Application of loaded graphene oxide biomaterials in the repair and treatment of bone defects: a review
Addressing bone defects is a complex medical challenge that involves dealing with various skeletal conditions, including fractures, osteoporosis (OP), bone tumours, and bone infection defects. Despite the availability of multiple conventional treatments for these skeletal conditions, numerous limita...
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| Format: | Article |
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The British Editorial Society of Bone & Joint Surgery
2024-12-01
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| Series: | Bone & Joint Research |
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| Online Access: | https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.1312.BJR-2024-0048.R1 |
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| author | Jinyi Xing Shuzhong Liu |
| author_facet | Jinyi Xing Shuzhong Liu |
| author_sort | Jinyi Xing |
| collection | DOAJ |
| description | Addressing bone defects is a complex medical challenge that involves dealing with various skeletal conditions, including fractures, osteoporosis (OP), bone tumours, and bone infection defects. Despite the availability of multiple conventional treatments for these skeletal conditions, numerous limitations and unresolved issues persist. As a solution, advancements in biomedical materials have recently resulted in novel therapeutic concepts. As an emerging biomaterial for bone defect treatment, graphene oxide (GO) in particular has gained substantial attention from researchers due to its potential applications and prospects. In other words, GO scaffolds have demonstrated remarkable potential for bone defect treatment. Furthermore, GO-loaded biomaterials can promote osteoblast adhesion, proliferation, and differentiation while stimulating bone matrix deposition and formation. Given their favourable biocompatibility and osteoinductive capabilities, these materials offer a novel therapeutic avenue for bone tissue regeneration and repair. This comprehensive review systematically outlines GO scaffolds’ diverse roles and potential applications in bone defect treatment. Cite this article: Bone Joint Res 2024;13(12):725–740. |
| format | Article |
| id | doaj-art-2d75b805a76445a287368870b225600b |
| institution | Kabale University |
| issn | 2046-3758 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | The British Editorial Society of Bone & Joint Surgery |
| record_format | Article |
| series | Bone & Joint Research |
| spelling | doaj-art-2d75b805a76445a287368870b225600b2025-01-28T06:54:06ZengThe British Editorial Society of Bone & Joint SurgeryBone & Joint Research2046-37582024-12-01131272574010.1302/2046-3758.1312.BJR-2024-0048.R1Application of loaded graphene oxide biomaterials in the repair and treatment of bone defects: a reviewJinyi Xing0https://orcid.org/0009-0006-3785-8184Shuzhong Liu1https://orcid.org/0000-0002-0592-2288Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaAddressing bone defects is a complex medical challenge that involves dealing with various skeletal conditions, including fractures, osteoporosis (OP), bone tumours, and bone infection defects. Despite the availability of multiple conventional treatments for these skeletal conditions, numerous limitations and unresolved issues persist. As a solution, advancements in biomedical materials have recently resulted in novel therapeutic concepts. As an emerging biomaterial for bone defect treatment, graphene oxide (GO) in particular has gained substantial attention from researchers due to its potential applications and prospects. In other words, GO scaffolds have demonstrated remarkable potential for bone defect treatment. Furthermore, GO-loaded biomaterials can promote osteoblast adhesion, proliferation, and differentiation while stimulating bone matrix deposition and formation. Given their favourable biocompatibility and osteoinductive capabilities, these materials offer a novel therapeutic avenue for bone tissue regeneration and repair. This comprehensive review systematically outlines GO scaffolds’ diverse roles and potential applications in bone defect treatment. Cite this article: Bone Joint Res 2024;13(12):725–740.https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.1312.BJR-2024-0048.R1graphene oxidenanocompositesbone defectbone defect repairbone tissue engineeringscaffoldbiomaterialsbone defectsosteoblastsosteoporotic bonebone infectionstumours and bonebone tissue regenerationbone matrixcompositesbone regeneration |
| spellingShingle | Jinyi Xing Shuzhong Liu Application of loaded graphene oxide biomaterials in the repair and treatment of bone defects: a review Bone & Joint Research graphene oxide nanocomposites bone defect bone defect repair bone tissue engineering scaffold biomaterials bone defects osteoblasts osteoporotic bone bone infections tumours and bone bone tissue regeneration bone matrix composites bone regeneration |
| title | Application of loaded graphene oxide biomaterials in the repair and treatment of bone defects: a review |
| title_full | Application of loaded graphene oxide biomaterials in the repair and treatment of bone defects: a review |
| title_fullStr | Application of loaded graphene oxide biomaterials in the repair and treatment of bone defects: a review |
| title_full_unstemmed | Application of loaded graphene oxide biomaterials in the repair and treatment of bone defects: a review |
| title_short | Application of loaded graphene oxide biomaterials in the repair and treatment of bone defects: a review |
| title_sort | application of loaded graphene oxide biomaterials in the repair and treatment of bone defects a review |
| topic | graphene oxide nanocomposites bone defect bone defect repair bone tissue engineering scaffold biomaterials bone defects osteoblasts osteoporotic bone bone infections tumours and bone bone tissue regeneration bone matrix composites bone regeneration |
| url | https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.1312.BJR-2024-0048.R1 |
| work_keys_str_mv | AT jinyixing applicationofloadedgrapheneoxidebiomaterialsintherepairandtreatmentofbonedefectsareview AT shuzhongliu applicationofloadedgrapheneoxidebiomaterialsintherepairandtreatmentofbonedefectsareview |