A vascular endothelial growth factor–loaded chitosan-hyaluronic acid hydrogel scaffold enhances the therapeutic effect of adipose-derived stem cells in the context of stroke

A vascular endothelial growth factor–loaded chitosan-hyaluronic acid hydrogel scaffold enhances the therapeutic effect of adipose-derived stem cells in the context of stroke

Adipose-derived stem cell, one type of mesenchymal stem cells, is a promising approach in treating ischemia-reperfusion injury caused by occlusion of the middle cerebral artery. However, its application has been limited by the complexities of the ischemic microenvironment. Hydrogel scaffolds, which...

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Bibliographic Details
Main Authors: Zhijian Zheng, Xiaohui Lin, Zijun Zhao, Qiang Lin, Ji Liu, Manli Chen, Wenwen Wu, Zhiyun Wu, Nan Liu, Hongbin Chen
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-12-01
Series:Neural Regeneration Research
Subjects:
adipose-derived stem cells
chitosan
hyaluronic acid
hydrogel
ischemia-reperfusion
oxygen-glucose deprivation/reoxygenation
stroke
transient middle cerebral artery occlusion
transplantation
vascular endothelial growth factor
Online Access:https://journals.lww.com/10.4103/NRR.NRR-D-24-00129
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