Associations between β-Blocker Therapy at Discharge and Long-Term Follow-Up Outcomes in Patients with Unstable Angina Pectoris
Background. The effects of β-blockers in patients with unstable angina pectoris (UAP) are unclear. We tried to evaluate associations between β-blockers in UAP and long-term outcomes. Methods. We enrolled 5591 UAP patients and divided them into 2 groups based on β-blockers at discharge: 3790 did β-bl...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2022/5287566 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849693431282008064 |
|---|---|
| author | Lei Liu Xiaosong Ding Hui Chen Weiping Li Hongwei Li |
| author_facet | Lei Liu Xiaosong Ding Hui Chen Weiping Li Hongwei Li |
| author_sort | Lei Liu |
| collection | DOAJ |
| description | Background. The effects of β-blockers in patients with unstable angina pectoris (UAP) are unclear. We tried to evaluate associations between β-blockers in UAP and long-term outcomes. Methods. We enrolled 5591 UAP patients and divided them into 2 groups based on β-blockers at discharge: 3790 did β-blockers and 1801 did not used them. Propensity score matching at 1 : 1 was performed to select 1786 patients from each group. The primary endpoint was major adverse cardiac and cerebral events (MACCE) during the long-term follow-up period. Results. 67.8% of patients were on β-blockers at discharge; these patients were more likely to have CHD risk factors, lower ejection fraction, and severity of the coronary artery lesions. Over a median of 25.0 years, the incidence of MACCE was 25.5%. The risk was not significantly different between those on and those not on β-blocker treatment. The multivariate Cox regression analysis showed that no β-blocker use at discharge was not an independent risk factor for MACCE and sequence secondary endpoints. After propensity score matching, the results were similar. Conclusions. β-blocker use was not associated with lower MACCE and other secondary composite endpoints in long-term outcomes. This result adds to the increasing body of evidence that the routine prescription of β-blockers might not be indicated in patients with UAP. Trial registration had retrospectively registered. |
| format | Article |
| id | doaj-art-2d63434f81f145b982e687426f68f6ee |
| institution | DOAJ |
| issn | 2090-0597 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-2d63434f81f145b982e687426f68f6ee2025-08-20T03:20:25ZengWileyCardiology Research and Practice2090-05972022-01-01202210.1155/2022/5287566Associations between β-Blocker Therapy at Discharge and Long-Term Follow-Up Outcomes in Patients with Unstable Angina PectorisLei Liu0Xiaosong Ding1Hui Chen2Weiping Li3Hongwei Li4Department of CardiologyDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyBackground. The effects of β-blockers in patients with unstable angina pectoris (UAP) are unclear. We tried to evaluate associations between β-blockers in UAP and long-term outcomes. Methods. We enrolled 5591 UAP patients and divided them into 2 groups based on β-blockers at discharge: 3790 did β-blockers and 1801 did not used them. Propensity score matching at 1 : 1 was performed to select 1786 patients from each group. The primary endpoint was major adverse cardiac and cerebral events (MACCE) during the long-term follow-up period. Results. 67.8% of patients were on β-blockers at discharge; these patients were more likely to have CHD risk factors, lower ejection fraction, and severity of the coronary artery lesions. Over a median of 25.0 years, the incidence of MACCE was 25.5%. The risk was not significantly different between those on and those not on β-blocker treatment. The multivariate Cox regression analysis showed that no β-blocker use at discharge was not an independent risk factor for MACCE and sequence secondary endpoints. After propensity score matching, the results were similar. Conclusions. β-blocker use was not associated with lower MACCE and other secondary composite endpoints in long-term outcomes. This result adds to the increasing body of evidence that the routine prescription of β-blockers might not be indicated in patients with UAP. Trial registration had retrospectively registered.http://dx.doi.org/10.1155/2022/5287566 |
| spellingShingle | Lei Liu Xiaosong Ding Hui Chen Weiping Li Hongwei Li Associations between β-Blocker Therapy at Discharge and Long-Term Follow-Up Outcomes in Patients with Unstable Angina Pectoris Cardiology Research and Practice |
| title | Associations between β-Blocker Therapy at Discharge and Long-Term Follow-Up Outcomes in Patients with Unstable Angina Pectoris |
| title_full | Associations between β-Blocker Therapy at Discharge and Long-Term Follow-Up Outcomes in Patients with Unstable Angina Pectoris |
| title_fullStr | Associations between β-Blocker Therapy at Discharge and Long-Term Follow-Up Outcomes in Patients with Unstable Angina Pectoris |
| title_full_unstemmed | Associations between β-Blocker Therapy at Discharge and Long-Term Follow-Up Outcomes in Patients with Unstable Angina Pectoris |
| title_short | Associations between β-Blocker Therapy at Discharge and Long-Term Follow-Up Outcomes in Patients with Unstable Angina Pectoris |
| title_sort | associations between β blocker therapy at discharge and long term follow up outcomes in patients with unstable angina pectoris |
| url | http://dx.doi.org/10.1155/2022/5287566 |
| work_keys_str_mv | AT leiliu associationsbetweenbblockertherapyatdischargeandlongtermfollowupoutcomesinpatientswithunstableanginapectoris AT xiaosongding associationsbetweenbblockertherapyatdischargeandlongtermfollowupoutcomesinpatientswithunstableanginapectoris AT huichen associationsbetweenbblockertherapyatdischargeandlongtermfollowupoutcomesinpatientswithunstableanginapectoris AT weipingli associationsbetweenbblockertherapyatdischargeandlongtermfollowupoutcomesinpatientswithunstableanginapectoris AT hongweili associationsbetweenbblockertherapyatdischargeandlongtermfollowupoutcomesinpatientswithunstableanginapectoris |