A study of clinical profile of primary extranodal lymphomas in a tertiary care institute in South India
Context: Primary extranodal lymphoma (pENL) refers to group of disorders arising from tissues other than lymph nodes. The incidence of pENL is increasing and is probably due to better diagnostic immunophenotyping and imaging modalities. Hence, this study was undertaken to ascertain the incidence, di...
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2017-01-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
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| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2017;volume=38;issue=3;spage=251;epage=255;aulast=Pai |
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| author | Ananth Pai Thiruvengadasamy Kannan R G Balambika Vindhya Vasini |
| author_facet | Ananth Pai Thiruvengadasamy Kannan R G Balambika Vindhya Vasini |
| author_sort | Ananth Pai |
| collection | DOAJ |
| description | Context: Primary extranodal lymphoma (pENL) refers to group of disorders arising from tissues other than lymph nodes. The incidence of pENL is increasing and is probably due to better diagnostic immunophenotyping and imaging modalities. Hence, this study was undertaken to ascertain the incidence, distribution, and histological subtypes of extranodal non-Hodgkin lymphoma (NHL) in a tertiary care institute in South India. Subjects and Methods: This was a retrospective study of patients diagnosed to have histologically proven NHL. The demographic and clinical features, laboratory parameters, imaging findings, histopathology, and immunophenotyping were documented. The lymphomas were grouped as extranodal and nodal. The data were tabulated in a Microsoft Excel sheet, and descriptive analysis was done. Results: Primary extranodal NHLs constituted 35.96% (41/114) of all NHLs. The B symptoms were less common in pENL compared to nodal NHL. Gastrointestinal tract (GIT) constituted the most common extranodal site (19/41, 46.34%), and diffuse large B-cell lymphoma (DLBCL) was the most common histological subtype. Majority (40/41, 97%) of the patients with pENL were immunocompetent. 31/41 (75%) patients were in Stage I–II compared to 58/73 (79.4%) patients in Stage III–IV in nodal NHL. Conclusions: Primary extranodal NHL constituted about one-third of patients diagnosed to have NHL at our center with the GIT being the most common site of presentation and DLBCL being the most common histology. A strong suspicion of NHL at an extranodal site with appropriate pathological and immunophenotyping evidence is needed to establish the diagnosis of a pENL. |
| format | Article |
| id | doaj-art-2d6bdbfc8a80488f9d3d1072e7840cda |
| institution | OA Journals |
| issn | 0971-5851 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-2d6bdbfc8a80488f9d3d1072e7840cda2025-08-20T02:01:39ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58512017-01-0138325125510.4103/ijmpo.ijmpo_82_16A study of clinical profile of primary extranodal lymphomas in a tertiary care institute in South IndiaAnanth PaiThiruvengadasamy KannanR G BalambikaVindhya VasiniContext: Primary extranodal lymphoma (pENL) refers to group of disorders arising from tissues other than lymph nodes. The incidence of pENL is increasing and is probably due to better diagnostic immunophenotyping and imaging modalities. Hence, this study was undertaken to ascertain the incidence, distribution, and histological subtypes of extranodal non-Hodgkin lymphoma (NHL) in a tertiary care institute in South India. Subjects and Methods: This was a retrospective study of patients diagnosed to have histologically proven NHL. The demographic and clinical features, laboratory parameters, imaging findings, histopathology, and immunophenotyping were documented. The lymphomas were grouped as extranodal and nodal. The data were tabulated in a Microsoft Excel sheet, and descriptive analysis was done. Results: Primary extranodal NHLs constituted 35.96% (41/114) of all NHLs. The B symptoms were less common in pENL compared to nodal NHL. Gastrointestinal tract (GIT) constituted the most common extranodal site (19/41, 46.34%), and diffuse large B-cell lymphoma (DLBCL) was the most common histological subtype. Majority (40/41, 97%) of the patients with pENL were immunocompetent. 31/41 (75%) patients were in Stage I–II compared to 58/73 (79.4%) patients in Stage III–IV in nodal NHL. Conclusions: Primary extranodal NHL constituted about one-third of patients diagnosed to have NHL at our center with the GIT being the most common site of presentation and DLBCL being the most common histology. A strong suspicion of NHL at an extranodal site with appropriate pathological and immunophenotyping evidence is needed to establish the diagnosis of a pENL.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2017;volume=38;issue=3;spage=251;epage=255;aulast=PaiDiffuse large B cellextranodallymphomaNon-Hodgkin |
| spellingShingle | Ananth Pai Thiruvengadasamy Kannan R G Balambika Vindhya Vasini A study of clinical profile of primary extranodal lymphomas in a tertiary care institute in South India Indian Journal of Medical and Paediatric Oncology Diffuse large B cell extranodal lymphoma Non-Hodgkin |
| title | A study of clinical profile of primary extranodal lymphomas in a tertiary care institute in South India |
| title_full | A study of clinical profile of primary extranodal lymphomas in a tertiary care institute in South India |
| title_fullStr | A study of clinical profile of primary extranodal lymphomas in a tertiary care institute in South India |
| title_full_unstemmed | A study of clinical profile of primary extranodal lymphomas in a tertiary care institute in South India |
| title_short | A study of clinical profile of primary extranodal lymphomas in a tertiary care institute in South India |
| title_sort | study of clinical profile of primary extranodal lymphomas in a tertiary care institute in south india |
| topic | Diffuse large B cell extranodal lymphoma Non-Hodgkin |
| url | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2017;volume=38;issue=3;spage=251;epage=255;aulast=Pai |
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