Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders
A dysfunction of cortical and limbic GABAergic circuits has been postulated to contribute to multiple neurodevelopmental disorders in humans, including schizophrenia, autism, and epilepsy. In the current paper, I summarize the characteristics that underlie the great diversity of cortical GABAergic i...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2011/649325 |
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| _version_ | 1849306723403169792 |
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| author | E. Rossignol |
| author_facet | E. Rossignol |
| author_sort | E. Rossignol |
| collection | DOAJ |
| description | A dysfunction of cortical and limbic GABAergic circuits has been postulated to contribute to multiple neurodevelopmental disorders in humans, including schizophrenia, autism, and epilepsy. In the current paper, I summarize the characteristics that underlie the great diversity of cortical GABAergic interneurons and explore how the multiple roles of these cells in developing and mature circuits might contribute to the aforementioned disorders. Furthermore, I review the tightly controlled genetic cascades that determine the fate of cortical interneurons and summarize how the dysfunction of genes important for the generation, specification, maturation, and function of cortical interneurons might contribute to these disorders. |
| format | Article |
| id | doaj-art-2d96660e489a4e538f795d7cc15c53d7 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-2d96660e489a4e538f795d7cc15c53d72025-08-20T03:55:00ZengWileyNeural Plasticity2090-59041687-54432011-01-01201110.1155/2011/649325649325Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental DisordersE. Rossignol0Department of Pediatrics, Neurology, Sainte-Justine Hospital and Research Center, 3175 Chemin de la Côte Sainte-Catherine, Montreal, QC, H3T 1C5, CanadaA dysfunction of cortical and limbic GABAergic circuits has been postulated to contribute to multiple neurodevelopmental disorders in humans, including schizophrenia, autism, and epilepsy. In the current paper, I summarize the characteristics that underlie the great diversity of cortical GABAergic interneurons and explore how the multiple roles of these cells in developing and mature circuits might contribute to the aforementioned disorders. Furthermore, I review the tightly controlled genetic cascades that determine the fate of cortical interneurons and summarize how the dysfunction of genes important for the generation, specification, maturation, and function of cortical interneurons might contribute to these disorders.http://dx.doi.org/10.1155/2011/649325 |
| spellingShingle | E. Rossignol Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders Neural Plasticity |
| title | Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders |
| title_full | Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders |
| title_fullStr | Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders |
| title_full_unstemmed | Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders |
| title_short | Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders |
| title_sort | genetics and function of neocortical gabaergic interneurons in neurodevelopmental disorders |
| url | http://dx.doi.org/10.1155/2011/649325 |
| work_keys_str_mv | AT erossignol geneticsandfunctionofneocorticalgabaergicinterneuronsinneurodevelopmentaldisorders |