Current Perspectives in NSAID-Induced Gastropathy
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most highly prescribed drugs in the world. Their analgesic, anti-inflammatory, and antipyretic actions may be beneficial; however, they are associated with severe side effects including gastrointestinal injury and peptic ulceration. Though severa...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/258209 |
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| author | Mau Sinha Lovely Gautam Prakash Kumar Shukla Punit Kaur Sujata Sharma Tej P. Singh |
| author_facet | Mau Sinha Lovely Gautam Prakash Kumar Shukla Punit Kaur Sujata Sharma Tej P. Singh |
| author_sort | Mau Sinha |
| collection | DOAJ |
| description | Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most highly prescribed drugs in the world. Their analgesic, anti-inflammatory, and antipyretic actions may be beneficial; however, they are associated with severe side effects including gastrointestinal injury and peptic ulceration. Though several approaches for limiting these side effects have been adopted, like the use of COX-2 specific drugs, comedication of acid suppressants like proton pump inhibitors and prostaglandin analogs, these alternatives have limitations in terms of efficacy and side effects. In this paper, the mechanism of action of NSAIDs and their critical gastrointestinal complications have been reviewed. This paper also provides the information on different preventive measures prescribed to minimize such adverse effects and analyses the new suggested strategies for development of novel drugs to maintain the anti-inflammatory functions of NSAIDs along with effective gastrointestinal protection. |
| format | Article |
| id | doaj-art-2d94d57c1220413c921f9128378cd288 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-2d94d57c1220413c921f9128378cd2882025-02-03T01:04:43ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/258209258209Current Perspectives in NSAID-Induced GastropathyMau Sinha0Lovely Gautam1Prakash Kumar Shukla2Punit Kaur3Sujata Sharma4Tej P. Singh5Department of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, IndiaDepartment of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, IndiaDepartment of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, IndiaDepartment of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, IndiaDepartment of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, IndiaDepartment of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, IndiaNonsteroidal anti-inflammatory drugs (NSAIDs) are the most highly prescribed drugs in the world. Their analgesic, anti-inflammatory, and antipyretic actions may be beneficial; however, they are associated with severe side effects including gastrointestinal injury and peptic ulceration. Though several approaches for limiting these side effects have been adopted, like the use of COX-2 specific drugs, comedication of acid suppressants like proton pump inhibitors and prostaglandin analogs, these alternatives have limitations in terms of efficacy and side effects. In this paper, the mechanism of action of NSAIDs and their critical gastrointestinal complications have been reviewed. This paper also provides the information on different preventive measures prescribed to minimize such adverse effects and analyses the new suggested strategies for development of novel drugs to maintain the anti-inflammatory functions of NSAIDs along with effective gastrointestinal protection.http://dx.doi.org/10.1155/2013/258209 |
| spellingShingle | Mau Sinha Lovely Gautam Prakash Kumar Shukla Punit Kaur Sujata Sharma Tej P. Singh Current Perspectives in NSAID-Induced Gastropathy Mediators of Inflammation |
| title | Current Perspectives in NSAID-Induced Gastropathy |
| title_full | Current Perspectives in NSAID-Induced Gastropathy |
| title_fullStr | Current Perspectives in NSAID-Induced Gastropathy |
| title_full_unstemmed | Current Perspectives in NSAID-Induced Gastropathy |
| title_short | Current Perspectives in NSAID-Induced Gastropathy |
| title_sort | current perspectives in nsaid induced gastropathy |
| url | http://dx.doi.org/10.1155/2013/258209 |
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