Characteristics of serum bile acid profiles among individuals with metabolic dysfunction-associated steatotic liver disease
Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the predominant chronic liver condition globally. Bile acid (BA) metabolism contributes significantly to MASLD progression. In this multicenter clinical study, we aimed to characterize serum BA profiles i...
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2025-05-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-025-03903-1 |
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| author | Sheng Lyu Jiani Yang Xin Xin Qinmei Sun Beiyu Cai Xin Wang Ziming An Jian Sun Yiyang Hu Lei Shi Qin Feng Xiaojun Gou |
| author_facet | Sheng Lyu Jiani Yang Xin Xin Qinmei Sun Beiyu Cai Xin Wang Ziming An Jian Sun Yiyang Hu Lei Shi Qin Feng Xiaojun Gou |
| author_sort | Sheng Lyu |
| collection | DOAJ |
| description | Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the predominant chronic liver condition globally. Bile acid (BA) metabolism contributes significantly to MASLD progression. In this multicenter clinical study, we aimed to characterize serum BA profiles in patients with MASLD and identify specific alterations compared to healthy controls. Methods All MASLD cases were sourced from the gastroenterology outpatient departments of Shanghai Baoshan Hospital of Integrated Chinese and Western Medicine, Shanghai Baoshan District Songnan Community Health Service Center, and Lianyungang Oriental Hospital between June 2015 and December 2019. The data were analyzed using SPSS version 26.0, with a p-value of less than 0.05 considered significant. Results A total of 215 participants (35.3% women) with MASLD and 49 controls (44.9% women), aged 18–65 years, were included. MASLD patients showed higher levels of serum total BA (TBA), cholic acid (CA), chenodeoxycholic acid (CDCA), and ursodeoxycholic acid (UDCA) (p < 0.05, p < 0.01) when compared to controls. Furthermore, women patients with MASLD demonstrated notably higher levels of lithocholic acid (LCA), glycolithocholic acid (GLCA), and taurolithocholic acid (TLCA) than men patients with MASLD (p < 0.025, p < 0.01). Compared to women, men exhibited a higher proportion of primary to secondary BAs. Additionally, in men patients with MASLD, the serum concentrations of CA, CDCA, glycocholic acid (GCA), glycochenodeoxycholic acid (GCDCA), and taurochenodeoxycholic acid (TCDCA) exhibited significant negative correlations with ALT levels, while deoxycholic acid (DCA) and TLCA showed negative correlations with BMI. Conclusions Patients with MASLD exhibited notable variations in BA profiles, including sex-specific differences. This study provides corresponding evidence on the association between BAs and MASLD. Trial registration Chinese Clinical Trial Registry, NO: ChiCTR-OOC-15006157, registration date: March 25, 2015. |
| format | Article |
| id | doaj-art-2d9722dd983b4da59c4f988a28b31ece |
| institution | DOAJ |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-05-01 |
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| series | BMC Gastroenterology |
| spelling | doaj-art-2d9722dd983b4da59c4f988a28b31ece2025-08-20T03:09:19ZengBMCBMC Gastroenterology1471-230X2025-05-0125111110.1186/s12876-025-03903-1Characteristics of serum bile acid profiles among individuals with metabolic dysfunction-associated steatotic liver diseaseSheng Lyu0Jiani Yang1Xin Xin2Qinmei Sun3Beiyu Cai4Xin Wang5Ziming An6Jian Sun7Yiyang Hu8Lei Shi9Qin Feng10Xiaojun Gou11Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineInstitute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineInstitute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineInstitute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineInstitute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineInstitute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineInstitute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineClinical Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineInstitute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineClinical Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineInstitute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineBaoshan District Hospital of Integrated Traditional Chinese and Western Medicine of ShanghaiAbstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the predominant chronic liver condition globally. Bile acid (BA) metabolism contributes significantly to MASLD progression. In this multicenter clinical study, we aimed to characterize serum BA profiles in patients with MASLD and identify specific alterations compared to healthy controls. Methods All MASLD cases were sourced from the gastroenterology outpatient departments of Shanghai Baoshan Hospital of Integrated Chinese and Western Medicine, Shanghai Baoshan District Songnan Community Health Service Center, and Lianyungang Oriental Hospital between June 2015 and December 2019. The data were analyzed using SPSS version 26.0, with a p-value of less than 0.05 considered significant. Results A total of 215 participants (35.3% women) with MASLD and 49 controls (44.9% women), aged 18–65 years, were included. MASLD patients showed higher levels of serum total BA (TBA), cholic acid (CA), chenodeoxycholic acid (CDCA), and ursodeoxycholic acid (UDCA) (p < 0.05, p < 0.01) when compared to controls. Furthermore, women patients with MASLD demonstrated notably higher levels of lithocholic acid (LCA), glycolithocholic acid (GLCA), and taurolithocholic acid (TLCA) than men patients with MASLD (p < 0.025, p < 0.01). Compared to women, men exhibited a higher proportion of primary to secondary BAs. Additionally, in men patients with MASLD, the serum concentrations of CA, CDCA, glycocholic acid (GCA), glycochenodeoxycholic acid (GCDCA), and taurochenodeoxycholic acid (TCDCA) exhibited significant negative correlations with ALT levels, while deoxycholic acid (DCA) and TLCA showed negative correlations with BMI. Conclusions Patients with MASLD exhibited notable variations in BA profiles, including sex-specific differences. This study provides corresponding evidence on the association between BAs and MASLD. Trial registration Chinese Clinical Trial Registry, NO: ChiCTR-OOC-15006157, registration date: March 25, 2015.https://doi.org/10.1186/s12876-025-03903-1Metabolic dysfunction-associated steatotic liver diseaseBile acidSex |
| spellingShingle | Sheng Lyu Jiani Yang Xin Xin Qinmei Sun Beiyu Cai Xin Wang Ziming An Jian Sun Yiyang Hu Lei Shi Qin Feng Xiaojun Gou Characteristics of serum bile acid profiles among individuals with metabolic dysfunction-associated steatotic liver disease BMC Gastroenterology Metabolic dysfunction-associated steatotic liver disease Bile acid Sex |
| title | Characteristics of serum bile acid profiles among individuals with metabolic dysfunction-associated steatotic liver disease |
| title_full | Characteristics of serum bile acid profiles among individuals with metabolic dysfunction-associated steatotic liver disease |
| title_fullStr | Characteristics of serum bile acid profiles among individuals with metabolic dysfunction-associated steatotic liver disease |
| title_full_unstemmed | Characteristics of serum bile acid profiles among individuals with metabolic dysfunction-associated steatotic liver disease |
| title_short | Characteristics of serum bile acid profiles among individuals with metabolic dysfunction-associated steatotic liver disease |
| title_sort | characteristics of serum bile acid profiles among individuals with metabolic dysfunction associated steatotic liver disease |
| topic | Metabolic dysfunction-associated steatotic liver disease Bile acid Sex |
| url | https://doi.org/10.1186/s12876-025-03903-1 |
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