PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism.

PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism.

Peroxisome proliferator activated receptor gamma 2 (PPARg2) is the nutritionally regulated isoform of PPARg. Ablation of PPARg2 in the ob/ob background, PPARg2(-/-) Lep(ob)/Lep(ob) (POKO mouse), resulted in decreased fat mass, severe insulin resistance, beta-cell failure, and dyslipidaemia. Our resu...

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Main Authors: Gema Medina-Gomez, Sarah L Gray, Laxman Yetukuri, Kenju Shimomura, Sam Virtue, Mark Campbell, R Keira Curtis, Mercedes Jimenez-Linan, Margaret Blount, Giles S H Yeo, Miguel Lopez, Tuulikki Seppänen-Laakso, Frances M Ashcroft, Matej Oresic, Antonio Vidal-Puig
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-04-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0030064&type=printable
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