the molecular mechanisms of Danggui-Shaoyao-San against Alzheimer’s disease in APP/PS1 mice via integrating proteomic and metabolomic approaches
by: Qihui Wu, et al.
Published: (2024-11-01)

SREBF1 mediates immunoparalysis of dendritic cells in sepsis by regulating lipid metabolism and endoplasmic reticulum stress
by: Yaolu Zhang, et al.
Published: (2025-06-01)

AI-driven multi-omics profiling of sepsis immunity in the digestive system
by: Yuan Gao, et al.
Published: (2025-05-01)

Nutritional and Metabolic Status Control and Nutritional Support in Patients with Pancreatic Sepsis (Review)
by: A. V. Zhukov, et al.
Published: (2024-04-01)

Study on the Mechanism of UMI-77 in the Treatment of Sepsis-Induced Acute Lung Injury Based on Transcriptomics and Metabolomics
by: Zhang J, et al.
Published: (2024-12-01)

Comparative lipidomics analysis reveals changes in lipid profile of Arabica coffee at different maturity
by: Yanbing Wang, et al.
Published: (2024-12-01)

A functional analysis of 180 cancer cell lines reveals conserved intrinsic metabolic programs
by: Sarah Cherkaoui, et al.
Published: (2022-11-01)

Combined Analysis of Transcriptome and Mendelian Randomization Reveals AKT1 and PPARG as Biomarkers Related to Glucose Metabolism in Sepsis
by: Ma J, et al.
Published: (2025-07-01)

A machine learning model for robust prediction of sepsis-induced coagulopathy in critically ill patients with sepsis
by: Jia Sun, et al.
Published: (2025-06-01)

Comparative lipidomic and metabolomic profiling of mdx and severe mdx-apolipoprotein e-null mice
by: Ram B. Khattri, et al.
Published: (2024-12-01)

Metabolomic insights into late-life depression: a systematic review
by: Yao Gao, et al.
Published: (2025-08-01)

Integrative lipidomic and transcriptomic analysis unraveled polystyrene nanoplastics-induced liver injury via oral and inhalation exposure: All roads lead to Rome?
by: Yiling Ge, et al.
Published: (2025-08-01)

Multi-omics analysis reveals that low cathepsin S expression aggravates sepsis progression and worse prognosis via inducing monocyte polarization
by: Xiao-Ting Luo, et al.
Published: (2025-03-01)

Genetic, Metabolic, and Proteomic Polymorphisms and Clinical Phenotypes of Sepsis
by: V. A. Kovzel, et al.
Published: (2024-12-01)

Immune cells mediate the effect of plasma lipidomes on IgA nephropathy: a Mendelian randomization study
by: Quanxin Li, et al.
Published: (2025-12-01)

Metabolomics Approach for Sweat Mapping the Performance of Soccer Players in Pretoria, South Africa
by: Nong Malefo, et al.
Published: (2025-04-01)

Single-cell multi-omics-based immune temporal network resolution in sepsis: unravelling molecular mechanisms and precise therapeutic targets
by: Han Liu, et al.
Published: (2025-08-01)