Ursolic Acid Inhibits Collagen Production and Promotes Collagen Degradation in Skin Dermal Fibroblasts: Potential Antifibrotic Effects

Ursolic Acid Inhibits Collagen Production and Promotes Collagen Degradation in Skin Dermal Fibroblasts: Potential Antifibrotic Effects

Tissue fibrosis, characterized by excessive collagen accumulation, leads to impaired organ function and is a hallmark of various chronic diseases. Fibroblasts play a central role in collagen production and deposition. This study examines the impact of ursolic acid, a pentacyclic triterpenoid compoun...

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Bibliographic Details
Main Authors: Tianyuan He, Yaping Xiang, Hehui Quan, Yingchun Liu, Chunfang Guo, Taihao Quan
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Biomolecules
Subjects:
ursolic acid
fibrosis
collagen
MMP-1
TGF-β/Smad
MAKP
Online Access:https://www.mdpi.com/2218-273X/15/3/365
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