High Serum Adipocyte Fatty Acid Binding Protein Is Associated with Metabolic Syndrome in Patients with Type 2 Diabetes
Adipocyte fatty acid binding protein (A-FABP) is a key mediator of obesity-related metabolic syndrome (MetS). The aim of this study was to evaluate the relationship between A-FABP concentration and MetS in type 2 diabetes mellitus (DM) patients. Fasting blood samples were obtained from 165 type 2 DM...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/8380279 |
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| author | Jer-Chuan Li Du-An Wu Jia-Sian Hou Yi-Maun Subeq Hsin-Dean Chen Bang-Gee Hsu |
| author_facet | Jer-Chuan Li Du-An Wu Jia-Sian Hou Yi-Maun Subeq Hsin-Dean Chen Bang-Gee Hsu |
| author_sort | Jer-Chuan Li |
| collection | DOAJ |
| description | Adipocyte fatty acid binding protein (A-FABP) is a key mediator of obesity-related metabolic syndrome (MetS). The aim of this study was to evaluate the relationship between A-FABP concentration and MetS in type 2 diabetes mellitus (DM) patients. Fasting blood samples were obtained from 165 type 2 DM volunteers. MetS and its components were defined using diagnostic criteria from the International Diabetes Federation. Among 165 DM patients, 113 patients (68.5%) had MetS. Diabetic persons who had MetS had significantly higher A-FABP levels (P<0.001) than those without MetS. Female DM persons had higher A-FABP level than man (P<0.001). No statistically significant differences in A-FABP levels were found in use of statin, fibrate, or antidiabetic drugs. Multivariate forward stepwise linear regression analysis revealed that body fat mass (P<0.001), logarithmically transformed creatinine (log-creatinine; P<0.001), female DM patients (P<0.001), and logarithmically transformed high sensitive C-reactive protein (log-hs-CRP; P=0.013) were positively correlated, while albumin (P=0.004) and glomerular filtration rate (GFR; P=0.043) were negatively correlated with serum A-FABP levels in type 2 DM patients. In this study, higher serum A-FABP level was positively associated with MetS in type 2 DM patients. |
| format | Article |
| id | doaj-art-2db330cbd9c74ff493ffabfa94b5612c |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
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| series | Journal of Diabetes Research |
| spelling | doaj-art-2db330cbd9c74ff493ffabfa94b5612c2025-02-03T01:33:29ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/83802798380279High Serum Adipocyte Fatty Acid Binding Protein Is Associated with Metabolic Syndrome in Patients with Type 2 DiabetesJer-Chuan Li0Du-An Wu1Jia-Sian Hou2Yi-Maun Subeq3Hsin-Dean Chen4Bang-Gee Hsu5Division of Metabolism and Endocrinology, Buddhist Tzu Chi General Hospital, Hualien, TaiwanDivision of Metabolism and Endocrinology, Buddhist Tzu Chi General Hospital, Hualien, TaiwanDivision of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, TaiwanInstitute of Medical Sciences, Tzu Chi University, Hualien, TaiwanDivision of Metabolism and Endocrinology, Buddhist Tzu Chi General Hospital, Hualien, TaiwanSchool of Medicine, Tzu Chi University, Hualien, TaiwanAdipocyte fatty acid binding protein (A-FABP) is a key mediator of obesity-related metabolic syndrome (MetS). The aim of this study was to evaluate the relationship between A-FABP concentration and MetS in type 2 diabetes mellitus (DM) patients. Fasting blood samples were obtained from 165 type 2 DM volunteers. MetS and its components were defined using diagnostic criteria from the International Diabetes Federation. Among 165 DM patients, 113 patients (68.5%) had MetS. Diabetic persons who had MetS had significantly higher A-FABP levels (P<0.001) than those without MetS. Female DM persons had higher A-FABP level than man (P<0.001). No statistically significant differences in A-FABP levels were found in use of statin, fibrate, or antidiabetic drugs. Multivariate forward stepwise linear regression analysis revealed that body fat mass (P<0.001), logarithmically transformed creatinine (log-creatinine; P<0.001), female DM patients (P<0.001), and logarithmically transformed high sensitive C-reactive protein (log-hs-CRP; P=0.013) were positively correlated, while albumin (P=0.004) and glomerular filtration rate (GFR; P=0.043) were negatively correlated with serum A-FABP levels in type 2 DM patients. In this study, higher serum A-FABP level was positively associated with MetS in type 2 DM patients.http://dx.doi.org/10.1155/2016/8380279 |
| spellingShingle | Jer-Chuan Li Du-An Wu Jia-Sian Hou Yi-Maun Subeq Hsin-Dean Chen Bang-Gee Hsu High Serum Adipocyte Fatty Acid Binding Protein Is Associated with Metabolic Syndrome in Patients with Type 2 Diabetes Journal of Diabetes Research |
| title | High Serum Adipocyte Fatty Acid Binding Protein Is Associated with Metabolic Syndrome in Patients with Type 2 Diabetes |
| title_full | High Serum Adipocyte Fatty Acid Binding Protein Is Associated with Metabolic Syndrome in Patients with Type 2 Diabetes |
| title_fullStr | High Serum Adipocyte Fatty Acid Binding Protein Is Associated with Metabolic Syndrome in Patients with Type 2 Diabetes |
| title_full_unstemmed | High Serum Adipocyte Fatty Acid Binding Protein Is Associated with Metabolic Syndrome in Patients with Type 2 Diabetes |
| title_short | High Serum Adipocyte Fatty Acid Binding Protein Is Associated with Metabolic Syndrome in Patients with Type 2 Diabetes |
| title_sort | high serum adipocyte fatty acid binding protein is associated with metabolic syndrome in patients with type 2 diabetes |
| url | http://dx.doi.org/10.1155/2016/8380279 |
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