Histoplasmosis Presenting as Granulomatous Hepatitis: Case Report and Review of the Literature
Background. Histoplasma capsulatum is the most common endemic mycosis in the United States and is a frequent cause of opportunistic infection in immunodeficient hosts. Histoplasmosis is most often self-limiting and goes unrecognized in the immunocompetent population but can progress to disseminated...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/879535 |
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| author | Nancy A. Rihana Manasa Kandula Ana Velez Kumud Dahal Edward B. O’Neill |
| author_facet | Nancy A. Rihana Manasa Kandula Ana Velez Kumud Dahal Edward B. O’Neill |
| author_sort | Nancy A. Rihana |
| collection | DOAJ |
| description | Background. Histoplasma capsulatum is the most common endemic mycosis in the United States and is a frequent cause of opportunistic infection in immunodeficient hosts. Histoplasmosis is most often self-limiting and goes unrecognized in the immunocompetent population but can progress to disseminated histoplasmosis in patients with an impaired immune system. Liver involvement as a part of disseminated histoplasmosis which usually originates in the lung is well known. However, extrapulmonary hepatic histoplasmosis as a primary manifestation is extremely rare. Case Presentation. We report a rare case of histoplasmosis that presented as persistent fever and abnormal liver function tests in a 66-year-old female with rheumatoid arthritis, receiving infliximab. Conclusion. Emphasizing histoplasmosis as a major cause of acute granulomatous hepatitis and fever of unknown origin in cell mediated immunodeficient population, this case highlights the need for high index of suspicion and the importance of prompt diagnosis since any delay of treatment can be life threatening in this population. |
| format | Article |
| id | doaj-art-2d8cd0cce5714e418796ea596a7e01b6 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-2d8cd0cce5714e418796ea596a7e01b62025-02-03T01:29:56ZengWileyCase Reports in Medicine1687-96271687-96352014-01-01201410.1155/2014/879535879535Histoplasmosis Presenting as Granulomatous Hepatitis: Case Report and Review of the LiteratureNancy A. Rihana0Manasa Kandula1Ana Velez2Kumud Dahal3Edward B. O’Neill4Department of Infectious Diseases, University of South Florida, 1 Tampa General Circle G323, Tampa, FL 33606, USAUniversity of South Florida, Tampa, FL 33606, USADepartment of Infectious Diseases, University of South Florida, Tampa, FL 33606, USADepartment of Infectious Diseases, University of Illinois, One Illini Drive, Peoria, IL 61605-2576, USADepartment of Pathology, Tampa General Hospital, Tampa, FL 33606, USABackground. Histoplasma capsulatum is the most common endemic mycosis in the United States and is a frequent cause of opportunistic infection in immunodeficient hosts. Histoplasmosis is most often self-limiting and goes unrecognized in the immunocompetent population but can progress to disseminated histoplasmosis in patients with an impaired immune system. Liver involvement as a part of disseminated histoplasmosis which usually originates in the lung is well known. However, extrapulmonary hepatic histoplasmosis as a primary manifestation is extremely rare. Case Presentation. We report a rare case of histoplasmosis that presented as persistent fever and abnormal liver function tests in a 66-year-old female with rheumatoid arthritis, receiving infliximab. Conclusion. Emphasizing histoplasmosis as a major cause of acute granulomatous hepatitis and fever of unknown origin in cell mediated immunodeficient population, this case highlights the need for high index of suspicion and the importance of prompt diagnosis since any delay of treatment can be life threatening in this population.http://dx.doi.org/10.1155/2014/879535 |
| spellingShingle | Nancy A. Rihana Manasa Kandula Ana Velez Kumud Dahal Edward B. O’Neill Histoplasmosis Presenting as Granulomatous Hepatitis: Case Report and Review of the Literature Case Reports in Medicine |
| title | Histoplasmosis Presenting as Granulomatous Hepatitis: Case Report and Review of the Literature |
| title_full | Histoplasmosis Presenting as Granulomatous Hepatitis: Case Report and Review of the Literature |
| title_fullStr | Histoplasmosis Presenting as Granulomatous Hepatitis: Case Report and Review of the Literature |
| title_full_unstemmed | Histoplasmosis Presenting as Granulomatous Hepatitis: Case Report and Review of the Literature |
| title_short | Histoplasmosis Presenting as Granulomatous Hepatitis: Case Report and Review of the Literature |
| title_sort | histoplasmosis presenting as granulomatous hepatitis case report and review of the literature |
| url | http://dx.doi.org/10.1155/2014/879535 |
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