Etiopathogenesis of Nonalcoholic Steatohepatitis: Role of Obesity, Insulin Resistance and Mechanisms of Hepatotoxicity
Incidence of nonalcoholic fatty liver disease is increasing with an estimated prevalence of 20–30% in developed nations. This is leading to increased incidence of chronic liver disease, cirrhosis, and hepatocellular cancer. It is critical to understand the etiology and pathogenesis of any disease to...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2012/212865 |
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| _version_ | 1849306722653437952 |
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| author | Praveen Guturu Andrea Duchini |
| author_facet | Praveen Guturu Andrea Duchini |
| author_sort | Praveen Guturu |
| collection | DOAJ |
| description | Incidence of nonalcoholic fatty liver disease is increasing with an estimated prevalence of 20–30% in developed nations. This is leading to increased incidence of chronic liver disease, cirrhosis, and hepatocellular cancer. It is critical to understand the etiology and pathogenesis of any disease to create therapeutic targets and develop new treatments. In this paper we discuss the etiology and pathogenesis of nonalcoholic steatohepatitis with special focus on obesity, role of insulin resistance, and molecular mechanisms of hepatotoxicity. |
| format | Article |
| id | doaj-art-2d9395fdaea44f34a0c99685a8787a8f |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-2d9395fdaea44f34a0c99685a8787a8f2025-08-20T03:55:00ZengWileyInternational Journal of Hepatology2090-34482090-34562012-01-01201210.1155/2012/212865212865Etiopathogenesis of Nonalcoholic Steatohepatitis: Role of Obesity, Insulin Resistance and Mechanisms of HepatotoxicityPraveen Guturu0Andrea Duchini1Division of Gastroenterology and Hepatology, University of Texas Medical Branch (UTMB), 301 University Boulevard, Galveston, TX 77555, USADivision of Gastroenterology and Hepatology, University of Texas Medical Branch (UTMB), 301 University Boulevard, Galveston, TX 77555, USAIncidence of nonalcoholic fatty liver disease is increasing with an estimated prevalence of 20–30% in developed nations. This is leading to increased incidence of chronic liver disease, cirrhosis, and hepatocellular cancer. It is critical to understand the etiology and pathogenesis of any disease to create therapeutic targets and develop new treatments. In this paper we discuss the etiology and pathogenesis of nonalcoholic steatohepatitis with special focus on obesity, role of insulin resistance, and molecular mechanisms of hepatotoxicity.http://dx.doi.org/10.1155/2012/212865 |
| spellingShingle | Praveen Guturu Andrea Duchini Etiopathogenesis of Nonalcoholic Steatohepatitis: Role of Obesity, Insulin Resistance and Mechanisms of Hepatotoxicity International Journal of Hepatology |
| title | Etiopathogenesis of Nonalcoholic Steatohepatitis: Role of Obesity, Insulin Resistance and Mechanisms of Hepatotoxicity |
| title_full | Etiopathogenesis of Nonalcoholic Steatohepatitis: Role of Obesity, Insulin Resistance and Mechanisms of Hepatotoxicity |
| title_fullStr | Etiopathogenesis of Nonalcoholic Steatohepatitis: Role of Obesity, Insulin Resistance and Mechanisms of Hepatotoxicity |
| title_full_unstemmed | Etiopathogenesis of Nonalcoholic Steatohepatitis: Role of Obesity, Insulin Resistance and Mechanisms of Hepatotoxicity |
| title_short | Etiopathogenesis of Nonalcoholic Steatohepatitis: Role of Obesity, Insulin Resistance and Mechanisms of Hepatotoxicity |
| title_sort | etiopathogenesis of nonalcoholic steatohepatitis role of obesity insulin resistance and mechanisms of hepatotoxicity |
| url | http://dx.doi.org/10.1155/2012/212865 |
| work_keys_str_mv | AT praveenguturu etiopathogenesisofnonalcoholicsteatohepatitisroleofobesityinsulinresistanceandmechanismsofhepatotoxicity AT andreaduchini etiopathogenesisofnonalcoholicsteatohepatitisroleofobesityinsulinresistanceandmechanismsofhepatotoxicity |