Metabolic Syndrome in Patients with Depression: A Cross-sectional Comparative Study
Background: Depression is a leading cause of disability worldwide and is also known to be comorbid with a number of medical and psychiatric illnesses. Metabolic syndrome (MS) that is now emerging as a common lifestyle illness is found to be twofold greater in patients with depression. Often, antidep...
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Jaypee Brothers Medical Publisher
2023-02-01
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| Series: | Indian Journal of Private Psychiatry |
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| Online Access: | https://www.ijiapp.com/doi/IJPP/pdf/10.5005/jp-journals-10067-0129 |
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| author | Ajay Prakash Sourabh S Prashanth Nagabhushan Rudra Shankar Kumar Shalu Elizabeth Abraham |
| author_facet | Ajay Prakash Sourabh S Prashanth Nagabhushan Rudra Shankar Kumar Shalu Elizabeth Abraham |
| author_sort | Ajay Prakash |
| collection | DOAJ |
| description | Background: Depression is a leading cause of disability worldwide and is also known to be comorbid with a number of medical and psychiatric illnesses. Metabolic syndrome (MS) that is now emerging as a common lifestyle illness is found to be twofold greater in patients with depression. Often, antidepressants have been considered to be the reason for this possible link, however, research from the West suggests that a direct link is plausible. There is a scarcity of literature supporting these data from the East. In this study, we have attempted to assess the prevalence of MS in depressive patients, and to determine the probable risk factors contributing to the association.
Materials and methods: Sixty consecutive patients that fulfilled the inclusion criteria were recruited from a tertiary care center in India. Sociodemographic and clinical data were obtained using a semistructured pro forma. Depressive disorder was diagnosed using International classification of diseases-10 (ICD-10), and severity was measured using Hamilton rating scale for depression (HAM-D). The weight, height, waist circumference (WC), systolic and diastolic blood pressure (BP), as well as fasting lipids and glucose were measured. Metabolic syndrome was diagnosed based on National Cholesterol Education Program/Adult Treatment Panel (NCEP ATP-III) criteria (2005 revision). The descriptive and inferential statistics were done using statistical package for social sciences (SPSS) 16.
Results and conclusion: The overall prevalence of MS among depressed patients was 35%. The prevalence among “drug-naive” patients was 30%, whereas among “on-drug” patients was 40%. The most common abnormal MS components were WC (53.33%), systolic BP (SBP) (53.3%), and high-density lipoprotein (HDL) (53.3%). Age of the patient was the only sociodemographic factor that showed significant correlation with components of MS like fasting blood sugar (FBS) and SBP. Age of onset of depression among MS cases had a negative correlation with WC. Among the MS components, the distribution of diastolic BP (DBP) and triglycerides (TG) was statistically different among the “drug-naive” and “on-drug” groups. Thus, in view of significant number of depressed patients being at risk of developing MS, it would be necessary to keep a regular check on metabolic parameters in this group of patients. |
| format | Article |
| id | doaj-art-2d81ab73918242609dda0bb7ec033bcb |
| institution | DOAJ |
| issn | 2319-5363 2583-4010 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | Jaypee Brothers Medical Publisher |
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| series | Indian Journal of Private Psychiatry |
| spelling | doaj-art-2d81ab73918242609dda0bb7ec033bcb2025-08-20T03:18:15ZengJaypee Brothers Medical PublisherIndian Journal of Private Psychiatry2319-53632583-40102023-02-01171343910.5005/jp-journals-10067-01297Metabolic Syndrome in Patients with Depression: A Cross-sectional Comparative StudyAjay Prakash0Sourabh S1Prashanth Nagabhushan Rudra2Shankar Kumar3https://orcid.org/0000-0002-8002-4576Shalu Elizabeth Abraham4Department of Psychiatry, North Western Mental Health, Melbourne, AustraliaDepartment of Psychiatry, Bangalore Medical College & Research Institute, Bengaluru, Karnataka, IndiaDepartment of Psychiatry, Bangalore Medical College & Research Institute, Bengaluru, Karnataka, IndiaShankar Kumar, Department of Psychiatry, Bangalore Medical College & Research Institute, St John’s Medical College Hospital, Bengaluru, Karnataka, India, Phone: +91 9844546083Department of Psychiatry, Bangalore Medical College & Research Institute, Bengaluru, Karnataka, IndiaBackground: Depression is a leading cause of disability worldwide and is also known to be comorbid with a number of medical and psychiatric illnesses. Metabolic syndrome (MS) that is now emerging as a common lifestyle illness is found to be twofold greater in patients with depression. Often, antidepressants have been considered to be the reason for this possible link, however, research from the West suggests that a direct link is plausible. There is a scarcity of literature supporting these data from the East. In this study, we have attempted to assess the prevalence of MS in depressive patients, and to determine the probable risk factors contributing to the association. Materials and methods: Sixty consecutive patients that fulfilled the inclusion criteria were recruited from a tertiary care center in India. Sociodemographic and clinical data were obtained using a semistructured pro forma. Depressive disorder was diagnosed using International classification of diseases-10 (ICD-10), and severity was measured using Hamilton rating scale for depression (HAM-D). The weight, height, waist circumference (WC), systolic and diastolic blood pressure (BP), as well as fasting lipids and glucose were measured. Metabolic syndrome was diagnosed based on National Cholesterol Education Program/Adult Treatment Panel (NCEP ATP-III) criteria (2005 revision). The descriptive and inferential statistics were done using statistical package for social sciences (SPSS) 16. Results and conclusion: The overall prevalence of MS among depressed patients was 35%. The prevalence among “drug-naive” patients was 30%, whereas among “on-drug” patients was 40%. The most common abnormal MS components were WC (53.33%), systolic BP (SBP) (53.3%), and high-density lipoprotein (HDL) (53.3%). Age of the patient was the only sociodemographic factor that showed significant correlation with components of MS like fasting blood sugar (FBS) and SBP. Age of onset of depression among MS cases had a negative correlation with WC. Among the MS components, the distribution of diastolic BP (DBP) and triglycerides (TG) was statistically different among the “drug-naive” and “on-drug” groups. Thus, in view of significant number of depressed patients being at risk of developing MS, it would be necessary to keep a regular check on metabolic parameters in this group of patients.https://www.ijiapp.com/doi/IJPP/pdf/10.5005/jp-journals-10067-0129antidepressantdepressionmetabolic syndromewaist circumference |
| spellingShingle | Ajay Prakash Sourabh S Prashanth Nagabhushan Rudra Shankar Kumar Shalu Elizabeth Abraham Metabolic Syndrome in Patients with Depression: A Cross-sectional Comparative Study Indian Journal of Private Psychiatry antidepressant depression metabolic syndrome waist circumference |
| title | Metabolic Syndrome in Patients with Depression: A Cross-sectional Comparative Study |
| title_full | Metabolic Syndrome in Patients with Depression: A Cross-sectional Comparative Study |
| title_fullStr | Metabolic Syndrome in Patients with Depression: A Cross-sectional Comparative Study |
| title_full_unstemmed | Metabolic Syndrome in Patients with Depression: A Cross-sectional Comparative Study |
| title_short | Metabolic Syndrome in Patients with Depression: A Cross-sectional Comparative Study |
| title_sort | metabolic syndrome in patients with depression a cross sectional comparative study |
| topic | antidepressant depression metabolic syndrome waist circumference |
| url | https://www.ijiapp.com/doi/IJPP/pdf/10.5005/jp-journals-10067-0129 |
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