Multi-omics investigation of metabolic dysregulation in depression: integrating metabolomics, weighted gene co-expression network analysis, and mendelian randomization

Multi-omics investigation of metabolic dysregulation in depression: integrating metabolomics, weighted gene co-expression network analysis, and mendelian randomization

BackgroundThe etiology of depressive disorder, the leading cause of global mental disability, is characterized by systemic metabolic dysregulation. However, the causal metabolites and their mechanistic networks remain elusive.MethodsWe combined untargeted LC/GC-MS metabolomics (N=98 Chinese elderly)...

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Bibliographic Details
Main Authors: Wu Qianhao, Zhang Jinwen, Miao Jingjie, Chen Xiaoyu, Zhao Yangfei, Yao Wenxiu, Jiang Xu, Wang Xiaojun, Han Peipei, Guo Qi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Psychiatry
Subjects:
depression
metabolic diseases
untargeted metabolomics
Mendelian randomization
community-dwelling elderly
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1627020/full
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