The Relationship between Estimated Glomerular Filtration Rate and Diabetic Retinopathy
Diabetic retinopathy (DR) is the leading cause of visual impairment and blindness in working-aged people. Several studies have suggested that glomerular filtration rate (GFR) was correlated with DR. This is a hospital-based study and the aim of it was to examine the relationship between the GFR and...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2015/326209 |
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| author | Jingyang Wu Jin Geng Limin Liu Weiping Teng Lei Liu Lei Chen |
| author_facet | Jingyang Wu Jin Geng Limin Liu Weiping Teng Lei Liu Lei Chen |
| author_sort | Jingyang Wu |
| collection | DOAJ |
| description | Diabetic retinopathy (DR) is the leading cause of visual impairment and blindness in working-aged people. Several studies have suggested that glomerular filtration rate (GFR) was correlated with DR. This is a hospital-based study and the aim of it was to examine the relationship between the GFR and DR in patients with type 2 diabetes mellitus (T2DM). We used CKD-EPI equation to estimate GFR and SPSS 19.0 and EmpowerStats software to assess their relationship. Among the 1613 participants (aged 54.75 ± 12.19 years), 550 (34.1%) patients suffered from DR. The multivariate analysis revealed that the risk factors for DR include age (P<0.001, OR = 0.940), duration of diabetes (P<0.001, OR = 1.163), hemoglobin A1c (P=0.007, OR = 1.224), systolic blood pressure (P<0.001, OR = 1.032), diastolic blood pressure (P=0.007, OR = 0.953), high density lipoprotein cholesterol (P=0.024, OR = 3.884), and eGFR (P=0.010, OR = 0.973). Through stratified analysis and saturation effect analysis, our data suggests that eGFR of 99.4 mL/min or lower might imply the early stage of DR in diabetic patients. Thus, the evaluation of eGFR has clinical significance for the early diagnosis of DR. |
| format | Article |
| id | doaj-art-2d6972ca5a164ba1b1089a5a7a39e89f |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-2d6972ca5a164ba1b1089a5a7a39e89f2025-02-03T01:32:43ZengWileyJournal of Ophthalmology2090-004X2090-00582015-01-01201510.1155/2015/326209326209The Relationship between Estimated Glomerular Filtration Rate and Diabetic RetinopathyJingyang Wu0Jin Geng1Limin Liu2Weiping Teng3Lei Liu4Lei Chen5Department of Ophthalmology, The First Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Ophthalmology, The First Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Ophthalmology, The First Hospital of China Medical University, Shenyang 110001, ChinaKey Laboratory of Endocrine Diseases of Liaoning Province, The First Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Ophthalmology, The First Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Ophthalmology, The First Hospital of China Medical University, Shenyang 110001, ChinaDiabetic retinopathy (DR) is the leading cause of visual impairment and blindness in working-aged people. Several studies have suggested that glomerular filtration rate (GFR) was correlated with DR. This is a hospital-based study and the aim of it was to examine the relationship between the GFR and DR in patients with type 2 diabetes mellitus (T2DM). We used CKD-EPI equation to estimate GFR and SPSS 19.0 and EmpowerStats software to assess their relationship. Among the 1613 participants (aged 54.75 ± 12.19 years), 550 (34.1%) patients suffered from DR. The multivariate analysis revealed that the risk factors for DR include age (P<0.001, OR = 0.940), duration of diabetes (P<0.001, OR = 1.163), hemoglobin A1c (P=0.007, OR = 1.224), systolic blood pressure (P<0.001, OR = 1.032), diastolic blood pressure (P=0.007, OR = 0.953), high density lipoprotein cholesterol (P=0.024, OR = 3.884), and eGFR (P=0.010, OR = 0.973). Through stratified analysis and saturation effect analysis, our data suggests that eGFR of 99.4 mL/min or lower might imply the early stage of DR in diabetic patients. Thus, the evaluation of eGFR has clinical significance for the early diagnosis of DR.http://dx.doi.org/10.1155/2015/326209 |
| spellingShingle | Jingyang Wu Jin Geng Limin Liu Weiping Teng Lei Liu Lei Chen The Relationship between Estimated Glomerular Filtration Rate and Diabetic Retinopathy Journal of Ophthalmology |
| title | The Relationship between Estimated Glomerular Filtration Rate and Diabetic Retinopathy |
| title_full | The Relationship between Estimated Glomerular Filtration Rate and Diabetic Retinopathy |
| title_fullStr | The Relationship between Estimated Glomerular Filtration Rate and Diabetic Retinopathy |
| title_full_unstemmed | The Relationship between Estimated Glomerular Filtration Rate and Diabetic Retinopathy |
| title_short | The Relationship between Estimated Glomerular Filtration Rate and Diabetic Retinopathy |
| title_sort | relationship between estimated glomerular filtration rate and diabetic retinopathy |
| url | http://dx.doi.org/10.1155/2015/326209 |
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