DYNAMICS OF FIBROSIS MARKERS ON THE BACKGROUND OF TB/HIV CO-INFECTION TREATMENT
TB/HIV co - infection remains one of the biggest medical problems in Ukraine and the world. In tuberculosis, MTB stimulates immunocompetent cells to produce MMP-9, which destroys collagen fibers. The inhibitor of MMP-9 is TIMP- 1, and the product of destruction of collagen fibers is oxyproline. In H...
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| Format: | Article |
| Language: | English |
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Academy of Sciences of Moldova
2025-04-01
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| Series: | Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale |
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| Online Access: | https://bulmed.md/bulmed/article/view/3673 |
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| author | Olga SHEVCHENKO Lilia TODORIKO Helen TUDOR Iryna OVCHARENKO Sergiy OVCHARENKO Olga POHORIELOVA |
| author_facet | Olga SHEVCHENKO Lilia TODORIKO Helen TUDOR Iryna OVCHARENKO Sergiy OVCHARENKO Olga POHORIELOVA |
| author_sort | Olga SHEVCHENKO |
| collection | DOAJ |
| description | TB/HIV co - infection remains one of the biggest medical problems in Ukraine and the world. In tuberculosis, MTB stimulates immunocompetent cells to produce MMP-9, which destroys collagen fibers. The inhibitor of MMP-9 is TIMP- 1, and the product of destruction of collagen fibers is oxyproline. In HIV/TB co - infection, the immune response is altered. Therefore, we performed a study of the levels of MMP-9, TIMP-1 and oxyproline in patients with MDR-TB with HIV co -infection. The comparison group included TB patients without HIV. Our research revealed that the level of MMP-9 in patients with MDR-TB remained stable during the study. In patients with HIV/TB co - infection, there is a violation of the regulation of the balance of MMP-9 and TIMP-1, which affects the processes of fibrosis and causes a severe disease course. |
| format | Article |
| id | doaj-art-2db3bebe095f44b68ccb0968ad1ab195 |
| institution | DOAJ |
| issn | 1857-0011 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Academy of Sciences of Moldova |
| record_format | Article |
| series | Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale |
| spelling | doaj-art-2db3bebe095f44b68ccb0968ad1ab1952025-08-20T02:55:49ZengAcademy of Sciences of MoldovaBuletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale1857-00112025-04-017929910310.52692/1857-0011.2024.2-79.183673DYNAMICS OF FIBROSIS MARKERS ON THE BACKGROUND OF TB/HIV CO-INFECTION TREATMENTOlga SHEVCHENKO0Lilia TODORIKO1Helen TUDOR2Iryna OVCHARENKO3Sergiy OVCHARENKO4Olga POHORIELOVA5Kharkiv National Medical UniversityBukovynian State Medical UniversityPMSI Institute of Phthisiopulmonology “Chiril Draganiuc”Kharkiv National Medical UniversityKharkiv National Medical UniversityMNE of KRC “Regional Clinical Psychiatric Hospital No. 3”TB/HIV co - infection remains one of the biggest medical problems in Ukraine and the world. In tuberculosis, MTB stimulates immunocompetent cells to produce MMP-9, which destroys collagen fibers. The inhibitor of MMP-9 is TIMP- 1, and the product of destruction of collagen fibers is oxyproline. In HIV/TB co - infection, the immune response is altered. Therefore, we performed a study of the levels of MMP-9, TIMP-1 and oxyproline in patients with MDR-TB with HIV co -infection. The comparison group included TB patients without HIV. Our research revealed that the level of MMP-9 in patients with MDR-TB remained stable during the study. In patients with HIV/TB co - infection, there is a violation of the regulation of the balance of MMP-9 and TIMP-1, which affects the processes of fibrosis and causes a severe disease course.https://bulmed.md/bulmed/article/view/3673tuberculosishiv infectionmatrix metalloproteinase-9tissue inhibitor of metalloproteinase-1oxyproline |
| spellingShingle | Olga SHEVCHENKO Lilia TODORIKO Helen TUDOR Iryna OVCHARENKO Sergiy OVCHARENKO Olga POHORIELOVA DYNAMICS OF FIBROSIS MARKERS ON THE BACKGROUND OF TB/HIV CO-INFECTION TREATMENT Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale tuberculosis hiv infection matrix metalloproteinase-9 tissue inhibitor of metalloproteinase-1 oxyproline |
| title | DYNAMICS OF FIBROSIS MARKERS ON THE BACKGROUND OF TB/HIV CO-INFECTION TREATMENT |
| title_full | DYNAMICS OF FIBROSIS MARKERS ON THE BACKGROUND OF TB/HIV CO-INFECTION TREATMENT |
| title_fullStr | DYNAMICS OF FIBROSIS MARKERS ON THE BACKGROUND OF TB/HIV CO-INFECTION TREATMENT |
| title_full_unstemmed | DYNAMICS OF FIBROSIS MARKERS ON THE BACKGROUND OF TB/HIV CO-INFECTION TREATMENT |
| title_short | DYNAMICS OF FIBROSIS MARKERS ON THE BACKGROUND OF TB/HIV CO-INFECTION TREATMENT |
| title_sort | dynamics of fibrosis markers on the background of tb hiv co infection treatment |
| topic | tuberculosis hiv infection matrix metalloproteinase-9 tissue inhibitor of metalloproteinase-1 oxyproline |
| url | https://bulmed.md/bulmed/article/view/3673 |
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