Association of TyG index with mortality at 28 days in sepsis patients in intensive care from MIMIC IV database
Abstract The relationship between the triglyceride‒glucose (TyG) index and the clinical prognosis of septic patients in intensive care units (ICUs) remains unclear. This study aimed to explore the correlation between the TyG index and 28-day all-cause mortality in septic patients. A retrospective ob...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-86746-w |
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| author | Heping Xu Jinyuan Xie Yan Xia Huan Niu Hong Wang Feng Zhan |
| author_facet | Heping Xu Jinyuan Xie Yan Xia Huan Niu Hong Wang Feng Zhan |
| author_sort | Heping Xu |
| collection | DOAJ |
| description | Abstract The relationship between the triglyceride‒glucose (TyG) index and the clinical prognosis of septic patients in intensive care units (ICUs) remains unclear. This study aimed to explore the correlation between the TyG index and 28-day all-cause mortality in septic patients. A retrospective observational cohort study was conducted, including 8955 septic patients from the MIMIC IV 2.2 database. The primary outcome was 28-day all-cause mortality. Multivariate logistic regression analysis and restricted cubic spline regression analysis were used to assess the relationship between the TyG index and 28-day all-cause mortality in septic patients. Subgroup analyses and sensitivity analyses were performed to further validate the robustness of the results. A total of 8955 septic patients were included, 5219 (58.3%) of whom were male, with a mean age of 66.3 (15.8) years and an average TyG index of 9.08 (0.70) and the number of deaths within 28 days was 1639 (18.3%). The RCS curve demonstrated a U-shaped relationship between the TyG index and 28-day all-cause mortality (nonlinear P value = 0.0003). The risk of 28-day all-cause mortality was negatively associated with the TyG index until it decreased to 9.03 (adjusted odds ratio [OR] 0.727, 95% confidence interval [CI] 0.577–0.915). However, when the TyG index exceeded 9.03, the odds ratio for 28-day all-cause mortality significantly increased (adjusted OR 1.185, 95% CI 1.001–1.404). These findings were consistent across subgroups and various sensitivity analyses. Our study revealed a nonlinear U-shaped relationship between the TyG index and 28-day all-cause mortality, with a critical point at a TyG index of 9.03. Our results suggest that the TyG index may be a novel and important factor for the short-term clinical prognosis of critically ill septic patients. |
| format | Article |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-2d98f1e69bae4341b74e5ed1de0b13b72025-01-26T12:28:15ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-025-86746-wAssociation of TyG index with mortality at 28 days in sepsis patients in intensive care from MIMIC IV databaseHeping Xu0Jinyuan Xie1Yan Xia2Huan Niu3Hong Wang4Feng Zhan5Department of Emergency Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical UniversityDepartment of Emergency Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical UniversityDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Hainan Medical UniversityDepartment of Emergency Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical UniversityDepartment of Emergency Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical UniversityDepartment of Emergency Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical UniversityAbstract The relationship between the triglyceride‒glucose (TyG) index and the clinical prognosis of septic patients in intensive care units (ICUs) remains unclear. This study aimed to explore the correlation between the TyG index and 28-day all-cause mortality in septic patients. A retrospective observational cohort study was conducted, including 8955 septic patients from the MIMIC IV 2.2 database. The primary outcome was 28-day all-cause mortality. Multivariate logistic regression analysis and restricted cubic spline regression analysis were used to assess the relationship between the TyG index and 28-day all-cause mortality in septic patients. Subgroup analyses and sensitivity analyses were performed to further validate the robustness of the results. A total of 8955 septic patients were included, 5219 (58.3%) of whom were male, with a mean age of 66.3 (15.8) years and an average TyG index of 9.08 (0.70) and the number of deaths within 28 days was 1639 (18.3%). The RCS curve demonstrated a U-shaped relationship between the TyG index and 28-day all-cause mortality (nonlinear P value = 0.0003). The risk of 28-day all-cause mortality was negatively associated with the TyG index until it decreased to 9.03 (adjusted odds ratio [OR] 0.727, 95% confidence interval [CI] 0.577–0.915). However, when the TyG index exceeded 9.03, the odds ratio for 28-day all-cause mortality significantly increased (adjusted OR 1.185, 95% CI 1.001–1.404). These findings were consistent across subgroups and various sensitivity analyses. Our study revealed a nonlinear U-shaped relationship between the TyG index and 28-day all-cause mortality, with a critical point at a TyG index of 9.03. Our results suggest that the TyG index may be a novel and important factor for the short-term clinical prognosis of critically ill septic patients.https://doi.org/10.1038/s41598-025-86746-wTriglyceride-glucose indexSepsisAll-cause mortalityInsulin resistanceMIMIC-IV database |
| spellingShingle | Heping Xu Jinyuan Xie Yan Xia Huan Niu Hong Wang Feng Zhan Association of TyG index with mortality at 28 days in sepsis patients in intensive care from MIMIC IV database Scientific Reports Triglyceride-glucose index Sepsis All-cause mortality Insulin resistance MIMIC-IV database |
| title | Association of TyG index with mortality at 28 days in sepsis patients in intensive care from MIMIC IV database |
| title_full | Association of TyG index with mortality at 28 days in sepsis patients in intensive care from MIMIC IV database |
| title_fullStr | Association of TyG index with mortality at 28 days in sepsis patients in intensive care from MIMIC IV database |
| title_full_unstemmed | Association of TyG index with mortality at 28 days in sepsis patients in intensive care from MIMIC IV database |
| title_short | Association of TyG index with mortality at 28 days in sepsis patients in intensive care from MIMIC IV database |
| title_sort | association of tyg index with mortality at 28 days in sepsis patients in intensive care from mimic iv database |
| topic | Triglyceride-glucose index Sepsis All-cause mortality Insulin resistance MIMIC-IV database |
| url | https://doi.org/10.1038/s41598-025-86746-w |
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