Clinical and Pathophysiological Correlations in Acute Stroke, CT Visualized at Different Times
Two hundred twenty one patients aged 32-93 years with brain infarction, admitted to a Vascular Neurology Center in the first 3-48 hours (mean 6 hours) after the onset of the symptoms of stroke with computed tomography (CT) verified diagnosis were enrolled in the study. According to the timing of the...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
LLC "Publishing House OKI"
2020-05-01
|
| Series: | Антибиотики и Химиотерапия |
| Subjects: | |
| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/584 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850063416162516992 |
|---|---|
| author | S. A. Rumyantseva E. V. Silina N. A. Gomboeva V. A. Stupin YU. D. Vasiliev A. L. Kovalenko E. N. Kabaeva |
| author_facet | S. A. Rumyantseva E. V. Silina N. A. Gomboeva V. A. Stupin YU. D. Vasiliev A. L. Kovalenko E. N. Kabaeva |
| author_sort | S. A. Rumyantseva |
| collection | DOAJ |
| description | Two hundred twenty one patients aged 32-93 years with brain infarction, admitted to a Vascular Neurology Center in the first 3-48 hours (mean 6 hours) after the onset of the symptoms of stroke with computed tomography (CT) verified diagnosis were enrolled in the study. According to the timing of the CT-verification the patients were divided into 2 groups: «early» visualization (EV 50.2%) and «late» visualization (LV, 49.8%). In the EV group the lesion was visualized by CT on the admission (3-6 hours after the admission), in the LV group it was visualized only when CT was repeated 2-3 days after the admission. The patients in the LV group demonstrated increased severity of the underlying pathology, increased mortality and unfavourable functional outcomes correlating with the stroke lesion volume vs. the EV group. There was observed pathophysiological correlation of the blood enzymatic spectrum and acid-base balance parameters, explaining the late lesion visualization by delayed and more pronounced intracellular energy synthesis stabilization mechanisms failure in the aerobic and anaerobic glycolysis cycles. |
| format | Article |
| id | doaj-art-2d939384129d4fdbb22aa13a9a6d7a47 |
| institution | DOAJ |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-2d939384129d4fdbb22aa13a9a6d7a472025-08-20T02:49:36ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01601-22734583Clinical and Pathophysiological Correlations in Acute Stroke, CT Visualized at Different TimesS. A. Rumyantseva0E. V. Silina1N. A. Gomboeva2V. A. Stupin3YU. D. Vasiliev4A. L. Kovalenko5E. N. Kabaeva6N.I. Pirogov Russian National Research Medical UniversityI.M. Sechenov 1st Moscow State Medical UniversityI.M. Sechenov 1st Moscow State Medical UniversityN.I. Pirogov Russian National Research Medical UniversityO.M. Filatov Municipal Clinical Hospital No. 15, MoscowInstitute of Toxicology, Federal Medico-Biological Agency, St. PetersburgI.M. Sechenov 1st Moscow State Medical University O.M. Filatov Municipal Clinical Hospital No. 15, MoscowTwo hundred twenty one patients aged 32-93 years with brain infarction, admitted to a Vascular Neurology Center in the first 3-48 hours (mean 6 hours) after the onset of the symptoms of stroke with computed tomography (CT) verified diagnosis were enrolled in the study. According to the timing of the CT-verification the patients were divided into 2 groups: «early» visualization (EV 50.2%) and «late» visualization (LV, 49.8%). In the EV group the lesion was visualized by CT on the admission (3-6 hours after the admission), in the LV group it was visualized only when CT was repeated 2-3 days after the admission. The patients in the LV group demonstrated increased severity of the underlying pathology, increased mortality and unfavourable functional outcomes correlating with the stroke lesion volume vs. the EV group. There was observed pathophysiological correlation of the blood enzymatic spectrum and acid-base balance parameters, explaining the late lesion visualization by delayed and more pronounced intracellular energy synthesis stabilization mechanisms failure in the aerobic and anaerobic glycolysis cycles.https://www.antibiotics-chemotherapy.ru/jour/article/view/584strokecerebral infarctionoutcomecomputed tomographyvizualizationpenumbraenergosynthesisacid-base statuslactic acidosisglycolysis |
| spellingShingle | S. A. Rumyantseva E. V. Silina N. A. Gomboeva V. A. Stupin YU. D. Vasiliev A. L. Kovalenko E. N. Kabaeva Clinical and Pathophysiological Correlations in Acute Stroke, CT Visualized at Different Times Антибиотики и Химиотерапия stroke cerebral infarction outcome computed tomography vizualization penumbra energosynthesis acid-base status lactic acidosis glycolysis |
| title | Clinical and Pathophysiological Correlations in Acute Stroke, CT Visualized at Different Times |
| title_full | Clinical and Pathophysiological Correlations in Acute Stroke, CT Visualized at Different Times |
| title_fullStr | Clinical and Pathophysiological Correlations in Acute Stroke, CT Visualized at Different Times |
| title_full_unstemmed | Clinical and Pathophysiological Correlations in Acute Stroke, CT Visualized at Different Times |
| title_short | Clinical and Pathophysiological Correlations in Acute Stroke, CT Visualized at Different Times |
| title_sort | clinical and pathophysiological correlations in acute stroke ct visualized at different times |
| topic | stroke cerebral infarction outcome computed tomography vizualization penumbra energosynthesis acid-base status lactic acidosis glycolysis |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/584 |
| work_keys_str_mv | AT sarumyantseva clinicalandpathophysiologicalcorrelationsinacutestrokectvisualizedatdifferenttimes AT evsilina clinicalandpathophysiologicalcorrelationsinacutestrokectvisualizedatdifferenttimes AT nagomboeva clinicalandpathophysiologicalcorrelationsinacutestrokectvisualizedatdifferenttimes AT vastupin clinicalandpathophysiologicalcorrelationsinacutestrokectvisualizedatdifferenttimes AT yudvasiliev clinicalandpathophysiologicalcorrelationsinacutestrokectvisualizedatdifferenttimes AT alkovalenko clinicalandpathophysiologicalcorrelationsinacutestrokectvisualizedatdifferenttimes AT enkabaeva clinicalandpathophysiologicalcorrelationsinacutestrokectvisualizedatdifferenttimes |