The risk of hyperuricemia assessed by estimated glucose disposal rate
PurposeThe estimated glucose disposal rate (eGDR) is a simple and noninvasive clinical measure used to assess insulin resistance (IR), yet its potential utility as a marker for hyperuricemia risk had not been systematically evaluated. This study aimed to investigate the relationship between eGDR and...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1567789/full |
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| author | Zhaoxiang Wang Ruoshuang Liu Fengyan Tang Yirong Shen |
| author_facet | Zhaoxiang Wang Ruoshuang Liu Fengyan Tang Yirong Shen |
| author_sort | Zhaoxiang Wang |
| collection | DOAJ |
| description | PurposeThe estimated glucose disposal rate (eGDR) is a simple and noninvasive clinical measure used to assess insulin resistance (IR), yet its potential utility as a marker for hyperuricemia risk had not been systematically evaluated. This study aimed to investigate the relationship between eGDR and hyperuricemia risk among American adults.MethodsData for this cross-sectional study were obtained from the 2007–2018 National Health and Nutrition Examination Survey (NHANES). Hyperuricemia was identified as a serum urate (SU) concentration of ≥7 mg/dL in males and ≥6 mg/dL in females. The relationship between eGDR and hyperuricemia risk was assessed using multivariate logistic regression and restricted cubic spline (RCS) methods, with additional subgroup and interaction analyses performed.ResultsWith increasing eGDR values, the prevalence of hyperuricemia decreased significantly (29.93% vs. 19.11% vs. 13.20% vs. 5.03%, P<0.001). Multivariate logistic regression indicated that eGDR was independently associated with the risk of hyperuricemia after controlling for covariates including demographic, lifestyle, and clinical factors (OR=0.93, 95%CI: 0.90-0.96, P<0.001). RCS analysis further revealed a nonlinear relationship, with a turning point at eGDR 7.96 mg/kg/min. Subgroup analysis revealed a stronger inverse association between eGDR and hyperuricemia risk in females.ConclusionsThe eGDR is inversely associated with hyperuricemia and appears to be a promising epidemiological tool for evaluating the impact of IR on the risk of hyperuricemia. |
| format | Article |
| id | doaj-art-2d79397e3e5343e7bf8b0bf9a237d410 |
| institution | OA Journals |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-2d79397e3e5343e7bf8b0bf9a237d4102025-08-20T02:07:46ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-06-011610.3389/fendo.2025.15677891567789The risk of hyperuricemia assessed by estimated glucose disposal rateZhaoxiang Wang0Ruoshuang Liu1Fengyan Tang2Yirong Shen3Department of Endocrinology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, Jiangsu, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of Endocrinology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, Jiangsu, ChinaDepartment of Clinical Nutrition, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, ChinaPurposeThe estimated glucose disposal rate (eGDR) is a simple and noninvasive clinical measure used to assess insulin resistance (IR), yet its potential utility as a marker for hyperuricemia risk had not been systematically evaluated. This study aimed to investigate the relationship between eGDR and hyperuricemia risk among American adults.MethodsData for this cross-sectional study were obtained from the 2007–2018 National Health and Nutrition Examination Survey (NHANES). Hyperuricemia was identified as a serum urate (SU) concentration of ≥7 mg/dL in males and ≥6 mg/dL in females. The relationship between eGDR and hyperuricemia risk was assessed using multivariate logistic regression and restricted cubic spline (RCS) methods, with additional subgroup and interaction analyses performed.ResultsWith increasing eGDR values, the prevalence of hyperuricemia decreased significantly (29.93% vs. 19.11% vs. 13.20% vs. 5.03%, P<0.001). Multivariate logistic regression indicated that eGDR was independently associated with the risk of hyperuricemia after controlling for covariates including demographic, lifestyle, and clinical factors (OR=0.93, 95%CI: 0.90-0.96, P<0.001). RCS analysis further revealed a nonlinear relationship, with a turning point at eGDR 7.96 mg/kg/min. Subgroup analysis revealed a stronger inverse association between eGDR and hyperuricemia risk in females.ConclusionsThe eGDR is inversely associated with hyperuricemia and appears to be a promising epidemiological tool for evaluating the impact of IR on the risk of hyperuricemia.https://www.frontiersin.org/articles/10.3389/fendo.2025.1567789/fullhyperuricemiainsulin resistanceestimated glucose disposal rateNHANESpopulation-based study |
| spellingShingle | Zhaoxiang Wang Ruoshuang Liu Fengyan Tang Yirong Shen The risk of hyperuricemia assessed by estimated glucose disposal rate Frontiers in Endocrinology hyperuricemia insulin resistance estimated glucose disposal rate NHANES population-based study |
| title | The risk of hyperuricemia assessed by estimated glucose disposal rate |
| title_full | The risk of hyperuricemia assessed by estimated glucose disposal rate |
| title_fullStr | The risk of hyperuricemia assessed by estimated glucose disposal rate |
| title_full_unstemmed | The risk of hyperuricemia assessed by estimated glucose disposal rate |
| title_short | The risk of hyperuricemia assessed by estimated glucose disposal rate |
| title_sort | risk of hyperuricemia assessed by estimated glucose disposal rate |
| topic | hyperuricemia insulin resistance estimated glucose disposal rate NHANES population-based study |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1567789/full |
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