Effective and new technologies in kidney tissue engineering
Kidney disease encompasses a wide spectrum of conditions, ranging from simple infections to chronic kidney disease. When the kidneys are unable to filter blood and remove waste products, these abnormalities can lead to kidney failure. In severe cases of kidney failure, kidney transplantation is cons...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-10-01
|
| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1476510/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850284270615003136 |
|---|---|
| author | Hossein Rayat Pisheh Hossein Rayat Pisheh Mobin Haghdel Mahboube Jahangir Mahboube Jahangir Monireh Sadat Hoseinian Monireh Sadat Hoseinian Shaghayegh Rostami Yasuj Shaghayegh Rostami Yasuj Ali Sarhadi Roodbari Ali Sarhadi Roodbari |
| author_facet | Hossein Rayat Pisheh Hossein Rayat Pisheh Mobin Haghdel Mahboube Jahangir Mahboube Jahangir Monireh Sadat Hoseinian Monireh Sadat Hoseinian Shaghayegh Rostami Yasuj Shaghayegh Rostami Yasuj Ali Sarhadi Roodbari Ali Sarhadi Roodbari |
| author_sort | Hossein Rayat Pisheh |
| collection | DOAJ |
| description | Kidney disease encompasses a wide spectrum of conditions, ranging from simple infections to chronic kidney disease. When the kidneys are unable to filter blood and remove waste products, these abnormalities can lead to kidney failure. In severe cases of kidney failure, kidney transplantation is considered the only definitive treatment. Worldwide, the World Health Organization (WHO) repeatedly emphasizes the importance of organ donation and increasing transplantation rates. Many countries implement national programs to promote the culture of organ donation and improve patient access to kidney transplantation. The extent to which this procedure is performed varies across countries and is influenced by several factors, including the volume of organ donation, medical infrastructure, access to technology and health policies. However, a kidney transplant comes with challenges and problems that impact its success. Kidney tissue engineering is a new approach that shows promise for repairing and replacing damaged kidney tissue. This article reviews recent advances in kidney tissue engineering, focusing on engineered structures such as hydrogels, electrospinning, 3D bioprinting, and microfluidic systems. By mimicking the extracellular environment of the kidney, these structures provide suitable conditions for the growth and development of kidney cells. The role of these structures in the formation of blood vessels, the mimicry of kidney functions and the challenges in this field were also discussed. The results of this study show that kidney tissue engineering has high potential for treating kidney diseases and reducing the need for kidney transplantation. However, to achieve clinical application of this technology, further research is required to improve the biocompatibility, vascularization and long-term performance of engineered tissues. |
| format | Article |
| id | doaj-art-2d63045e806a45a8bc5b0ca49ef17ad9 |
| institution | OA Journals |
| issn | 2296-4185 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-2d63045e806a45a8bc5b0ca49ef17ad92025-08-20T01:47:37ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852024-10-011210.3389/fbioe.2024.14765101476510Effective and new technologies in kidney tissue engineeringHossein Rayat Pisheh0Hossein Rayat Pisheh1Mobin Haghdel2Mahboube Jahangir3Mahboube Jahangir4Monireh Sadat Hoseinian5Monireh Sadat Hoseinian6Shaghayegh Rostami Yasuj7Shaghayegh Rostami Yasuj8Ali Sarhadi Roodbari9Ali Sarhadi Roodbari10Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, IranStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Tissue Engineering and Applied Cell Sciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Tissue Engineering and Applied Cell Sciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, IranStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Tissue Engineering and Applied Cell Sciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, IranStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Tissue Engineering and Applied Cell Sciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, IranStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Tissue Engineering and Applied Cell Sciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, IranStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, IranKidney disease encompasses a wide spectrum of conditions, ranging from simple infections to chronic kidney disease. When the kidneys are unable to filter blood and remove waste products, these abnormalities can lead to kidney failure. In severe cases of kidney failure, kidney transplantation is considered the only definitive treatment. Worldwide, the World Health Organization (WHO) repeatedly emphasizes the importance of organ donation and increasing transplantation rates. Many countries implement national programs to promote the culture of organ donation and improve patient access to kidney transplantation. The extent to which this procedure is performed varies across countries and is influenced by several factors, including the volume of organ donation, medical infrastructure, access to technology and health policies. However, a kidney transplant comes with challenges and problems that impact its success. Kidney tissue engineering is a new approach that shows promise for repairing and replacing damaged kidney tissue. This article reviews recent advances in kidney tissue engineering, focusing on engineered structures such as hydrogels, electrospinning, 3D bioprinting, and microfluidic systems. By mimicking the extracellular environment of the kidney, these structures provide suitable conditions for the growth and development of kidney cells. The role of these structures in the formation of blood vessels, the mimicry of kidney functions and the challenges in this field were also discussed. The results of this study show that kidney tissue engineering has high potential for treating kidney diseases and reducing the need for kidney transplantation. However, to achieve clinical application of this technology, further research is required to improve the biocompatibility, vascularization and long-term performance of engineered tissues.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1476510/fulltissue engineeringscaffold3D bioprintingmicrofluidic systemskidney cellskidney diseases |
| spellingShingle | Hossein Rayat Pisheh Hossein Rayat Pisheh Mobin Haghdel Mahboube Jahangir Mahboube Jahangir Monireh Sadat Hoseinian Monireh Sadat Hoseinian Shaghayegh Rostami Yasuj Shaghayegh Rostami Yasuj Ali Sarhadi Roodbari Ali Sarhadi Roodbari Effective and new technologies in kidney tissue engineering Frontiers in Bioengineering and Biotechnology tissue engineering scaffold 3D bioprinting microfluidic systems kidney cells kidney diseases |
| title | Effective and new technologies in kidney tissue engineering |
| title_full | Effective and new technologies in kidney tissue engineering |
| title_fullStr | Effective and new technologies in kidney tissue engineering |
| title_full_unstemmed | Effective and new technologies in kidney tissue engineering |
| title_short | Effective and new technologies in kidney tissue engineering |
| title_sort | effective and new technologies in kidney tissue engineering |
| topic | tissue engineering scaffold 3D bioprinting microfluidic systems kidney cells kidney diseases |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1476510/full |
| work_keys_str_mv | AT hosseinrayatpisheh effectiveandnewtechnologiesinkidneytissueengineering AT hosseinrayatpisheh effectiveandnewtechnologiesinkidneytissueengineering AT mobinhaghdel effectiveandnewtechnologiesinkidneytissueengineering AT mahboubejahangir effectiveandnewtechnologiesinkidneytissueengineering AT mahboubejahangir effectiveandnewtechnologiesinkidneytissueengineering AT monirehsadathoseinian effectiveandnewtechnologiesinkidneytissueengineering AT monirehsadathoseinian effectiveandnewtechnologiesinkidneytissueengineering AT shaghayeghrostamiyasuj effectiveandnewtechnologiesinkidneytissueengineering AT shaghayeghrostamiyasuj effectiveandnewtechnologiesinkidneytissueengineering AT alisarhadiroodbari effectiveandnewtechnologiesinkidneytissueengineering AT alisarhadiroodbari effectiveandnewtechnologiesinkidneytissueengineering |