Hypergravity as a Possible Way of Bone Tissue Engineering in Osteoblastic Differentiation from Mesenchymal Stem Cells: A Systematic Review
Background: Tissue engineering development has become a highlight in recent decades. One of the key areas of focus is producing mature bone tissue to overcome orthopedic problems, such as bone defects. Various cultures have been implemented on stem cells; some induce osteoblastic differentiation mar...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universitas Airlangga
2024-10-01
|
| Series: | Journal Orthopaedi and Traumatology Surabaya |
| Subjects: | |
| Online Access: | https://e-journal.unair.ac.id/JOINTS/article/view/49108 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823856484069408768 |
|---|---|
| author | Wisnu Sudrajad Andre Erica Indrawan Devangga Kusuma Bagus Wibowo Soetojo Heri Suroto |
| author_facet | Wisnu Sudrajad Andre Erica Indrawan Devangga Kusuma Bagus Wibowo Soetojo Heri Suroto |
| author_sort | Wisnu Sudrajad |
| collection | DOAJ |
| description | Background: Tissue engineering development has become a highlight in recent decades. One of the key areas of focus is producing mature bone tissue to overcome orthopedic problems, such as bone defects. Various cultures have been implemented on stem cells; some induce osteoblastic differentiation markers, while others have the opposite effect. Microgravity has been proven in several studies to inhibit the expression of osteogenic differentiation markers. Conversely, hypergravity is expected to have the opposite impact, supporting stem cells in the osteogenesis pathway.
Methods: A literature search was conducted using online databases including Sciencedirect, PubMed, and Proquest, covering the period from 2008 to 2022. This search considered only experimental studies published in English. The keywords used in this research were "hypergravity" and "mesenchymal stem cell." All acquired data were processed and analyzed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines (2020).
Results: Initially, 190 studies were collected from online databases based on relevant keywords. After screening, 5 studies were included in the final analysis, focusing on hypergravity treatment and its effects on mesenchymal stem cells (MSCs).
Conclusion: Hypergravity shows a significant and strong impact on osteoblastic differentiation. This study revealed that a gravity force of 30G and a culture duration of 7 to 14 days are the most optimal combination for inducing osteoblastic differentiation in MSCs. |
| format | Article |
| id | doaj-art-2d5f63bf15614c9199cf1f4a47632f62 |
| institution | Kabale University |
| issn | 2722-712X 2460-8742 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Universitas Airlangga |
| record_format | Article |
| series | Journal Orthopaedi and Traumatology Surabaya |
| spelling | doaj-art-2d5f63bf15614c9199cf1f4a47632f622025-02-12T07:26:43ZengUniversitas AirlanggaJournal Orthopaedi and Traumatology Surabaya2722-712X2460-87422024-10-01132758310.20473/joints.v13i2.2024.75-8347218Hypergravity as a Possible Way of Bone Tissue Engineering in Osteoblastic Differentiation from Mesenchymal Stem Cells: A Systematic ReviewWisnu Sudrajad0https://orcid.org/0009-0002-3790-0793Andre Erica Indrawan1https://orcid.org/0009-0008-0925-8936Devangga Kusuma2https://orcid.org/0009-0001-0519-126XBagus Wibowo Soetojo3https://orcid.org/0009-0007-9736-4220Heri Suroto4https://orcid.org/0000-0002-9384-897XLabuha General Hospital, South Halmahera, Indonesia; Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Department of Orthopaedics and Traumatology, Dr. Soetomo General Academic Hospital, Surabaya, IndonesiaBhakti Wira Tamtama Hospital, Semarang, IndonesiaNgudi Waluyo Wlingi General Hospital, Blitar, IndonesiaDepartment of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Department of Orthopaedics and Traumatology, Dr. Soetomo General Academic Hospital, Surabaya, IndonesiaDepartment of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Department of Orthopaedics and