Seizures following Intoxication with a Common Antituberculosis Drug
Isoniazid is an antimycobacterial agent commonly prescribed in most tuberculosis chemotherapy regimens. Its side effects are widely known including mainly liver toxicity and peripheral neuropathy. The toxic effects of isoniazid are dose-related. Toxic doses are estimated at 35–40 mg/kg and fatal dos...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2019/8972574 |
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| _version_ | 1849693435235139584 |
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| author | Adnane Lahlou Saïd Benlamkaddem Mohamed Adnane Berdai Mustapha Harandou |
| author_facet | Adnane Lahlou Saïd Benlamkaddem Mohamed Adnane Berdai Mustapha Harandou |
| author_sort | Adnane Lahlou |
| collection | DOAJ |
| description | Isoniazid is an antimycobacterial agent commonly prescribed in most tuberculosis chemotherapy regimens. Its side effects are widely known including mainly liver toxicity and peripheral neuropathy. The toxic effects of isoniazid are dose-related. Toxic doses are estimated at 35–40 mg/kg and fatal doses at 150 mg/kg. Treatment consists primarily of basic life support, antiepileptic drugs, and pyridoxine. The case is of one of the children with intentional isoniazid poisoning, the drug belonging to an uncle currently under antituberculosis treatment, resulting in tonic-clonic seizures. During her hospitalization in the paediatric intensive care unit, her neurological status as well as her lab values was closely monitored, and despite initial deterioration, the patient was discharged from critical care a week after full recovery. |
| format | Article |
| id | doaj-art-2d7f2ac97c0f45168fbf41445415a1f9 |
| institution | DOAJ |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-2d7f2ac97c0f45168fbf41445415a1f92025-08-20T03:20:25ZengWileyCase Reports in Pediatrics2090-68032090-68112019-01-01201910.1155/2019/89725748972574Seizures following Intoxication with a Common Antituberculosis DrugAdnane Lahlou0Saïd Benlamkaddem1Mohamed Adnane Berdai2Mustapha Harandou3Obstetric and Pediatric Intensive Care Unit, Hassan II Academic Hospital, Fez, MoroccoObstetric and Pediatric Intensive Care Unit, Hassan II Academic Hospital, Fez, MoroccoObstetric and Pediatric Intensive Care Unit, Hassan II Academic Hospital, Fez, MoroccoObstetric and Pediatric Intensive Care Unit, Hassan II Academic Hospital, Fez, MoroccoIsoniazid is an antimycobacterial agent commonly prescribed in most tuberculosis chemotherapy regimens. Its side effects are widely known including mainly liver toxicity and peripheral neuropathy. The toxic effects of isoniazid are dose-related. Toxic doses are estimated at 35–40 mg/kg and fatal doses at 150 mg/kg. Treatment consists primarily of basic life support, antiepileptic drugs, and pyridoxine. The case is of one of the children with intentional isoniazid poisoning, the drug belonging to an uncle currently under antituberculosis treatment, resulting in tonic-clonic seizures. During her hospitalization in the paediatric intensive care unit, her neurological status as well as her lab values was closely monitored, and despite initial deterioration, the patient was discharged from critical care a week after full recovery.http://dx.doi.org/10.1155/2019/8972574 |
| spellingShingle | Adnane Lahlou Saïd Benlamkaddem Mohamed Adnane Berdai Mustapha Harandou Seizures following Intoxication with a Common Antituberculosis Drug Case Reports in Pediatrics |
| title | Seizures following Intoxication with a Common Antituberculosis Drug |
| title_full | Seizures following Intoxication with a Common Antituberculosis Drug |
| title_fullStr | Seizures following Intoxication with a Common Antituberculosis Drug |
| title_full_unstemmed | Seizures following Intoxication with a Common Antituberculosis Drug |
| title_short | Seizures following Intoxication with a Common Antituberculosis Drug |
| title_sort | seizures following intoxication with a common antituberculosis drug |
| url | http://dx.doi.org/10.1155/2019/8972574 |
| work_keys_str_mv | AT adnanelahlou seizuresfollowingintoxicationwithacommonantituberculosisdrug AT saidbenlamkaddem seizuresfollowingintoxicationwithacommonantituberculosisdrug AT mohamedadnaneberdai seizuresfollowingintoxicationwithacommonantituberculosisdrug AT mustaphaharandou seizuresfollowingintoxicationwithacommonantituberculosisdrug |