Enhancement of chlorpromazine efficacy in breast cancer treatment by 266 nm laser irradiation
Abstract Breast cancer remains a global health challenge, prompting interest in the anticancer properties of other drugs, including chlorpromazine (CPZ). This study presents a novel approach in breast cancer treatment using laser irradiated CPZ. CPZ dissolved in distilled water, was exposed to 266 n...
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Nature Portfolio
2024-12-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-82088-1 |
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| _version_ | 1850136622168801280 |
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| author | Ana Maria Udrea Angela Staicu Adriana Smarandache Ionut Relu Andrei Madalina Andreea Badea Speranta Avram Mihail Lucian Pascu Ruxandra Angela Pirvulescu Mihaela Balas |
| author_facet | Ana Maria Udrea Angela Staicu Adriana Smarandache Ionut Relu Andrei Madalina Andreea Badea Speranta Avram Mihail Lucian Pascu Ruxandra Angela Pirvulescu Mihaela Balas |
| author_sort | Ana Maria Udrea |
| collection | DOAJ |
| description | Abstract Breast cancer remains a global health challenge, prompting interest in the anticancer properties of other drugs, including chlorpromazine (CPZ). This study presents a novel approach in breast cancer treatment using laser irradiated CPZ. CPZ dissolved in distilled water, was exposed to 266 nm laser irradiation for varying durations, characterized by UV-Vis and FTIR spectroscopy, followed by drug-likeness and ADME-Tox predictions. In vitro assays evaluated the cytotoxicity and cellular effects on MCF-7 breast cancer cells, and compared with MCF-12 A healthy cell line. Laser irradiation altered CPZ molecular structure resulting in photoproducts with favourable drug-like properties and ADME-Tox profiles. In vitro evaluations demonstrate dose and irradiation time-dependent cytotoxicity against breast cancer cells, and reduced toxicity on healthy cell line. Significant alterations in F-actin organization, and excessive ROS generation were also proved, suggesting the potential of laser-modified CPZ for breast cancer therapy. This study introduces a novel approach to breast cancer treatment through laser irradiated CPZ, highlighting promising advancements in therapy and emphasizing the role of laser-generated compounds. |
| format | Article |
| id | doaj-art-2da2e62ee36047a89f20c8cc061a562e |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-2da2e62ee36047a89f20c8cc061a562e2025-08-20T02:31:04ZengNature PortfolioScientific Reports2045-23222024-12-0114111610.1038/s41598-024-82088-1Enhancement of chlorpromazine efficacy in breast cancer treatment by 266 nm laser irradiationAna Maria Udrea0Angela Staicu1Adriana Smarandache2Ionut Relu Andrei3Madalina Andreea Badea4Speranta Avram5Mihail Lucian Pascu6Ruxandra Angela Pirvulescu7Mihaela Balas8National Institute for Laser, Plasma and Radiation Physics (INFLPR)National Institute for Laser, Plasma and Radiation Physics (INFLPR)National Institute for Laser, Plasma and Radiation Physics (INFLPR)National Institute for Laser, Plasma and Radiation Physics (INFLPR)Department of Biochemistry and Molecular Biology, Faculty of Biology, University of BucharestDepartment of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of BucharestNational Institute for Laser, Plasma and Radiation Physics (INFLPR)Carol Davila University of Medicine and PharmacyDepartment of Biochemistry and Molecular Biology, Faculty of Biology, University of BucharestAbstract Breast cancer remains a global health challenge, prompting interest in the anticancer properties of other drugs, including chlorpromazine (CPZ). This study presents a novel approach in breast cancer treatment using laser irradiated CPZ. CPZ dissolved in distilled water, was exposed to 266 nm laser irradiation for varying durations, characterized by UV-Vis and FTIR spectroscopy, followed by drug-likeness and ADME-Tox predictions. In vitro assays evaluated the cytotoxicity and cellular effects on MCF-7 breast cancer cells, and compared with MCF-12 A healthy cell line. Laser irradiation altered CPZ molecular structure resulting in photoproducts with favourable drug-like properties and ADME-Tox profiles. In vitro evaluations demonstrate dose and irradiation time-dependent cytotoxicity against breast cancer cells, and reduced toxicity on healthy cell line. Significant alterations in F-actin organization, and excessive ROS generation were also proved, suggesting the potential of laser-modified CPZ for breast cancer therapy. This study introduces a novel approach to breast cancer treatment through laser irradiated CPZ, highlighting promising advancements in therapy and emphasizing the role of laser-generated compounds.https://doi.org/10.1038/s41598-024-82088-1ChlorpromazineBreast cancerDrug repositioningLaser-irradiated drugsAntipsychotic drugsADME-Tox |
| spellingShingle | Ana Maria Udrea Angela Staicu Adriana Smarandache Ionut Relu Andrei Madalina Andreea Badea Speranta Avram Mihail Lucian Pascu Ruxandra Angela Pirvulescu Mihaela Balas Enhancement of chlorpromazine efficacy in breast cancer treatment by 266 nm laser irradiation Scientific Reports Chlorpromazine Breast cancer Drug repositioning Laser-irradiated drugs Antipsychotic drugs ADME-Tox |
| title | Enhancement of chlorpromazine efficacy in breast cancer treatment by 266 nm laser irradiation |
| title_full | Enhancement of chlorpromazine efficacy in breast cancer treatment by 266 nm laser irradiation |
| title_fullStr | Enhancement of chlorpromazine efficacy in breast cancer treatment by 266 nm laser irradiation |
| title_full_unstemmed | Enhancement of chlorpromazine efficacy in breast cancer treatment by 266 nm laser irradiation |
| title_short | Enhancement of chlorpromazine efficacy in breast cancer treatment by 266 nm laser irradiation |
| title_sort | enhancement of chlorpromazine efficacy in breast cancer treatment by 266 nm laser irradiation |
| topic | Chlorpromazine Breast cancer Drug repositioning Laser-irradiated drugs Antipsychotic drugs ADME-Tox |
| url | https://doi.org/10.1038/s41598-024-82088-1 |
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