Development and validation of an HPLC-DAD analytical method for quantitative and simultaneous determination of cefoperazone and prednisolone in intramammary ointment

Development and validation of an HPLC-DAD analytical method for quantitative and simultaneous determination of cefoperazone and prednisolone in intramammary ointment

Cefoperazone (CPZ) is a third-generation cephalosporin used to treat bovine mastitis. The association with steroidal anti-inflammatory drugs, such as prednisolone (PRED), provides an improvement in the animal's clinical response, which justifies its use. An analytical method capable of simultan...

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Bibliographic Details
Main Authors: Patrícia Espinosa dos Santos, Jefferson Annunciatto, Teófilo Fernando Mazon Cardoso, Marcos Serrou do Amaral, Nájla Mohamad Kassab
Format: Article
Language:English
Published: Universidade Federal do Rio Grande do Sul 2025-07-01
Series:Drug Analytical Research
Subjects:
cefoperazone
prednisolone
validation
hplc
quality control
Online Access:https://seer.ufrgs.br/index.php/dar/article/view/146375/96052
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