Tumor-Activated TCRγδ+ T Cells from Gastric Cancer Patients Induce the Antitumor Immune Response of TCRαβ+ T Cells via Their Antigen-Presenting Cell-Like Effects
Human γδ T cells display the principal characteristics of professional antigen-presenting cells (APCs), in addition to playing a vital role in immunity through cytokine secretion and their cytotoxic activity. However, it is not clear whether γδ T cells perform APC-like functions under pathological c...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/593562 |
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| author | Chaoming Mao Xiao Mou Yuepeng Zhou Guoyue Yuan Chengcheng Xu Hongli Liu Tingting Zheng Jia Tong Shengjun Wang Deyu Chen |
| author_facet | Chaoming Mao Xiao Mou Yuepeng Zhou Guoyue Yuan Chengcheng Xu Hongli Liu Tingting Zheng Jia Tong Shengjun Wang Deyu Chen |
| author_sort | Chaoming Mao |
| collection | DOAJ |
| description | Human γδ T cells display the principal characteristics of professional antigen-presenting cells (APCs), in addition to playing a vital role in immunity through cytokine secretion and their cytotoxic activity. However, it is not clear whether γδ T cells perform APC-like functions under pathological conditions. In this study, we showed that, in contrast to peripheral-derived γδ T cells directly isolated from PBMCs of gastric cancer patients, tumor-activated γδ T cells not only killed tumor cells efficiently but also strongly induced primary CD4+ and CD8+ αβ T cells proliferation and differentiation. More importantly, they abrogated the immunosuppression induced by CD4+CD25+ Treg cells and induced the cytotoxic function of CD8+ αβ T cells from patients with gastric cancer. In conclusion, tumor-activated γδ T cells can induce adaptive immune responses through their APC-like functions, and these cells may be a potentially useful tool in the development of tumor vaccines and immunotherapy. |
| format | Article |
| id | doaj-art-2d5039d064364a4db2a9b341d1fa498a |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-2d5039d064364a4db2a9b341d1fa498a2025-08-20T02:24:07ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/593562593562Tumor-Activated TCRγδ+ T Cells from Gastric Cancer Patients Induce the Antitumor Immune Response of TCRαβ+ T Cells via Their Antigen-Presenting Cell-Like EffectsChaoming Mao0Xiao Mou1Yuepeng Zhou2Guoyue Yuan3Chengcheng Xu4Hongli Liu5Tingting Zheng6Jia Tong7Shengjun Wang8Deyu Chen9Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang 212001, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang 212001, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang 212001, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang 212001, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang 212001, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang 212001, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang 212001, ChinaDepartment of Immunology and Laboratory Immunology, School of Medical Science and Laboratory Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, ChinaDepartment of Immunology and Laboratory Immunology, School of Medical Science and Laboratory Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, ChinaInstitute of Oncology, The Affiliated Hospital to Jiangsu University, 438 Jiefang Road, Zhenjiang 212001, ChinaHuman γδ T cells display the principal characteristics of professional antigen-presenting cells (APCs), in addition to playing a vital role in immunity through cytokine secretion and their cytotoxic activity. However, it is not clear whether γδ T cells perform APC-like functions under pathological conditions. In this study, we showed that, in contrast to peripheral-derived γδ T cells directly isolated from PBMCs of gastric cancer patients, tumor-activated γδ T cells not only killed tumor cells efficiently but also strongly induced primary CD4+ and CD8+ αβ T cells proliferation and differentiation. More importantly, they abrogated the immunosuppression induced by CD4+CD25+ Treg cells and induced the cytotoxic function of CD8+ αβ T cells from patients with gastric cancer. In conclusion, tumor-activated γδ T cells can induce adaptive immune responses through their APC-like functions, and these cells may be a potentially useful tool in the development of tumor vaccines and immunotherapy.http://dx.doi.org/10.1155/2014/593562 |
| spellingShingle | Chaoming Mao Xiao Mou Yuepeng Zhou Guoyue Yuan Chengcheng Xu Hongli Liu Tingting Zheng Jia Tong Shengjun Wang Deyu Chen Tumor-Activated TCRγδ+ T Cells from Gastric Cancer Patients Induce the Antitumor Immune Response of TCRαβ+ T Cells via Their Antigen-Presenting Cell-Like Effects Journal of Immunology Research |
| title | Tumor-Activated TCRγδ+ T Cells from Gastric Cancer Patients Induce the Antitumor Immune Response of TCRαβ+ T Cells via Their Antigen-Presenting Cell-Like Effects |
| title_full | Tumor-Activated TCRγδ+ T Cells from Gastric Cancer Patients Induce the Antitumor Immune Response of TCRαβ+ T Cells via Their Antigen-Presenting Cell-Like Effects |
| title_fullStr | Tumor-Activated TCRγδ+ T Cells from Gastric Cancer Patients Induce the Antitumor Immune Response of TCRαβ+ T Cells via Their Antigen-Presenting Cell-Like Effects |
| title_full_unstemmed | Tumor-Activated TCRγδ+ T Cells from Gastric Cancer Patients Induce the Antitumor Immune Response of TCRαβ+ T Cells via Their Antigen-Presenting Cell-Like Effects |
| title_short | Tumor-Activated TCRγδ+ T Cells from Gastric Cancer Patients Induce the Antitumor Immune Response of TCRαβ+ T Cells via Their Antigen-Presenting Cell-Like Effects |
| title_sort | tumor activated tcrγδ t cells from gastric cancer patients induce the antitumor immune response of tcrαβ t cells via their antigen presenting cell like effects |
| url | http://dx.doi.org/10.1155/2014/593562 |
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