Simultaneous Occurrence of HER2 Mutations in EGFR Mutant NSCLC: Case Reports
HER2 mutation and amplification have been identified as distinct molecular targets in lung cancer with different therapeutic and prognostic values. The coexistence of HER2 and EGFR mutations is extremely rare, and therefore, no data exist on the best treatment in these cases.
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | JTO Clinical and Research Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666364324000894 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850138391586275328 |
|---|---|
| author | Blerina Resuli, MD Diego Kauffmann-Guerrero, MD Jürgen Behr, MD Amanda Tufman, MD |
| author_facet | Blerina Resuli, MD Diego Kauffmann-Guerrero, MD Jürgen Behr, MD Amanda Tufman, MD |
| author_sort | Blerina Resuli, MD |
| collection | DOAJ |
| description | HER2 mutation and amplification have been identified as distinct molecular targets in lung cancer with different therapeutic and prognostic values. The coexistence of HER2 and EGFR mutations is extremely rare, and therefore, no data exist on the best treatment in these cases. |
| format | Article |
| id | doaj-art-2d970efa183942f79af2ce5c962b4b3a |
| institution | OA Journals |
| issn | 2666-3643 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JTO Clinical and Research Reports |
| spelling | doaj-art-2d970efa183942f79af2ce5c962b4b3a2025-08-20T02:30:35ZengElsevierJTO Clinical and Research Reports2666-36432024-12-0151210071910.1016/j.jtocrr.2024.100719Simultaneous Occurrence of HER2 Mutations in EGFR Mutant NSCLC: Case ReportsBlerina Resuli, MD0Diego Kauffmann-Guerrero, MD1Jürgen Behr, MD2Amanda Tufman, MD3Department of Medicine V, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany; Comprehensive Pneumology Center Munich, German Center for Lung Research, Munich, Germany; Corresponding author. Address for correspondence: Blerina Resuli, MD, Department of Medicine V, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.Department of Medicine V, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany; Comprehensive Pneumology Center Munich, German Center for Lung Research, Munich, GermanyDepartment of Medicine V, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany; Comprehensive Pneumology Center Munich, German Center for Lung Research, Munich, GermanyDepartment of Medicine V, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany; Comprehensive Pneumology Center Munich, German Center for Lung Research, Munich, GermanyHER2 mutation and amplification have been identified as distinct molecular targets in lung cancer with different therapeutic and prognostic values. The coexistence of HER2 and EGFR mutations is extremely rare, and therefore, no data exist on the best treatment in these cases.http://www.sciencedirect.com/science/article/pii/S2666364324000894AfatinibCase reportEGFR mutationHER2 mutationsNon–small cell lung cancerOsimertinib |
| spellingShingle | Blerina Resuli, MD Diego Kauffmann-Guerrero, MD Jürgen Behr, MD Amanda Tufman, MD Simultaneous Occurrence of HER2 Mutations in EGFR Mutant NSCLC: Case Reports JTO Clinical and Research Reports Afatinib Case report EGFR mutation HER2 mutations Non–small cell lung cancer Osimertinib |
| title | Simultaneous Occurrence of HER2 Mutations in EGFR Mutant NSCLC: Case Reports |
| title_full | Simultaneous Occurrence of HER2 Mutations in EGFR Mutant NSCLC: Case Reports |
| title_fullStr | Simultaneous Occurrence of HER2 Mutations in EGFR Mutant NSCLC: Case Reports |
| title_full_unstemmed | Simultaneous Occurrence of HER2 Mutations in EGFR Mutant NSCLC: Case Reports |
| title_short | Simultaneous Occurrence of HER2 Mutations in EGFR Mutant NSCLC: Case Reports |
| title_sort | simultaneous occurrence of her2 mutations in egfr mutant nsclc case reports |
| topic | Afatinib Case report EGFR mutation HER2 mutations Non–small cell lung cancer Osimertinib |
| url | http://www.sciencedirect.com/science/article/pii/S2666364324000894 |
| work_keys_str_mv | AT blerinaresulimd simultaneousoccurrenceofher2mutationsinegfrmutantnsclccasereports AT diegokauffmannguerreromd simultaneousoccurrenceofher2mutationsinegfrmutantnsclccasereports AT jurgenbehrmd simultaneousoccurrenceofher2mutationsinegfrmutantnsclccasereports AT amandatufmanmd simultaneousoccurrenceofher2mutationsinegfrmutantnsclccasereports |