Targeting pathogenic fibroblast-like synoviocyte subsets in rheumatoid arthritis
Abstract Fibroblast-like synoviocytes (FLSs) play a central role in RA pathogenesis and are the main cellular component in the inflamed synovium of patients with rheumatoid arthritis (RA). FLSs are emerging as promising new therapeutic targets in RA. However, fibroblasts perform many essential funct...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-05-01
|
| Series: | Arthritis Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13075-024-03343-4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850255839674236928 |
|---|---|
| author | Hongyan Qian Chaoqiong Deng Shiju Chen Xinwei Zhang Yan He Jingying Lan Aodi Wang Guixiu Shi Yuan Liu |
| author_facet | Hongyan Qian Chaoqiong Deng Shiju Chen Xinwei Zhang Yan He Jingying Lan Aodi Wang Guixiu Shi Yuan Liu |
| author_sort | Hongyan Qian |
| collection | DOAJ |
| description | Abstract Fibroblast-like synoviocytes (FLSs) play a central role in RA pathogenesis and are the main cellular component in the inflamed synovium of patients with rheumatoid arthritis (RA). FLSs are emerging as promising new therapeutic targets in RA. However, fibroblasts perform many essential functions that are required for sustaining tissue homeostasis. Direct targeting of general fibroblast markers on FLSs is challenging because fibroblasts in other tissues might be altered and side effects such as reduced wound healing or fibrosis can occur. To date, no FLS-specific targeted therapies have been applied in the clinical management of RA. With the help of high-throughput technologies such as scRNA-seq in recent years, several specific pathogenic FLS subsets in RA have been identified. Understanding the characteristics of these pathogenic FLS clusters and the mechanisms that drive their differentiation can provide new insights into the development of novel FLS-targeting strategies for RA. Here, we discuss the pathogenic FLS subsets in RA that have been elucidated in recent years and potential strategies for targeting pathogenic FLSs. |
| format | Article |
| id | doaj-art-2d84afc23e65472eb712edf206e496aa |
| institution | OA Journals |
| issn | 1478-6362 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthritis Research & Therapy |
| spelling | doaj-art-2d84afc23e65472eb712edf206e496aa2025-08-20T01:56:46ZengBMCArthritis Research & Therapy1478-63622024-05-0126111510.1186/s13075-024-03343-4Targeting pathogenic fibroblast-like synoviocyte subsets in rheumatoid arthritisHongyan Qian0Chaoqiong Deng1Shiju Chen2Xinwei Zhang3Yan He4Jingying Lan5Aodi Wang6Guixiu Shi7Yuan Liu8Department of Rheumatology and Clinical Immunology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Rheumatology and Clinical Immunology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Rheumatology and Clinical Immunology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Rheumatology and Clinical Immunology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Rheumatology and Clinical Immunology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Rheumatology and Clinical Immunology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Rheumatology and Clinical Immunology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Rheumatology and Clinical Immunology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Rheumatology and Clinical Immunology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityAbstract Fibroblast-like synoviocytes (FLSs) play a central role in RA pathogenesis and are the main cellular component in the inflamed synovium of patients with rheumatoid arthritis (RA). FLSs are emerging as promising new therapeutic targets in RA. However, fibroblasts perform many essential functions that are required for sustaining tissue homeostasis. Direct targeting of general fibroblast markers on FLSs is challenging because fibroblasts in other tissues might be altered and side effects such as reduced wound healing or fibrosis can occur. To date, no FLS-specific targeted therapies have been applied in the clinical management of RA. With the help of high-throughput technologies such as scRNA-seq in recent years, several specific pathogenic FLS subsets in RA have been identified. Understanding the characteristics of these pathogenic FLS clusters and the mechanisms that drive their differentiation can provide new insights into the development of novel FLS-targeting strategies for RA. Here, we discuss the pathogenic FLS subsets in RA that have been elucidated in recent years and potential strategies for targeting pathogenic FLSs.https://doi.org/10.1186/s13075-024-03343-4Fibroblast-like synoviocytesRheumatoid arthritisInflammationImmune homeostasisTherapeutic target |
| spellingShingle | Hongyan Qian Chaoqiong Deng Shiju Chen Xinwei Zhang Yan He Jingying Lan Aodi Wang Guixiu Shi Yuan Liu Targeting pathogenic fibroblast-like synoviocyte subsets in rheumatoid arthritis Arthritis Research & Therapy Fibroblast-like synoviocytes Rheumatoid arthritis Inflammation Immune homeostasis Therapeutic target |
| title | Targeting pathogenic fibroblast-like synoviocyte subsets in rheumatoid arthritis |
| title_full | Targeting pathogenic fibroblast-like synoviocyte subsets in rheumatoid arthritis |
| title_fullStr | Targeting pathogenic fibroblast-like synoviocyte subsets in rheumatoid arthritis |
| title_full_unstemmed | Targeting pathogenic fibroblast-like synoviocyte subsets in rheumatoid arthritis |
| title_short | Targeting pathogenic fibroblast-like synoviocyte subsets in rheumatoid arthritis |
| title_sort | targeting pathogenic fibroblast like synoviocyte subsets in rheumatoid arthritis |
| topic | Fibroblast-like synoviocytes Rheumatoid arthritis Inflammation Immune homeostasis Therapeutic target |
| url | https://doi.org/10.1186/s13075-024-03343-4 |
| work_keys_str_mv | AT hongyanqian targetingpathogenicfibroblastlikesynoviocytesubsetsinrheumatoidarthritis AT chaoqiongdeng targetingpathogenicfibroblastlikesynoviocytesubsetsinrheumatoidarthritis AT shijuchen targetingpathogenicfibroblastlikesynoviocytesubsetsinrheumatoidarthritis AT xinweizhang targetingpathogenicfibroblastlikesynoviocytesubsetsinrheumatoidarthritis AT yanhe targetingpathogenicfibroblastlikesynoviocytesubsetsinrheumatoidarthritis AT jingyinglan targetingpathogenicfibroblastlikesynoviocytesubsetsinrheumatoidarthritis AT aodiwang targetingpathogenicfibroblastlikesynoviocytesubsetsinrheumatoidarthritis AT guixiushi targetingpathogenicfibroblastlikesynoviocytesubsetsinrheumatoidarthritis AT yuanliu targetingpathogenicfibroblastlikesynoviocytesubsetsinrheumatoidarthritis |