Cerebral Metastasis from a Previously Undiagnosed Appendiceal Adenocarcinoma
Brain metastases arise in 10%–40% of all cancer patients. Up to one third of the patients do not have previous cancer history. We report a case of a 67-years-old male patient who presented with confusion, tremor, and apraxia. A brain MRI revealed an isolated right temporal lobe lesion. A thorax-abdo...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/192807 |
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| author | Antonio Biroli Paolo Cipriano Cecchi Susanne Pragal Esther Hanspeter Andreas Schwarz |
| author_facet | Antonio Biroli Paolo Cipriano Cecchi Susanne Pragal Esther Hanspeter Andreas Schwarz |
| author_sort | Antonio Biroli |
| collection | DOAJ |
| description | Brain metastases arise in 10%–40% of all cancer patients. Up to one third of the patients do not have previous cancer history. We report a case of a 67-years-old male patient who presented with confusion, tremor, and apraxia. A brain MRI revealed an isolated right temporal lobe lesion. A thorax-abdomen-pelvis CT scan showed no primary lesion. The patient underwent a craniotomy with gross-total resection. Histopathology revealed an intestinal-type adenocarcinoma. A colonoscopy found no primary lesion, but a PET-CT scan showed elevated FDG uptake in the appendiceal nodule. A right hemicolectomy was performed, and the specimen showed a moderately differentiated mucinous appendiceal adenocarcinoma. Whole brain radiotherapy was administrated. A subsequent thorax-abdomen CT scan revealed multiple lung and hepatic metastasis. Seven months later, the patient died of disease progression. In cases of undiagnosed primary lesions, patients present in better general condition, but overall survival does not change. Eventual identification of the primary tumor does not affect survival. PET/CT might be a helpful tool in detecting lesions of the appendiceal region. To the best of our knowledge, such a case was never reported in the literature, and an appendiceal malignancy should be suspected in patients with brain metastasis from an undiagnosed primary tumor. |
| format | Article |
| id | doaj-art-2da74fa698134e3c90ac55644ac1149f |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-2da74fa698134e3c90ac55644ac1149f2025-02-03T01:32:18ZengWileyCase Reports in Oncological Medicine2090-67062090-67142012-01-01201210.1155/2012/192807192807Cerebral Metastasis from a Previously Undiagnosed Appendiceal AdenocarcinomaAntonio Biroli0Paolo Cipriano Cecchi1Susanne Pragal2Esther Hanspeter3Andreas Schwarz4Department of Neurosurgery, University Hospital, 37126 Verona, ItalyOperative Unit of Neurosurgery, Regional General Hospital, Via L. Boehler 5, 39100 Bolzano, ItalyInternal Medicine, General Hospital, 39028 Silandro, ItalyService of Pathology, Regional General Hospital, 39100 Bolzano, ItalyOperative Unit of Neurosurgery, Regional General Hospital, Via L. Boehler 5, 39100 Bolzano, ItalyBrain metastases arise in 10%–40% of all cancer patients. Up to one third of the patients do not have previous cancer history. We report a case of a 67-years-old male patient who presented with confusion, tremor, and apraxia. A brain MRI revealed an isolated right temporal lobe lesion. A thorax-abdomen-pelvis CT scan showed no primary lesion. The patient underwent a craniotomy with gross-total resection. Histopathology revealed an intestinal-type adenocarcinoma. A colonoscopy found no primary lesion, but a PET-CT scan showed elevated FDG uptake in the appendiceal nodule. A right hemicolectomy was performed, and the specimen showed a moderately differentiated mucinous appendiceal adenocarcinoma. Whole brain radiotherapy was administrated. A subsequent thorax-abdomen CT scan revealed multiple lung and hepatic metastasis. Seven months later, the patient died of disease progression. In cases of undiagnosed primary lesions, patients present in better general condition, but overall survival does not change. Eventual identification of the primary tumor does not affect survival. PET/CT might be a helpful tool in detecting lesions of the appendiceal region. To the best of our knowledge, such a case was never reported in the literature, and an appendiceal malignancy should be suspected in patients with brain metastasis from an undiagnosed primary tumor.http://dx.doi.org/10.1155/2012/192807 |
| spellingShingle | Antonio Biroli Paolo Cipriano Cecchi Susanne Pragal Esther Hanspeter Andreas Schwarz Cerebral Metastasis from a Previously Undiagnosed Appendiceal Adenocarcinoma Case Reports in Oncological Medicine |
| title | Cerebral Metastasis from a Previously Undiagnosed Appendiceal Adenocarcinoma |
| title_full | Cerebral Metastasis from a Previously Undiagnosed Appendiceal Adenocarcinoma |
| title_fullStr | Cerebral Metastasis from a Previously Undiagnosed Appendiceal Adenocarcinoma |
| title_full_unstemmed | Cerebral Metastasis from a Previously Undiagnosed Appendiceal Adenocarcinoma |
| title_short | Cerebral Metastasis from a Previously Undiagnosed Appendiceal Adenocarcinoma |
| title_sort | cerebral metastasis from a previously undiagnosed appendiceal adenocarcinoma |
| url | http://dx.doi.org/10.1155/2012/192807 |
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