PRAME gene expression profile in medulloblastoma
Medulloblastoma is the most common malignant tumors of central nervous system in the childhood. The treatment is severe, harmful and, thus, has a dismal prognosis. As PRAME is present in various cancers, including meduloblastoma, and has limited expression in normal tissues, this antigen can be an i...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações
2011-02-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000100003&lng=en&tlng=en |
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| _version_ | 1849700106078519296 |
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| author | Tânia Maria Vulcani-Freitas Nasjla Saba-Silva Andréa Cappellano Sérgio Cavalheiro Sílvia Regina Caminada de Toledo |
| author_facet | Tânia Maria Vulcani-Freitas Nasjla Saba-Silva Andréa Cappellano Sérgio Cavalheiro Sílvia Regina Caminada de Toledo |
| author_sort | Tânia Maria Vulcani-Freitas |
| collection | DOAJ |
| description | Medulloblastoma is the most common malignant tumors of central nervous system in the childhood. The treatment is severe, harmful and, thus, has a dismal prognosis. As PRAME is present in various cancers, including meduloblastoma, and has limited expression in normal tissues, this antigen can be an ideal vaccine target for tumor immunotherapy. In order to find a potential molecular target, we investigated PRAME expression in medulloblastoma fragments and we compare the results with the clinical features of each patient. Analysis of gene expression was performed by real-time quantitative PCR from 37 tumor samples. The Mann-Whitney test was used to analysis the relationship between gene expression and clinical characteristics. Kaplan-Meier curves were used to evaluate survival. PRAME was overexpressed in 84% samples. But no statistical association was found between clinical features and PRAME overexpression. Despite that PRAME gene could be a strong candidate for immunotherapy since it is highly expressed in medulloblastomas. |
| format | Article |
| id | doaj-art-2daba8eea31b4ed48e9c582c9b7bc19b |
| institution | DOAJ |
| issn | 1678-4227 |
| language | English |
| publishDate | 2011-02-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-2daba8eea31b4ed48e9c582c9b7bc19b2025-08-20T03:18:23ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272011-02-0169191210.1590/S0004-282X2011000100003S0004-282X2011000100003PRAME gene expression profile in medulloblastomaTânia Maria Vulcani-Freitas0Nasjla Saba-Silva1Andréa Cappellano2Sérgio Cavalheiro3Sílvia Regina Caminada de Toledo4Universidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloMedulloblastoma is the most common malignant tumors of central nervous system in the childhood. The treatment is severe, harmful and, thus, has a dismal prognosis. As PRAME is present in various cancers, including meduloblastoma, and has limited expression in normal tissues, this antigen can be an ideal vaccine target for tumor immunotherapy. In order to find a potential molecular target, we investigated PRAME expression in medulloblastoma fragments and we compare the results with the clinical features of each patient. Analysis of gene expression was performed by real-time quantitative PCR from 37 tumor samples. The Mann-Whitney test was used to analysis the relationship between gene expression and clinical characteristics. Kaplan-Meier curves were used to evaluate survival. PRAME was overexpressed in 84% samples. But no statistical association was found between clinical features and PRAME overexpression. Despite that PRAME gene could be a strong candidate for immunotherapy since it is highly expressed in medulloblastomas.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000100003&lng=en&tlng=enPRAMEexpressão gênicameduloblastomaimunoterapia |
| spellingShingle | Tânia Maria Vulcani-Freitas Nasjla Saba-Silva Andréa Cappellano Sérgio Cavalheiro Sílvia Regina Caminada de Toledo PRAME gene expression profile in medulloblastoma Arquivos de Neuro-Psiquiatria PRAME expressão gênica meduloblastoma imunoterapia |
| title | PRAME gene expression profile in medulloblastoma |
| title_full | PRAME gene expression profile in medulloblastoma |
| title_fullStr | PRAME gene expression profile in medulloblastoma |
| title_full_unstemmed | PRAME gene expression profile in medulloblastoma |
| title_short | PRAME gene expression profile in medulloblastoma |
| title_sort | prame gene expression profile in medulloblastoma |
| topic | PRAME expressão gênica meduloblastoma imunoterapia |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000100003&lng=en&tlng=en |
| work_keys_str_mv | AT taniamariavulcanifreitas pramegeneexpressionprofileinmedulloblastoma AT nasjlasabasilva pramegeneexpressionprofileinmedulloblastoma AT andreacappellano pramegeneexpressionprofileinmedulloblastoma AT sergiocavalheiro pramegeneexpressionprofileinmedulloblastoma AT silviareginacaminadadetoledo pramegeneexpressionprofileinmedulloblastoma |