Synthesis, Crystal Structures, and DNA Binding Properties of Zinc(II) Complexes with 3-Pyridine Aldoxime
The employment of 3-pyridine aldoxime, (3-py)CHNOH, in ZnII chemistry has afforded two novel compounds: [Zn(acac)2{(3-py)CHNOH}]⋅H2O (1⋅H2O) [where acac- is the pentane-2,4-dionato(-1) ion] and [Zn2(O2CMe)4{(3-py)CHNOH}2] (2). Complex 1⋅H2O crystallizes in the monoclinic space group P21/n. The ZnII...
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| Format: | Article |
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Wiley
2010-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2010/803424 |
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| author | Konstantis F. Konidaris Rigini Papi Eugenia Katsoulakou Catherine P. Raptopoulou Dimitrios A. Kyriakidis Evy Manessi-Zoupa |
| author_facet | Konstantis F. Konidaris Rigini Papi Eugenia Katsoulakou Catherine P. Raptopoulou Dimitrios A. Kyriakidis Evy Manessi-Zoupa |
| author_sort | Konstantis F. Konidaris |
| collection | DOAJ |
| description | The employment of 3-pyridine aldoxime, (3-py)CHNOH, in ZnII chemistry has afforded two novel compounds: [Zn(acac)2{(3-py)CHNOH}]⋅H2O (1⋅H2O) [where acac- is the pentane-2,4-dionato(-1) ion] and [Zn2(O2CMe)4{(3-py)CHNOH}2] (2). Complex 1⋅H2O crystallizes in the monoclinic space group P21/n. The ZnII ion is five-coordinated, surrounded by four oxygen atoms of two acac- moieties and by the pyridyl nitrogen atom of the (3-py)CHNOH ligand. Molecules of 1 interact with the water lattice molecules forming a 2D hydrogen-bonding network. Complex 2 crystallizes in the triclinic P-1 space group and displays a dinuclear paddle-wheel structure. Each ZnII exhibits a perfect square pyramidal geometry, with four carboxylate oxygen atoms at the basal plane and the pyridyl nitrogen of one monodentate (3-py)CHNOH ligand at the apex. DNA mobility shift assays were performed for the determination of the in vitro effect of both complexes on the integrity and the electrophoretic mobility of pDNA. |
| format | Article |
| id | doaj-art-2da275a17891436fbfa2818e950f040f |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-2da275a17891436fbfa2818e950f040f2025-02-03T05:50:09ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2010-01-01201010.1155/2010/803424803424Synthesis, Crystal Structures, and DNA Binding Properties of Zinc(II) Complexes with 3-Pyridine AldoximeKonstantis F. Konidaris0Rigini Papi1Eugenia Katsoulakou2Catherine P. Raptopoulou3Dimitrios A. Kyriakidis4Evy Manessi-Zoupa5Department of Chemistry, University of Patras, 265 04 Patras, GreeceDepartment of Chemistry, Aristotle University of Thessaloniki, 541 24 Thessaloniki, GreeceDepartment of Chemistry, University of Patras, 265 04 Patras, GreeceInstitute of Materials Science, NCSR “Demokritos”, 153 10 Aghia Paraskevi Attikis, GreeceDepartment of Chemistry, Aristotle University of Thessaloniki, 541 24 Thessaloniki, GreeceDepartment of Chemistry, University of Patras, 265 04 Patras, GreeceThe employment of 3-pyridine aldoxime, (3-py)CHNOH, in ZnII chemistry has afforded two novel compounds: [Zn(acac)2{(3-py)CHNOH}]⋅H2O (1⋅H2O) [where acac- is the pentane-2,4-dionato(-1) ion] and [Zn2(O2CMe)4{(3-py)CHNOH}2] (2). Complex 1⋅H2O crystallizes in the monoclinic space group P21/n. The ZnII ion is five-coordinated, surrounded by four oxygen atoms of two acac- moieties and by the pyridyl nitrogen atom of the (3-py)CHNOH ligand. Molecules of 1 interact with the water lattice molecules forming a 2D hydrogen-bonding network. Complex 2 crystallizes in the triclinic P-1 space group and displays a dinuclear paddle-wheel structure. Each ZnII exhibits a perfect square pyramidal geometry, with four carboxylate oxygen atoms at the basal plane and the pyridyl nitrogen of one monodentate (3-py)CHNOH ligand at the apex. DNA mobility shift assays were performed for the determination of the in vitro effect of both complexes on the integrity and the electrophoretic mobility of pDNA.http://dx.doi.org/10.1155/2010/803424 |
| spellingShingle | Konstantis F. Konidaris Rigini Papi Eugenia Katsoulakou Catherine P. Raptopoulou Dimitrios A. Kyriakidis Evy Manessi-Zoupa Synthesis, Crystal Structures, and DNA Binding Properties of Zinc(II) Complexes with 3-Pyridine Aldoxime Bioinorganic Chemistry and Applications |
| title | Synthesis, Crystal Structures, and DNA Binding Properties of Zinc(II) Complexes with 3-Pyridine Aldoxime |
| title_full | Synthesis, Crystal Structures, and DNA Binding Properties of Zinc(II) Complexes with 3-Pyridine Aldoxime |
| title_fullStr | Synthesis, Crystal Structures, and DNA Binding Properties of Zinc(II) Complexes with 3-Pyridine Aldoxime |
| title_full_unstemmed | Synthesis, Crystal Structures, and DNA Binding Properties of Zinc(II) Complexes with 3-Pyridine Aldoxime |
| title_short | Synthesis, Crystal Structures, and DNA Binding Properties of Zinc(II) Complexes with 3-Pyridine Aldoxime |
| title_sort | synthesis crystal structures and dna binding properties of zinc ii complexes with 3 pyridine aldoxime |
| url | http://dx.doi.org/10.1155/2010/803424 |
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