Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments
Metabolic dysfunction-associated steatosic liver disease (MASLD) poses a global health challenge with limited therapeutic options. Hesperetin, a flavonoid extracted from citrus, exhibits multiple pharmacological properties, but its mechanisms in MASLD-associated lipid metabolism remain unclear. This...
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| Format: | Article |
| Language: | English |
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De Gruyter
2025-06-01
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| Series: | Open Medicine |
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| Online Access: | https://doi.org/10.1515/med-2025-1215 |
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| _version_ | 1850220550922698752 |
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| author | Wu Yi Lin Ying Xu Shan Su Dan Yang Hao Tang Lidan |
| author_facet | Wu Yi Lin Ying Xu Shan Su Dan Yang Hao Tang Lidan |
| author_sort | Wu Yi |
| collection | DOAJ |
| description | Metabolic dysfunction-associated steatosic liver disease (MASLD) poses a global health challenge with limited therapeutic options. Hesperetin, a flavonoid extracted from citrus, exhibits multiple pharmacological properties, but its mechanisms in MASLD-associated lipid metabolism remain unclear. This study aimed to explore the mechanism of hesperetin for treating MASLD. |
| format | Article |
| id | doaj-art-2d9ddd9938cf464598bf20976224cd38 |
| institution | OA Journals |
| issn | 2391-5463 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj-art-2d9ddd9938cf464598bf20976224cd382025-08-20T02:07:02ZengDe GruyterOpen Medicine2391-54632025-06-01201202910.1515/med-2025-1215Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experimentsWu Yi0Lin Ying1Xu Shan2Su Dan3Yang Hao4Tang Lidan5Department of Pharmacy, The Second People’s Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu, 213164, ChinaDepartment of Pharmacy, The Second People’s Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu, 213164, ChinaDepartment of Pharmacy, The Second People’s Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu, 213164, ChinaDepartment of Pharmacy, The Second People’s Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu, 213164, ChinaDepartment of Pharmacy, The Second People’s Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, No. 68. Gehu Middle Road, Changzhou, Jiangsu, 213164, ChinaDepartment of Pharmacy, The Second People’s Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu, 213164, ChinaMetabolic dysfunction-associated steatosic liver disease (MASLD) poses a global health challenge with limited therapeutic options. Hesperetin, a flavonoid extracted from citrus, exhibits multiple pharmacological properties, but its mechanisms in MASLD-associated lipid metabolism remain unclear. This study aimed to explore the mechanism of hesperetin for treating MASLD.https://doi.org/10.1515/med-2025-1215hesperetinmasldil-6-stat3-socs3 signaling pathwaylipid metabolismnetwork pharmacology |
| spellingShingle | Wu Yi Lin Ying Xu Shan Su Dan Yang Hao Tang Lidan Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments Open Medicine hesperetin masld il-6-stat3-socs3 signaling pathway lipid metabolism network pharmacology |
| title | Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments |
| title_full | Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments |
| title_fullStr | Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments |
| title_full_unstemmed | Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments |
| title_short | Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments |
| title_sort | mechanisms of hesperetin in treating metabolic dysfunction associated steatosis liver disease via network pharmacology and in vitro experiments |
| topic | hesperetin masld il-6-stat3-socs3 signaling pathway lipid metabolism network pharmacology |
| url | https://doi.org/10.1515/med-2025-1215 |
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