Single-cell transcriptomic analyses reveal heterogeneity and key subsets associated with survival and response to PD-1 blockade in cervical squamous cell carcinoma

Single-cell transcriptomic analyses reveal heterogeneity and key subsets associated with survival and response to PD-1 blockade in cervical squamous cell carcinoma

Abstract Background Understanding the intricate tumor microenvironment (TME) is crucial for elucidating the mechanisms underlying the progression of cervical squamous cell carcinoma (CSCC) and its response to anti-PD-1 therapy. Methods In this study, we characterized 50,649 cells obtained from the C...

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Main Authors: Xia Li, Zhao Zhao, Yanmei Cheng, Jiaqin Yan, Fang Ren, Yanyan Jia, Juanhua Li, Binhui Wang, Junqi Liu, Chenyin Wang, Meimei Gao, Hao Gu, Mingliang Fan, Huirong Shi, Mei Ji, Qitai Zhao
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Cancer Cell International
Subjects:
Cervical squamous cell carcinoma
Single-cell RNA sequencing
Heterogeneity
Tumor-associated epithelial cells
Immunotherapy response
Online Access:https://doi.org/10.1186/s12935-025-03725-x
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