Traumatology, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia; Cell & Tissue Bank Regenerative Medicine, Dr. Soetomo General Academic Hospital, Surabaya, IndonesiaBackground: Tissue engineering development has become a highlight in recent decades. One of the key areas of focus is producing mature bone tissue to overcome orthopedic problems, such as bone defects. Various cultures have been implemented on stem cells; some induce osteoblastic differentiation markers, while others have the opposite effect. Microgravity has been proven in several studies to inhibit the expression of osteogenic differentiation markers. Conversely, hypergravity is expected to have the opposite impact, supporting stem cells in the osteogenesis pathway. Methods: A literature search was conducted using online databases including Sciencedirect, PubMed, and Proquest, covering the period from 2008 to 2022. This search considered only experimental studies published in English. The keywords used in this research were "hypergravity" and "mesenchymal stem cell." All acquired data were processed and analyzed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines (2020). Results: Initially, 190 studies were collected from online databases based on relevant keywords. After screening, 5 studies were included in the final analysis, focusing on hypergravity treatment and its effects on mesenchymal stem cells (MSCs). Conclusion: Hypergravity shows a significant and strong impact on osteoblastic differentiation. This study revealed that a gravity force of 30G and a culture duration of 7 to 14 days are the most optimal combination for inducing osteoblastic differentiation in MSCs.https://e-journal.unair.ac.id/JOINTS/article/view/49108bonehuman and medicinehypergravitymesenchymal stem cellosteoblastosteogenic differentiation |
| spellingShingle | Wisnu Sudrajad Andre Erica Indrawan Devangga Kusuma Bagus Wibowo Soetojo Heri Suroto Hypergravity as a Possible Way of Bone Tissue Engineering in Osteoblastic Differentiation from Mesenchymal Stem Cells: A Systematic Review Journal Orthopaedi and Traumatology Surabaya bone human and medicine hypergravity mesenchymal stem cell osteoblast osteogenic differentiation |
| title | Hypergravity as a Possible Way of Bone Tissue Engineering in Osteoblastic Differentiation from Mesenchymal Stem Cells: A Systematic Review |
| title_full | Hypergravity as a Possible Way of Bone Tissue Engineering in Osteoblastic Differentiation from Mesenchymal Stem Cells: A Systematic Review |
| title_fullStr | Hypergravity as a Possible Way of Bone Tissue Engineering in Osteoblastic Differentiation from Mesenchymal Stem Cells: A Systematic Review |
| title_full_unstemmed | Hypergravity as a Possible Way of Bone Tissue Engineering in Osteoblastic Differentiation from Mesenchymal Stem Cells: A Systematic Review |
| title_short | Hypergravity as a Possible Way of Bone Tissue Engineering in Osteoblastic Differentiation from Mesenchymal Stem Cells: A Systematic Review |
| title_sort | hypergravity as a possible way of bone tissue engineering in osteoblastic differentiation from mesenchymal stem cells a systematic review |
| topic | bone human and medicine hypergravity mesenchymal stem cell osteoblast osteogenic differentiation |
| url | https://e-journal.unair.ac.id/JOINTS/article/view/49108 |
| work_keys_str_mv | AT wisnusudrajad hypergravityasapossiblewayofbonetissueengineeringinosteoblasticdifferentiationfrommesenchymalstemcellsasystematicreview AT andreericaindrawan hypergravityasapossiblewayofbonetissueengineeringinosteoblasticdifferentiationfrommesenchymalstemcellsasystematicreview AT devanggakusuma hypergravityasapossiblewayofbonetissueengineeringinosteoblasticdifferentiationfrommesenchymalstemcellsasystematicreview AT baguswibowosoetojo hypergravityasapossiblewayofbonetissueengineeringinosteoblasticdifferentiationfrommesenchymalstemcellsasystematicreview AT herisuroto hypergravityasapossiblewayofbonetissueengineeringinosteoblasticdifferentiationfrommesenchymalstemcellsasystematicreview |