The Clock and the Brain: Circadian Rhythm and Alzheimer’s Disease
Alzheimer’s Disease (AD) is the most common type of dementia. The circadian system, which is controlled by the master clock in the Suprachiasmatic Nucleus (SCN) of the hypothalamus, is crucial for various physiological processes. Studies have shown that changes in the circadian rhythms can deteriora...
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MDPI AG
2025-07-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/47/7/547 |
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| author | Samaneh Ghorbani Shirkouhi Ashkan Karimi Seyed Sepehr Khatami Ashkan Asgari Gashtrodkhani Farzin Kamari Morten Blaabjerg Sasan Andalib |
| author_facet | Samaneh Ghorbani Shirkouhi Ashkan Karimi Seyed Sepehr Khatami Ashkan Asgari Gashtrodkhani Farzin Kamari Morten Blaabjerg Sasan Andalib |
| author_sort | Samaneh Ghorbani Shirkouhi |
| collection | DOAJ |
| description | Alzheimer’s Disease (AD) is the most common type of dementia. The circadian system, which is controlled by the master clock in the Suprachiasmatic Nucleus (SCN) of the hypothalamus, is crucial for various physiological processes. Studies have shown that changes in the circadian rhythms can deteriorate neurodegenerative diseases. Changes in the SCN are associated with cognitive decline in AD. The cognitive impairments in AD, especially memory dysfunctions, may be related to Circadian Rhythm Disturbances (CRDs). Moreover, rhythmic expression of clock genes is disrupted in AD patients. There is a circadian pattern of inflammatory processes in AD, and dysregulation of core clock genes promotes neuroinflammation. The present narrative review addresses the intricate link between CRDs and AD, revisiting the relevant cellular and molecular mechanisms. The association between CRDs and AD highlights the need for further investigation of the underlying mechanisms. |
| format | Article |
| id | doaj-art-2dab5b2cc3d64775892416137dfdf14e |
| institution | Kabale University |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj-art-2dab5b2cc3d64775892416137dfdf14e2025-08-20T03:58:31ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452025-07-0147754710.3390/cimb47070547The Clock and the Brain: Circadian Rhythm and Alzheimer’s DiseaseSamaneh Ghorbani Shirkouhi0Ashkan Karimi1Seyed Sepehr Khatami2Ashkan Asgari Gashtrodkhani3Farzin Kamari4Morten Blaabjerg5Sasan Andalib6Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud 36147-73943, IranDepartment of Psychology, Centre for Vision Research, York University, Toronto, ON M3J 1P3, CanadaDepartment of Neurology, University of California Irvine, Irvine, CA 92617, USASchool of Medicine, Guilan University of Medical Sciences, Rasht 41937-13111, IranDepartment of Neurophysiology, Institute of Physiology, Eberhard Karls University of Tuebingen, 72074 Tuebingen, GermanyResearch Unit of Neurology, Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, 5230 Odense, DenmarkResearch Unit of Neurology, Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, 5230 Odense, DenmarkAlzheimer’s Disease (AD) is the most common type of dementia. The circadian system, which is controlled by the master clock in the Suprachiasmatic Nucleus (SCN) of the hypothalamus, is crucial for various physiological processes. Studies have shown that changes in the circadian rhythms can deteriorate neurodegenerative diseases. Changes in the SCN are associated with cognitive decline in AD. The cognitive impairments in AD, especially memory dysfunctions, may be related to Circadian Rhythm Disturbances (CRDs). Moreover, rhythmic expression of clock genes is disrupted in AD patients. There is a circadian pattern of inflammatory processes in AD, and dysregulation of core clock genes promotes neuroinflammation. The present narrative review addresses the intricate link between CRDs and AD, revisiting the relevant cellular and molecular mechanisms. The association between CRDs and AD highlights the need for further investigation of the underlying mechanisms.https://www.mdpi.com/1467-3045/47/7/547circadian rhythmAlzheimer’s Diseasemolecular mechanismscellular mechanisms |
| spellingShingle | Samaneh Ghorbani Shirkouhi Ashkan Karimi Seyed Sepehr Khatami Ashkan Asgari Gashtrodkhani Farzin Kamari Morten Blaabjerg Sasan Andalib The Clock and the Brain: Circadian Rhythm and Alzheimer’s Disease Current Issues in Molecular Biology circadian rhythm Alzheimer’s Disease molecular mechanisms cellular mechanisms |
| title | The Clock and the Brain: Circadian Rhythm and Alzheimer’s Disease |
| title_full | The Clock and the Brain: Circadian Rhythm and Alzheimer’s Disease |
| title_fullStr | The Clock and the Brain: Circadian Rhythm and Alzheimer’s Disease |
| title_full_unstemmed | The Clock and the Brain: Circadian Rhythm and Alzheimer’s Disease |
| title_short | The Clock and the Brain: Circadian Rhythm and Alzheimer’s Disease |
| title_sort | clock and the brain circadian rhythm and alzheimer s disease |
| topic | circadian rhythm Alzheimer’s Disease molecular mechanisms cellular mechanisms |
| url | https://www.mdpi.com/1467-3045/47/7/547 |
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