Cancer-associated fibroblasts in ovarian cancer: research progress
Ovarian cancer, known for its high invasiveness and therapeutic resistance, is one of the leading causes of death from gynecological tumors. The tumor microenvironment (TME) plays a crucial role in the development of ovarian cancer, with cancer-associated fibroblasts (CAFs) being a key non-tumor cel...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1504762/full |
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| author | Yuance Xu Danting Sun Junqi He Qin Yao |
| author_facet | Yuance Xu Danting Sun Junqi He Qin Yao |
| author_sort | Yuance Xu |
| collection | DOAJ |
| description | Ovarian cancer, known for its high invasiveness and therapeutic resistance, is one of the leading causes of death from gynecological tumors. The tumor microenvironment (TME) plays a crucial role in the development of ovarian cancer, with cancer-associated fibroblasts (CAFs) being a key non-tumor cell component. They significantly affect the prognosis of ovarian cancer by promoting tumor cell proliferation, invasion, metastasis, immune evasion, and drug resistance. The heterogeneity of CAFs provides a new perspective for targeted therapy in ovarian cancer. This review comprehensively analyzes the mechanisms of action, heterogeneity characteristics, and role in the immune microenvironment of CAFs in ovarian cancer, and discusses targeted therapy strategies for CAFs, aiming to provide new theoretical basis and treatment directions for the treatment of ovarian cancer. |
| format | Article |
| id | doaj-art-2d4dbd41b3d94f288919106b8956502d |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-2d4dbd41b3d94f288919106b8956502d2025-08-20T02:46:25ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-03-011510.3389/fonc.2025.15047621504762Cancer-associated fibroblasts in ovarian cancer: research progressYuance XuDanting SunJunqi HeQin YaoOvarian cancer, known for its high invasiveness and therapeutic resistance, is one of the leading causes of death from gynecological tumors. The tumor microenvironment (TME) plays a crucial role in the development of ovarian cancer, with cancer-associated fibroblasts (CAFs) being a key non-tumor cell component. They significantly affect the prognosis of ovarian cancer by promoting tumor cell proliferation, invasion, metastasis, immune evasion, and drug resistance. The heterogeneity of CAFs provides a new perspective for targeted therapy in ovarian cancer. This review comprehensively analyzes the mechanisms of action, heterogeneity characteristics, and role in the immune microenvironment of CAFs in ovarian cancer, and discusses targeted therapy strategies for CAFs, aiming to provide new theoretical basis and treatment directions for the treatment of ovarian cancer.https://www.frontiersin.org/articles/10.3389/fonc.2025.1504762/fullovarian cancercancer-associated fibroblasts (CAFs)tumor microenvironmenttargeted therapyimmune microenvironment |
| spellingShingle | Yuance Xu Danting Sun Junqi He Qin Yao Cancer-associated fibroblasts in ovarian cancer: research progress Frontiers in Oncology ovarian cancer cancer-associated fibroblasts (CAFs) tumor microenvironment targeted therapy immune microenvironment |
| title | Cancer-associated fibroblasts in ovarian cancer: research progress |
| title_full | Cancer-associated fibroblasts in ovarian cancer: research progress |
| title_fullStr | Cancer-associated fibroblasts in ovarian cancer: research progress |
| title_full_unstemmed | Cancer-associated fibroblasts in ovarian cancer: research progress |
| title_short | Cancer-associated fibroblasts in ovarian cancer: research progress |
| title_sort | cancer associated fibroblasts in ovarian cancer research progress |
| topic | ovarian cancer cancer-associated fibroblasts (CAFs) tumor microenvironment targeted therapy immune microenvironment |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1504762/full |
| work_keys_str_mv | AT yuancexu cancerassociatedfibroblastsinovariancancerresearchprogress AT dantingsun cancerassociatedfibroblastsinovariancancerresearchprogress AT junqihe cancerassociatedfibroblastsinovariancancerresearchprogress AT qinyao cancerassociatedfibroblastsinovariancancerresearchprogress |