Case report: Cervical suppurative lymphadenitis caused by burkholderia multivorans in a healthy child
Abstract Background Cervical suppurative lymphadenitis in children is commonly caused by Staphylococcus aureus or Streptococcus pyogenes. However, cases caused by Burkholderia multivorans (BM) are rare. The clinical presentation lacks specificity, making it difficult for clinicians to recognize, whi...
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| Format: | Article |
| Language: | English |
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BMC
2025-05-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-025-11033-y |
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| author | Bei-bei Niu Jing-jing Xu Ji-an Li Ling-dong Zhu |
| author_facet | Bei-bei Niu Jing-jing Xu Ji-an Li Ling-dong Zhu |
| author_sort | Bei-bei Niu |
| collection | DOAJ |
| description | Abstract Background Cervical suppurative lymphadenitis in children is commonly caused by Staphylococcus aureus or Streptococcus pyogenes. However, cases caused by Burkholderia multivorans (BM) are rare. The clinical presentation lacks specificity, making it difficult for clinicians to recognize, which may delay diagnosis and treatment. Case presentation We report a case of a 5-year-old boy admitted with recurrent fever and neck swelling. Initial treatment with meropenem and linezolid was ineffective, and symptoms persisted after 24 days of conservative therapy. Aspiration of pus yielded negative culture results. Definitive diagnosis was achieved through surgical biopsy of cervical lymph nodes, pathological examination, and metagenomic next-generation sequencing (mNGS), which identified BM as the causative pathogen. The patient was successfully treated with a combination of trimethoprim-sulfamethoxazole and meropenem. The cervical lesion exhibited granulomatous inflammation and was managed with adjunctive vacuum-assisted closure (VAC) therapy, resulting in complete wound healing without recurrence. Conclusions This study aims to raise awareness among all specialists about BM as a potential causative agent in cervical suppurative lymphadenitis. Early recognition and timely intervention can reduce misdiagnosis and missed diagnoses, improving patient outcomes. |
| format | Article |
| id | doaj-art-2da8dc8e72a3454dbb2fa1484a995817 |
| institution | DOAJ |
| issn | 1471-2334 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj-art-2da8dc8e72a3454dbb2fa1484a9958172025-08-20T03:09:35ZengBMCBMC Infectious Diseases1471-23342025-05-012511710.1186/s12879-025-11033-yCase report: Cervical suppurative lymphadenitis caused by burkholderia multivorans in a healthy childBei-bei Niu0Jing-jing Xu1Ji-an Li2Ling-dong Zhu3Department of Plastic and Burn Surgery, Children’s Hospital Affiliated to Shandong University (Jinan Children’s Hospital)Department of Plastic and Burn Surgery, Children’s Hospital Affiliated to Shandong University (Jinan Children’s Hospital)Infectious Diseases Department, Children’s Hospital Affiliated to Shandong University (Jinan Children’s Hospital)Department of Plastic and Burn Surgery, Children’s Hospital Affiliated to Shandong University (Jinan Children’s Hospital)Abstract Background Cervical suppurative lymphadenitis in children is commonly caused by Staphylococcus aureus or Streptococcus pyogenes. However, cases caused by Burkholderia multivorans (BM) are rare. The clinical presentation lacks specificity, making it difficult for clinicians to recognize, which may delay diagnosis and treatment. Case presentation We report a case of a 5-year-old boy admitted with recurrent fever and neck swelling. Initial treatment with meropenem and linezolid was ineffective, and symptoms persisted after 24 days of conservative therapy. Aspiration of pus yielded negative culture results. Definitive diagnosis was achieved through surgical biopsy of cervical lymph nodes, pathological examination, and metagenomic next-generation sequencing (mNGS), which identified BM as the causative pathogen. The patient was successfully treated with a combination of trimethoprim-sulfamethoxazole and meropenem. The cervical lesion exhibited granulomatous inflammation and was managed with adjunctive vacuum-assisted closure (VAC) therapy, resulting in complete wound healing without recurrence. Conclusions This study aims to raise awareness among all specialists about BM as a potential causative agent in cervical suppurative lymphadenitis. Early recognition and timely intervention can reduce misdiagnosis and missed diagnoses, improving patient outcomes.https://doi.org/10.1186/s12879-025-11033-yCervical suppurative lymphadenitisBurkholderia multivoransHealthy childPrecise diagnosisGranulomatous inflammation |
| spellingShingle | Bei-bei Niu Jing-jing Xu Ji-an Li Ling-dong Zhu Case report: Cervical suppurative lymphadenitis caused by burkholderia multivorans in a healthy child BMC Infectious Diseases Cervical suppurative lymphadenitis Burkholderia multivorans Healthy child Precise diagnosis Granulomatous inflammation |
| title | Case report: Cervical suppurative lymphadenitis caused by burkholderia multivorans in a healthy child |
| title_full | Case report: Cervical suppurative lymphadenitis caused by burkholderia multivorans in a healthy child |
| title_fullStr | Case report: Cervical suppurative lymphadenitis caused by burkholderia multivorans in a healthy child |
| title_full_unstemmed | Case report: Cervical suppurative lymphadenitis caused by burkholderia multivorans in a healthy child |
| title_short | Case report: Cervical suppurative lymphadenitis caused by burkholderia multivorans in a healthy child |
| title_sort | case report cervical suppurative lymphadenitis caused by burkholderia multivorans in a healthy child |
| topic | Cervical suppurative lymphadenitis Burkholderia multivorans Healthy child Precise diagnosis Granulomatous inflammation |
| url | https://doi.org/10.1186/s12879-025-11033-y |
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