Potential therapeutic implications of miRNAs in osteosarcoma chemotherapy
Osteosarcoma is the most common primary bone cancer in young adults and adolescents. Drug resistance is the main cause leading to therapeutical failure. The mechanisms of drug resistance of osteosarcoma have not been fully understood. Notably, recent researches associate microRNA with drug resistanc...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-09-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317705762 |
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| _version_ | 1849416499468435456 |
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| author | Dan Chen Ding Liu Zhiwei Chen |
| author_facet | Dan Chen Ding Liu Zhiwei Chen |
| author_sort | Dan Chen |
| collection | DOAJ |
| description | Osteosarcoma is the most common primary bone cancer in young adults and adolescents. Drug resistance is the main cause leading to therapeutical failure. The mechanisms of drug resistance of osteosarcoma have not been fully understood. Notably, recent researches associate microRNA with drug resistance in osteosarcoma cells, raising the awareness that targeting microRNAs may help in chemotherapy success. In this review, we summarize the mechanisms linking microRNAs to drug resistance and ongoing researches on microRNAs in drug response to osteosarcoma. In addition, the therapeutic potential of microRNAs in chemotherapy will also be discussed. |
| format | Article |
| id | doaj-art-2d8ce337e6e74837b645e0d34b076ece |
| institution | Kabale University |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-2d8ce337e6e74837b645e0d34b076ece2025-08-20T03:33:10ZengSAGE PublishingTumor Biology1423-03802017-09-013910.1177/1010428317705762Potential therapeutic implications of miRNAs in osteosarcoma chemotherapyDan ChenDing LiuZhiwei ChenOsteosarcoma is the most common primary bone cancer in young adults and adolescents. Drug resistance is the main cause leading to therapeutical failure. The mechanisms of drug resistance of osteosarcoma have not been fully understood. Notably, recent researches associate microRNA with drug resistance in osteosarcoma cells, raising the awareness that targeting microRNAs may help in chemotherapy success. In this review, we summarize the mechanisms linking microRNAs to drug resistance and ongoing researches on microRNAs in drug response to osteosarcoma. In addition, the therapeutic potential of microRNAs in chemotherapy will also be discussed.https://doi.org/10.1177/1010428317705762 |
| spellingShingle | Dan Chen Ding Liu Zhiwei Chen Potential therapeutic implications of miRNAs in osteosarcoma chemotherapy Tumor Biology |
| title | Potential therapeutic implications of miRNAs in osteosarcoma chemotherapy |
| title_full | Potential therapeutic implications of miRNAs in osteosarcoma chemotherapy |
| title_fullStr | Potential therapeutic implications of miRNAs in osteosarcoma chemotherapy |
| title_full_unstemmed | Potential therapeutic implications of miRNAs in osteosarcoma chemotherapy |
| title_short | Potential therapeutic implications of miRNAs in osteosarcoma chemotherapy |
| title_sort | potential therapeutic implications of mirnas in osteosarcoma chemotherapy |
| url | https://doi.org/10.1177/1010428317705762 |
| work_keys_str_mv | AT danchen potentialtherapeuticimplicationsofmirnasinosteosarcomachemotherapy AT dingliu potentialtherapeuticimplicationsofmirnasinosteosarcomachemotherapy AT zhiweichen potentialtherapeuticimplicationsofmirnasinosteosarcomachemotherapy |