The Utility of Maternal Adiponectin and Triglyceride-Glycemic Index for Gestational Diabetes Mellitus Screening: A Cross-Sectional Study
Background: Gestational diabetes mellitus (GDM) is one of the most prominent diseases seen in pregnancy that adversely affects materno-fetal welfare. It is usually screened by an oral glucose tolerance test (GTT), which has some limitations. Adiponectin and triglyceride-glycemic (...
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| Format: | Article |
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IMR Press
2024-12-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/51/12/10.31083/j.ceog5112262 |
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| author | H.A.G. Al-Rawi Wassan Nori Dina Akeel Salman Abdulkareem H. Issa Wisam Akram |
| author_facet | H.A.G. Al-Rawi Wassan Nori Dina Akeel Salman Abdulkareem H. Issa Wisam Akram |
| author_sort | H.A.G. Al-Rawi |
| collection | DOAJ |
| description | Background: Gestational diabetes mellitus (GDM) is one of the most prominent diseases seen in pregnancy that adversely affects materno-fetal welfare. It is usually screened by an oral glucose tolerance test (GTT), which has some limitations. Adiponectin and triglyceride-glycemic (TyG) index were two biomarkers examined in the GDM context with inconclusive effectiveness. This study aimed to examine both markers' performance in screening for GDM among Iraqi women. Methods: An observational cross-sectional study recruited gestational age and body mass index (BMI) matched pregnant at 26–28 weeks into two groups: healthy controls (n = 44/88) and GDM cases (n = 44/88). Participants' demographics, biochemical [FBS (fasting blood sugar), 2hr_GTT (2-hour glucose tolerance test), HDL (high-density lipoprotein), LDL (low-density lipoprotein), total cholesterol, TG (triglyceride), and TyG index], and hormonal (adiponectin) were recorded. Results: Serum adiponectin was significantly higher among healthy pregnant (8.44 ± 1.12 ng/mL vs. 5.28 ± 0.89 ng/mL); p < 0.0001. In contrast, the TyG index was significantly higher among GDM cases (4.02 ± 0.04 vs. 3.96 ± 0.02; p < 0.0001). Adiponectin showed strong inverse links with FBS, 2hr_GTT with r = (–0.76, –0.80); p < 0.0001, respectively. TyG index was moderately, inversely, and significantly linked to serum adiponectin as r = –0.58; p < 0.0001. Adiponectin and TyG index reliably predicted GDM with a high area under the curve of 0.83 vs. 0.88; p < 0.001, respectively. Conclusions: Both biomarkers correlated well to GDM parameters and showed high sensitivity and specificity in screening for GDM. Their efficiency, easy integrations in practice, and promising therapeutic application suggested by researchers warrant further studies. |
| format | Article |
| id | doaj-art-2d92126073204d4aa7dfc3df2219986c |
| institution | OA Journals |
| issn | 0390-6663 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-2d92126073204d4aa7dfc3df2219986c2025-08-20T02:01:47ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632024-12-01511226210.31083/j.ceog5112262S0390-6663(24)02506-5The Utility of Maternal Adiponectin and Triglyceride-Glycemic Index for Gestational Diabetes Mellitus Screening: A Cross-Sectional StudyH.A.G. Al-Rawi0Wassan Nori1Dina Akeel Salman2Abdulkareem H. Issa3Wisam Akram4College of Medicine/Department of Obstetrics and Gynecology, Mustansiriyah University, 10052 Baghdad, IraqCollege of Medicine/Department of Obstetrics and Gynecology, Mustansiriyah University, 10052 Baghdad, IraqCollege of Medicine/Department of Obstetrics and Gynecology, Mustansiriyah University, 10052 Baghdad, IraqCollege of Medicine/Chemistry and Biochemistry Department, Mustansiriyah University, 10052 Baghdad, IraqCollege of Medicine/Department of Obstetrics and Gynecology, Mustansiriyah University, 10052 Baghdad, IraqBackground: Gestational diabetes mellitus (GDM) is one of the most prominent diseases seen in pregnancy that adversely affects materno-fetal welfare. It is usually screened by an oral glucose tolerance test (GTT), which has some limitations. Adiponectin and triglyceride-glycemic (TyG) index were two biomarkers examined in the GDM context with inconclusive effectiveness. This study aimed to examine both markers' performance in screening for GDM among Iraqi women. Methods: An observational cross-sectional study recruited gestational age and body mass index (BMI) matched pregnant at 26–28 weeks into two groups: healthy controls (n = 44/88) and GDM cases (n = 44/88). Participants' demographics, biochemical [FBS (fasting blood sugar), 2hr_GTT (2-hour glucose tolerance test), HDL (high-density lipoprotein), LDL (low-density lipoprotein), total cholesterol, TG (triglyceride), and TyG index], and hormonal (adiponectin) were recorded. Results: Serum adiponectin was significantly higher among healthy pregnant (8.44 ± 1.12 ng/mL vs. 5.28 ± 0.89 ng/mL); p < 0.0001. In contrast, the TyG index was significantly higher among GDM cases (4.02 ± 0.04 vs. 3.96 ± 0.02; p < 0.0001). Adiponectin showed strong inverse links with FBS, 2hr_GTT with r = (–0.76, –0.80); p < 0.0001, respectively. TyG index was moderately, inversely, and significantly linked to serum adiponectin as r = –0.58; p < 0.0001. Adiponectin and TyG index reliably predicted GDM with a high area under the curve of 0.83 vs. 0.88; p < 0.001, respectively. Conclusions: Both biomarkers correlated well to GDM parameters and showed high sensitivity and specificity in screening for GDM. Their efficiency, easy integrations in practice, and promising therapeutic application suggested by researchers warrant further studies.https://www.imrpress.com/journal/CEOG/51/12/10.31083/j.ceog5112262adiponectingestational diabetes mellitusscreeningtriglyceride-glycemic index |
| spellingShingle | H.A.G. Al-Rawi Wassan Nori Dina Akeel Salman Abdulkareem H. Issa Wisam Akram The Utility of Maternal Adiponectin and Triglyceride-Glycemic Index for Gestational Diabetes Mellitus Screening: A Cross-Sectional Study Clinical and Experimental Obstetrics & Gynecology adiponectin gestational diabetes mellitus screening triglyceride-glycemic index |
| title | The Utility of Maternal Adiponectin and Triglyceride-Glycemic Index for Gestational Diabetes Mellitus Screening: A Cross-Sectional Study |
| title_full | The Utility of Maternal Adiponectin and Triglyceride-Glycemic Index for Gestational Diabetes Mellitus Screening: A Cross-Sectional Study |
| title_fullStr | The Utility of Maternal Adiponectin and Triglyceride-Glycemic Index for Gestational Diabetes Mellitus Screening: A Cross-Sectional Study |
| title_full_unstemmed | The Utility of Maternal Adiponectin and Triglyceride-Glycemic Index for Gestational Diabetes Mellitus Screening: A Cross-Sectional Study |
| title_short | The Utility of Maternal Adiponectin and Triglyceride-Glycemic Index for Gestational Diabetes Mellitus Screening: A Cross-Sectional Study |
| title_sort | utility of maternal adiponectin and triglyceride glycemic index for gestational diabetes mellitus screening a cross sectional study |
| topic | adiponectin gestational diabetes mellitus screening triglyceride-glycemic index |
| url | https://www.imrpress.com/journal/CEOG/51/12/10.31083/j.ceog5112262 |
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