A Grant Report: Examining the Efficacy of Remote Photobiomodulation Therapy in Adolescents with Major Depressive Disorder
Major depressive disorder (MDD) is a prevalent mental health condition affecting a significant portion of the population worldwide. This condition can impact individuals of all ages, including adolescents, leading to an impact on various aspects of their lives. Adolescence is a crucial phase of huma...
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MDPI AG
2024-09-01
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| Series: | Photonics |
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| Online Access: | https://www.mdpi.com/2304-6732/11/9/839 |
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| author | Adriano Alberti Willians Fernando Vieira David Richer Araujo Coelho Daniel Fernandes Martins |
| author_facet | Adriano Alberti Willians Fernando Vieira David Richer Araujo Coelho Daniel Fernandes Martins |
| author_sort | Adriano Alberti |
| collection | DOAJ |
| description | Major depressive disorder (MDD) is a prevalent mental health condition affecting a significant portion of the population worldwide. This condition can impact individuals of all ages, including adolescents, leading to an impact on various aspects of their lives. Adolescence is a crucial phase of human development, characterized by several neurobiological changes. The onset of MDD during this period can result in damage not only to teenagers but also might have long-lasting implications for their future as adults. Notably, the onset of MDD in adolescents is often associated with various biomarkers, such as increased levels of inflammatory cytokines (e.g., IL-6, TNF-α), oxidative stress markers, and alterations in neurotransmitter levels, indicating a complex interplay of biological factors. Therefore, early intervention is essential for addressing MDD during this phase. Photobiomodulation therapy (PBMT) emerges as an innovative and promising approach that utilizes light, especially in the near-infrared (NIR) and red spectra, to trigger biological and therapeutic effects. Notably, targeting the skull and abdomen with PBMT might explore the bidirectional communication between the intestinal system and the central nervous system in a remote and/or systemic way. In this context, we present the rationale and design of an ongoing study aiming to assess the efficacy of PBMT on depressive symptoms and biomarkers associated with oxidative stress and mitochondrial function in adolescents with MDD. |
| format | Article |
| id | doaj-art-2d926cbcfcce4692ba0469288b4f5cc4 |
| institution | OA Journals |
| issn | 2304-6732 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Photonics |
| spelling | doaj-art-2d926cbcfcce4692ba0469288b4f5cc42025-08-20T01:55:46ZengMDPI AGPhotonics2304-67322024-09-0111983910.3390/photonics11090839A Grant Report: Examining the Efficacy of Remote Photobiomodulation Therapy in Adolescents with Major Depressive DisorderAdriano Alberti0Willians Fernando Vieira1David Richer Araujo Coelho2Daniel Fernandes Martins3Experimental Neuroscience Laboratory (LaNEx), Graduate Program in Health Sciences, University of Southern Santa Catarina, Palhoça 88132-260, BrazilDepartment of Anatomy, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo 5508-000, BrazilHarvard T. H. Chan School of Public Health, Boston, MA 02115, USAExperimental Neuroscience Laboratory (LaNEx), Graduate Program in Health Sciences, University of Southern Santa Catarina, Palhoça 88132-260, BrazilMajor depressive disorder (MDD) is a prevalent mental health condition affecting a significant portion of the population worldwide. This condition can impact individuals of all ages, including adolescents, leading to an impact on various aspects of their lives. Adolescence is a crucial phase of human development, characterized by several neurobiological changes. The onset of MDD during this period can result in damage not only to teenagers but also might have long-lasting implications for their future as adults. Notably, the onset of MDD in adolescents is often associated with various biomarkers, such as increased levels of inflammatory cytokines (e.g., IL-6, TNF-α), oxidative stress markers, and alterations in neurotransmitter levels, indicating a complex interplay of biological factors. Therefore, early intervention is essential for addressing MDD during this phase. Photobiomodulation therapy (PBMT) emerges as an innovative and promising approach that utilizes light, especially in the near-infrared (NIR) and red spectra, to trigger biological and therapeutic effects. Notably, targeting the skull and abdomen with PBMT might explore the bidirectional communication between the intestinal system and the central nervous system in a remote and/or systemic way. In this context, we present the rationale and design of an ongoing study aiming to assess the efficacy of PBMT on depressive symptoms and biomarkers associated with oxidative stress and mitochondrial function in adolescents with MDD.https://www.mdpi.com/2304-6732/11/9/839major depressive disorderdepressionadolescencephotobiomodulation |
| spellingShingle | Adriano Alberti Willians Fernando Vieira David Richer Araujo Coelho Daniel Fernandes Martins A Grant Report: Examining the Efficacy of Remote Photobiomodulation Therapy in Adolescents with Major Depressive Disorder Photonics major depressive disorder depression adolescence photobiomodulation |
| title | A Grant Report: Examining the Efficacy of Remote Photobiomodulation Therapy in Adolescents with Major Depressive Disorder |
| title_full | A Grant Report: Examining the Efficacy of Remote Photobiomodulation Therapy in Adolescents with Major Depressive Disorder |
| title_fullStr | A Grant Report: Examining the Efficacy of Remote Photobiomodulation Therapy in Adolescents with Major Depressive Disorder |
| title_full_unstemmed | A Grant Report: Examining the Efficacy of Remote Photobiomodulation Therapy in Adolescents with Major Depressive Disorder |
| title_short | A Grant Report: Examining the Efficacy of Remote Photobiomodulation Therapy in Adolescents with Major Depressive Disorder |
| title_sort | grant report examining the efficacy of remote photobiomodulation therapy in adolescents with major depressive disorder |
| topic | major depressive disorder depression adolescence photobiomodulation |
| url | https://www.mdpi.com/2304-6732/11/9/839 |
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