Prognostic analysis of early-onset and late-onset nasopharyngeal carcinoma: a retrospective study
Abstract Purpose There are few studies on early-onset and late-onset nasopharyngeal cancer (EONPC and LONPC, defined as cancers in those aged < 50 and ≥ 50 years, respectively). This study aimed to determine the clinical and survival characteristics of patients with NPC in these two age groups. M...
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Springer
2024-11-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-024-01594-w |
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| author | Pian Li Zhen Meng Dong Yang Tianyu Wu Yating Qin Xinghua Chen Yaya Wang Chuangjie Cao Min Kang |
| author_facet | Pian Li Zhen Meng Dong Yang Tianyu Wu Yating Qin Xinghua Chen Yaya Wang Chuangjie Cao Min Kang |
| author_sort | Pian Li |
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| description | Abstract Purpose There are few studies on early-onset and late-onset nasopharyngeal cancer (EONPC and LONPC, defined as cancers in those aged < 50 and ≥ 50 years, respectively). This study aimed to determine the clinical and survival characteristics of patients with NPC in these two age groups. Methods This study involved patients diagnosed with NPC between 2000 and 2018, as per the Surveillance, Epidemiology, and End Results (SEER) database, and in our institution from 2014 to 2017. The clinicopathological characteristics, treatment modalities, and survival outcomes of patients with EONPC and LONPC were analyzed and compared. Results A total of 2943 patients from the SEER database and 833 domestic patients from our center were enrolled in the study. The EONPC group showed a better prognosis than LONPC (p < 0.001), despite a worse staging of regional lymph node metastasis (p < 0.001). Similar results were validated at our center; further, patients with EONPC presented more EBV-DNA positive rates (58% vs. 36.8%, p < 0.001) than those with LONPC. Further, the EONPC group had a superior overall survival (OS) (p = 0.017) and cancer-specific survival (CSS) (p = 0.004) compared to that of the LONPC patients. Univariate and multivariate Cox regression analyses revealed EONPC to be independently associated with a higher five-year OS. Conclusions Though the EONPC group presented with more advanced clinical stages and lymph node metastasis, they showed better survival than the LONPC group. Age ≤ 50 years was an independent prognostic factor for survival outcomes in patients with NPC. Further studies on EONPC are warranted to achieve a better individualized therapeutic regimen. |
| format | Article |
| id | doaj-art-2d8ca4e097184f74a2f6f6457875e94c |
| institution | OA Journals |
| issn | 2730-6011 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-2d8ca4e097184f74a2f6f6457875e94c2025-08-20T02:33:05ZengSpringerDiscover Oncology2730-60112024-11-0115111610.1007/s12672-024-01594-wPrognostic analysis of early-onset and late-onset nasopharyngeal carcinoma: a retrospective studyPian Li0Zhen Meng1Dong Yang2Tianyu Wu3Yating Qin4Xinghua Chen5Yaya Wang6Chuangjie Cao7Min Kang8Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Tumor Radiation Therapy Clinical Medical Research CenterDepartment of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Tumor Radiation Therapy Clinical Medical Research CenterDepartment of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Tumor Radiation Therapy Clinical Medical Research CenterDepartment of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Tumor Radiation Therapy Clinical Medical Research CenterDepartment of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Tumor Radiation Therapy Clinical Medical Research CenterDepartment of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Tumor Radiation Therapy Clinical Medical Research CenterDepartment of Otolaryngology, The First Affiliated Hospital of Hengyang Medical School, University of South ChinaThe First Affiliated Hospital, Department of Pathology, Hengyang Medical School, University of South ChinaDepartment of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Tumor Radiation Therapy Clinical Medical Research CenterAbstract Purpose There are few studies on early-onset and late-onset nasopharyngeal cancer (EONPC and LONPC, defined as cancers in those aged < 50 and ≥ 50 years, respectively). This study aimed to determine the clinical and survival characteristics of patients with NPC in these two age groups. Methods This study involved patients diagnosed with NPC between 2000 and 2018, as per the Surveillance, Epidemiology, and End Results (SEER) database, and in our institution from 2014 to 2017. The clinicopathological characteristics, treatment modalities, and survival outcomes of patients with EONPC and LONPC were analyzed and compared. Results A total of 2943 patients from the SEER database and 833 domestic patients from our center were enrolled in the study. The EONPC group showed a better prognosis than LONPC (p < 0.001), despite a worse staging of regional lymph node metastasis (p < 0.001). Similar results were validated at our center; further, patients with EONPC presented more EBV-DNA positive rates (58% vs. 36.8%, p < 0.001) than those with LONPC. Further, the EONPC group had a superior overall survival (OS) (p = 0.017) and cancer-specific survival (CSS) (p = 0.004) compared to that of the LONPC patients. Univariate and multivariate Cox regression analyses revealed EONPC to be independently associated with a higher five-year OS. Conclusions Though the EONPC group presented with more advanced clinical stages and lymph node metastasis, they showed better survival than the LONPC group. Age ≤ 50 years was an independent prognostic factor for survival outcomes in patients with NPC. Further studies on EONPC are warranted to achieve a better individualized therapeutic regimen.https://doi.org/10.1007/s12672-024-01594-wClinical featuresSurvivalEarly-onset nasopharyngeal carcinomaLate-onset nasopharyngeal carcinomaRetrospective analysis |
| spellingShingle | Pian Li Zhen Meng Dong Yang Tianyu Wu Yating Qin Xinghua Chen Yaya Wang Chuangjie Cao Min Kang Prognostic analysis of early-onset and late-onset nasopharyngeal carcinoma: a retrospective study Discover Oncology Clinical features Survival Early-onset nasopharyngeal carcinoma Late-onset nasopharyngeal carcinoma Retrospective analysis |
| title | Prognostic analysis of early-onset and late-onset nasopharyngeal carcinoma: a retrospective study |
| title_full | Prognostic analysis of early-onset and late-onset nasopharyngeal carcinoma: a retrospective study |
| title_fullStr | Prognostic analysis of early-onset and late-onset nasopharyngeal carcinoma: a retrospective study |
| title_full_unstemmed | Prognostic analysis of early-onset and late-onset nasopharyngeal carcinoma: a retrospective study |
| title_short | Prognostic analysis of early-onset and late-onset nasopharyngeal carcinoma: a retrospective study |
| title_sort | prognostic analysis of early onset and late onset nasopharyngeal carcinoma a retrospective study |
| topic | Clinical features Survival Early-onset nasopharyngeal carcinoma Late-onset nasopharyngeal carcinoma Retrospective analysis |
| url | https://doi.org/10.1007/s12672-024-01594-w |
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